Evaluation of the Effect of Aerial Parts of Scrophularia atropatana Grossh Total Extracts on Analgesic Activity and Morphine Induced Tolerance in Mice

Habibiasl, B; Majidi, Zahra; Fekri, Kiarash; Delazar, Abbas; Vaez, Haleh

doi:10.15171/ps.2018.17

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…In recent years, lots of studies have been focused on the concept of pain (Luo et al, 2020;Parvizpur et al, 2020;Majidi et al, 2018). In this study, a natural compound which is extracted from an herb was evaluated.…”

Section: Discussionmentioning

confidence: 99%

Silymarin reduced cisplatin-induced hyperalgesia bysuppressing oxidative stress in male rats

et al. 2021

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Introduction: Cisplatin is an antineoplastic agent which is used in treatment of various cancers. However its clinical use is associated with oxidative stress-mediated neuropathic pain. This research aimed to explore the effect of silymarin on cisplatin-induced hyperalgesia (CIH) and oxidative stress biomarkers in male rats. Methods: Fifty-six male rats were allocated into seven equal groups. Hyperalgesia was caused by intraperitoneal single dose administration of cisplatin (1mg/kg) and assessed by utilizing tail-flick method. The impact of silymarin (25, 50 and 100 mg/kg/day for 15 days) on CIH was investigated on days 1, 5, 10 and 15. Blood samples were collected to assess malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant status (TAS) on day fifteen. Results: Single dose injection of cisplatin (1mg/kg) could cause a significant hyperalgesia on days 5, 10 and 15. CIH was abolished by daily administration of silymarin (50 and 100mg/kg) on days 10 and 15. Serum MDA level was decreased in cisplatin and silymarin (100 mg/kg) co-treated rats, while there was an increase in GPx, SOD as well as TAS parameters. Conclusion: The results of this study revealed that silymarin prevents from CIH possibly by improving lipid peroxidation and oxidative stress biomarkers. Other clinical studies should be performed to establish possible use of silymarin for treatment of CIH in susceptible individuals.

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Section: Discussionmentioning

confidence: 99%

Silymarin reduced cisplatin-induced hyperalgesia bysuppressing oxidative stress in male rats

et al. 2021

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Time to Take a Closer Look at the Controversial Effects of Antioxidants: Important Points to Be Remembered

Fekri,

Alizadeh Soufilar,

Alizadeh

2023

Biomed Res Bull

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The beneficial effects of antioxidants have been investigated and reported for decades. These include (but are not limited to) the positive effects on the endocrine, reproductive, and central nervous systems. Free radicals, which have been known to be formed during many processes, including drug metabolism, and introduced as the main player in oxidative stress conditions, would be scavenged and neutralized by antioxidant agents. Whether endogenous or exogenous, they have been known to stand against many pathologies such as neurodegeneration, nephrotoxicity, inflammation, cancer, and aging, as well as pain and related challenges, namely, tolerance and dependence on analgesics. Despite the numerous reports of the benefits, the volume of studies focusing on the potential harms seems to be insufficient. It is important to note that some of the negative effects can be serious and challenging. In fact, the words "negative" or "positive" would be defined under a particular condition. Most likely, the most well-known example would be the challenges of antioxidant consumption in carcinogenesis, although many other conditions would be the focus. In this regard, the overuse of many antioxidant nutraceuticals, such as vitamin E, β-carotene, and lipoic acid, has been reported to be associated with serious complications. In this review, in addition to the bright side, we are going to scrutinize the controversies surrounding antioxidant administration.

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Effects of Sodium Selenite and Vitamin E on the Development of Morphine Dependency in Mice

et al. 2020

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Background: Antioxidant drugs may be useful in preventing morphine-induced dependency bysuppressing oxidative stress. Vitamin E which has many essential roles in the body is a powerfulantioxidant. On the other hand, selenium is an essential trace element that plays a strong rolein various biochemical pathways. The aim of this study was to investigate the effects of sodiumselenite and vitamin E on morphine-induced dependency in mice. Methods: Ninety male mice, weighing 20 to 30 g, were randomly divided into 10 groups and weretreated as follows: a) saline and b) morphine groups were pretreated (for 2 days) with normalsaline (10 ml.kg-1.day-1, ip) then daily doses of normal saline (10 ml.kg-1.day-1, ip) and morphine(50 mg.kg-1.day-1) were added to the injections for the following 4 days, respectively. c, d, e)sodium selenite, f, g, h) vitamin E, i) vitamin E solvent (almond oil) and j) co-administrationgroups were pretreated (for 2 days) with sodium selenite (0.25, 0.5, 1 mg.kg-1.day-1, ip), vitaminE (20, 40, 60 IU.kg-1.day-1, ip), vitamin E solvent (10 ml.kg-1.day-1, ip) and combination of thedrugs respectively, then morphine doses (50 mg.kg-1.day-1, ip) were added to the injections forthe following 4 days. Withdrawal symptoms were evaluated after injecting naloxone (4 mg/kg/day). Biochemical evaluations were also performed. Results: The results showed that co-administration of sodium selenite and vitamin E (at lowdoses) significantly reduced morphine dependency (p < 0.05). Conclusion: The synergistic effect of sodium selenite and vitamin E can be a suitable andefficient approach to reduce dependency.

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Evaluation of the Effect of Aerial Parts of Scrophularia atropatana Grossh Total Extracts on Analgesic Activity and Morphine Induced Tolerance in Mice

Cited by 4 publications

References 28 publications

Silymarin reduced cisplatin-induced hyperalgesia bysuppressing oxidative stress in male rats

Silymarin reduced cisplatin-induced hyperalgesia bysuppressing oxidative stress in male rats

Time to Take a Closer Look at the Controversial Effects of Antioxidants: Important Points to Be Remembered

Effects of Sodium Selenite and Vitamin E on the Development of Morphine Dependency in Mice

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