Atorvastatin attenuates post-implant tissue degeneration of cardiac prosthetic valve bovine pericardial tissue in a subcutaneous animal model

Lorusso, Roberto; Corradi, Domenico; Maestri, Roberta; Bosio, Silvia; Curulli, Alessandra; Beghi, Cesare; Gerometta, Piersilvio; Russo, Claudio; Gelsomino, Sandro; Moreo, Antonella; Cicco, Giuseppe De; Rosano, Giuseppe; Volterrani, Maurizio

doi:10.1016/j.ijcard.2008.11.174

Cited by 15 publications

(16 citation statements)

References 34 publications

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“…Moreover, our results indicated that statin treatment could prevent post-implant calcification and inflammatory infiltration even in animals under hypercholesterolemic conditions. However, calcification degree was not significantly different between Groups 1 and 2 in our study, as opposed to Lorusso et al14)'s report. The major predictive factors for this discrepancy could be the differences in animal species and follow-up periods between the studies.…”

Section: Discussioncontrasting

confidence: 99%

“…Recently, an experimental study using bovine pericardial bioprosthesis in a rat subdermal implantation model showed that atorvastatin treatment attenuated bioprosthesis calcification along with reducing the global extent of inflammatory infiltrates 14). They concluded that these effects could enhance structural preservation of bioprostheses and diminish calcific deposition.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Rosuvastatin on Bovine Pericardial Aortic Tissue Valve Calcification in a Rat Subdermal Implantation Model

et al. 2017

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Background and ObjectivesThere are pathophysiologic similarities between calcification and atherosclerosis because both are the product of an active inflammatory process. The aim of this study was to examine the effects of statin treatment on calcification in bovine pericardial tissue valves.Materials and MethodsForty Sprague-Dawley rats were randomly divided into 4 groups according to hypercholesterolemia induction and statin intake (Group 1, n=10: normal diet without statin treatment, Group 2, n=10: normal diet with statin treatment, Group 3, n=10: high fat diet without statin treatment, Group 4, n=10: high fat diet with statin treatment). Serum lipid levels were measured just before the experiment and after 4 and 12 weeks. Bovine pericardial tissue valve cusps were surgically implanted in rat dorsal subcutis at 4 weeks. After the surgery, statin was administered daily to Groups 2 and 4. Serum interleukin-6 (IL-6) level was measured at 5 weeks. Cusps were explanted at 12 weeks and calcium levels were determined by atomic absorption spectroscopy.ResultsMean IL-6 was significantly higher in Group 3 at 5 weeks (7.14, 2.03, 31.70, and 6.90 pg/dL for each group, respectively). Mean calcium level in Group 3 was significantly higher among groups but Group 4 was significantly lower compared to Group 3 and was similar to Group 1, 2 (1.86, 1.92, 2.55, and 1.80 mg/g for each group, respectively, p<0.01).ConclusionHypercholesterolemia may be a significant risk factor for bovine pericardial valve calcification. Statin treatment significantly attenuated calcification of bovine pericardial valve tissue in a rat subdermal implantation model and might prolong the durability of bioprostheses.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Rosuvastatin on Bovine Pericardial Aortic Tissue Valve Calcification in a Rat Subdermal Implantation Model

et al. 2017

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“…Interestingly, Antonini-Canterin has shown that patients submitted to aortic valve replacement with a bioprosthetic valve and on statin therapy had a significantly reduced incidence of SVD with a mean follow-up of almost 4 years [21]. Our group has recently demonstrated, in an animal model, that statin therapy significantly reduces post-implant bioprosthetic tissue degeneration, and, notably, that this pharmacological treatment induces a more homogeneous postoperative histological change as compared to the highly variable reaction in the control group, thereby indicating that statins might mitigate the body's immunological and inflammatory reaction to heterologous biological tissue [22]. Several investigations are ongoing to better understand processes involved in native or biological valve calcification and test treatments to prevent or limit calcium-related degeneration.…”

Section: Structural Valve Deteriorationmentioning

confidence: 77%

“…The ISTHMUS Investigators / European Journal of Cardio-thoracic Surgery 39 (2011)[18][19][20][21][22][23][24][25][26] …”

mentioning

confidence: 99%

The Italian study on the Mitroflow postoperative results (ISTHMUS): a 20-year, multicentre evaluation of Mitroflow pericardial bioprosthesis☆

Investigators¹

2011

European Journal of Cardio-Thoracic Surgery

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“…Rajamannan et al published a recent study proving that bioprosthetic valve deterioration is an active atherosclerosis-like process 32 . Lorusso et al found that atorvastatin significantly attenuated the post-implant structural degeneration of artificial valve bovine pericardial tissue in a subcutaneous animal model 33 . The difference in lifespan of bioprosthetic valves compared with their native counterparts might be explained by the different underlying pathophysiological process.…”

Section: Pathogenesis Of Bioprosthetic Heart Valve Dysfunctionmentioning

confidence: 99%

The role of statin treatment in valvular heart disease: is the jury still out?

et al. 2013

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Valvular heart disease (VHD) represents a signifi cant burden within the spectrum of cardiovascular diseases. In recent years, there has been a great interest in fi nding medical treatments able to slow the progression of VHD. The negative results of several large randomized trials failing to demonstrate a benefi t of such therapies, has led to a decrease of interest in this fi eld. However, fi nding a medical treatment capable of preventing VHD progression is still a hot topic, due to the important clinical implications. We believe that the jury is still out on the debate about the role of statin therapy in VHD, considering also recently published studies providing new information with future implications for the treatment of this disease process. This article gives an overview of the published evidence about the role of hydroxymethylglutaryl coenzyme-A reductase inhibitors on delaying progressive valve dysfunction. A preventive therapy, which could infl uence not only the haemodynamic progression of valve disease, but also the cardiovascular outcome, is warranted. Large, prospective, randomized trials are needed to properly evaluate the role of statins in the early stages of valvular heart disease.

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Atorvastatin attenuates post-implant tissue degeneration of cardiac prosthetic valve bovine pericardial tissue in a subcutaneous animal model

Cited by 15 publications

References 34 publications

Effect of Rosuvastatin on Bovine Pericardial Aortic Tissue Valve Calcification in a Rat Subdermal Implantation Model

Effect of Rosuvastatin on Bovine Pericardial Aortic Tissue Valve Calcification in a Rat Subdermal Implantation Model

The Italian study on the Mitroflow postoperative results (ISTHMUS): a 20-year, multicentre evaluation of Mitroflow pericardial bioprosthesis☆

The role of statin treatment in valvular heart disease: is the jury still out?

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