Atorvastatin attenuates the antinociceptive tolerance of morphine via nitric oxide dependent pathway in male mice

Hassanipour, Mahsa; Amini-Khoei, Hossein; Shafaroodi, Hamed; Shirzadian, Armin; Rahimi, Nastaran; Khan, Muhammad Imran; Rezayat, Seyed Mehdi; Dehpour, Ahmad Reza

doi:10.1016/j.brainresbull.2016.07.002

Cited by 31 publications

(21 citation statements)

References 59 publications

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“…Recent studies on the possible mechanisms of morphine analgesic tolerance indicated that increased production of nitric oxide and free radicals played important roles 16, 17, 18. In this study, GTPm markedly suppressed naloxone-induced hyperactivities (Fig.…”

Section: Discussionsupporting

confidence: 61%

“…We proposed that combination of GTP with memantine (GTPm) might have analgesic effect on orofacial pain. In this study, we also investigated the analgesic effect of memantine used alone and GTPm with or without morphine, which is commonly used for treatment of orofacial pain, but morphine induced unbearable side effects (depression, constipation, respiratory inhibition) and morphine tolerance 16, 17, 18. Thus, we tried in this study to test whether GTPm was capable of attenuating morphine tolerance which could be precipitated by the μ-opioid receptor antagonist naloxone 19 .…”

Section: Introductionmentioning

confidence: 99%

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Studies on a novel regimen for management of orofacial pain and morphine tolerance

Lee

Huang

Chou

et al. 2018

Journal of Dental Sciences

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Background/purpose The prevalence of orofacial pain is high but the etiology of orofacial pain is not well understood. Because of clinical treatment is not so effective, it is urgent to explore novel regimens with more effective and less side effects for clinical application. Materials and methods Male mice (ICR strain) were injected with capsaicin (10μg/5 μl) in vibrissa pad. Spontaneous orofacial pain in 20 min was recorded after receiving capsaicin to quantify the nociceptive level. Green tea polyphenols (GTP 60 mg/kg), memantine (Mem 10 mg/kg), and GTPm (GTP 30 mg/kg plus Mem 3 mg/kg) were dissolved in 2% carboxymethyl cellulose, which was orally administered to mice twice per day and five times per week consecutively for 2 weeks. TruScan photobeam tracking was used to record changes of behavior and locomotor activities. Results GTPm by itself attenuated orofacial pain induced by capsaicin. Moreover, GTPm enhanced morphine analgesic effects, reduced morphine depressant side effects and delayed morphine tolerance. Along with this experiment, GTPm was tested on the hot plate (52 °C)-induced peripheral thermal pain. It was found that both memantine and GTPm reduced morphine-analgesia in hind paw thermal pain. Conclusion In this study, GTP (60 mg/kg/day) orally administrated produced a significant analgesic effect on capsaicin–induced orofacial pain. Memantine combined with GTP synergistically not only reduced orofacial pain but also enhanced morphine analgesic effects. Thus, a new regimen of GTPm orally administered twice per day attenuated orofacial pain after consecutive 5 days.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Studies on a novel regimen for management of orofacial pain and morphine tolerance

Lee

Huang

Chou

et al. 2018

Journal of Dental Sciences

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“…Morphine suppresses many types of pain, but tolerance, physical dependence, and unwanted side effects limit its clinical use (Trang et al, 2007). Identification of therapeutic strategies for blocking opioid tolerance and dependence has therefore evolved as an area of intense research interest (Habibi-Asl et al, 2014;Mansouri, et al, 2015;Hassanipour et al, 2016;Hosseinzadeh et al, 2016). Adjunctive pharmacotherapies that combine mechanistically distinct analgesics represent one such approach.…”

Section: Introductionmentioning

confidence: 99%

Slowly Signaling G Protein–Biased CB₂Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence

et al. 2017

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The CB cannabinoid agonist LY2828360 lacked both toxicity and efficacy in a clinical trial for osteoarthritis. Whether LY2828360 suppresses neuropathic pain has not been reported, and its signaling profile is unknown. In vitro, LY2828360 was a slowly acting but efficacious G protein-biased CB agonist, inhibiting cAMP accumulation and activating extracellular signal-regulated kinase 1/2 signaling while failing to recruit arrestin, activate inositol phosphate signaling, or internalize CB2 receptors. In wild-type (WT) mice, LY2828360 (3 mg/kg per day i.p. × 12 days) suppressed chemotherapy-induced neuropathic pain produced by paclitaxel without producing tolerance. Antiallodynic efficacy of LY2828360 was absent in CB knockout (KO) mice. Morphine (10 mg/kg per day i.p. × 12 days) tolerance developed in CBKO mice but not in WT mice with a history of LY2828360 treatment (3 mg/kg per day i.p. × 12 days). LY2828360-induced antiallodynic efficacy was preserved in WT mice previously rendered tolerant to morphine (10 mg/kg per day i.p. × 12 days), but it was absent in morphine-tolerant CBKO mice. Coadministration of LY2828360 (0.1 mg/kg per day i.p. × 12 days) with morphine (10 mg/kg per day × 12 days) blocked morphine tolerance in WT but not in CBKO mice. WT mice that received LY2828360 coadministered with morphine exhibited a trend ( = 0.055) toward fewer naloxone-precipitated jumps compared with CBKO mice. In conclusion, LY2828360 is a slowly signaling, G protein-biased CB agonist that attenuates chemotherapy-induced neuropathic pain without producing tolerance and may prolong effective opioid analgesia while reducing opioid dependence. LY2828360 may be useful as a first-line treatment in chemotherapy-induced neuropathic pain and may be highly efficacious in neuropathic pain states that are refractive to opioid analgesics.

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“…2,3 Previous studies have shown some different cellular and molecular mechanisms involved in morphine tolerance. For example role of GABAergic system and GABA transporters, [4][5][6][7] Involvement of nitric oxide synthase (NOS) 8 and effect of glutaminergic system on the tolerance.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies represent the inhibitory effect of nitric oxide synthase in reducing morphine tolerance, confirming our results. 8 On the other hand, inhibitory effect of Scrophularia genus on nitric oxide synthase was shown. 13 Scrophularia genus can reduce endogenous nitric oxide resulting in reducing tolerance to analgesic effects of morphine.…”

mentioning

confidence: 99%

Evaluation of the Effect of Aerial Parts of Scrophularia atropatana Grossh Total Extracts on Analgesic Activity and Morphine Induced Tolerance in Mice

Habibiasl¹,

Majidi²,

Fekri³

et al. 2018

Pharm Sci

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Atorvastatin attenuates the antinociceptive tolerance of morphine via nitric oxide dependent pathway in male mice

Cited by 31 publications

References 59 publications

Studies on a novel regimen for management of orofacial pain and morphine tolerance

Studies on a novel regimen for management of orofacial pain and morphine tolerance

Slowly Signaling G Protein–Biased CB₂Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence

Evaluation of the Effect of Aerial Parts of Scrophularia atropatana Grossh Total Extracts on Analgesic Activity and Morphine Induced Tolerance in Mice

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Atorvastatin attenuates the antinociceptive tolerance of morphine via nitric oxide dependent pathway in male mice

Cited by 31 publications

References 59 publications

Studies on a novel regimen for management of orofacial pain and morphine tolerance

Studies on a novel regimen for management of orofacial pain and morphine tolerance

Slowly Signaling G Protein–Biased CB2Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence

Evaluation of the Effect of Aerial Parts of Scrophularia atropatana Grossh Total Extracts on Analgesic Activity and Morphine Induced Tolerance in Mice

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Slowly Signaling G Protein–Biased CB₂Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence