Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study

Begemann, Marieke J H; Linszen, Mascha M J; Boer, J N de; Hovenga, Wytske D.; Gangadin, Shiral S.; Schutte, Maya; Sommer, Iris

doi:10.3389/fpsyt.2019.00453

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…As outlined above, another reason could be the open phrasing of the QPE screening questions. This possibility aligns with the similar high prevalence of endorsement in studies using the full QPE interview (Begemann et al ., 2019; de Boer et al ., 2019).…”

Section: Discussionmentioning

confidence: 99%

“…However, although the QPE screening questionnaire has already been used as a self-report questionnaire (Begemann, Linszen, de Boer et al, 2019) to group participants in terms of presence/frequency of PLEs (de Boer, Linszen, de Vries et al, 2019), only the full QPE interview has been validated in a patient population so far (Rossell et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…For this reason, Sommer and colleagues (2018) provided a short QPE screening questionnaire that only asks about the presence of hallucinatory and delusional experiences. However, although the QPE screening questionnaire has already been used as a self‐report questionnaire (Begemann, Linszen, de Boer et al ., 2019) to group participants in terms of presence/frequency of PLEs (de Boer, Linszen, de Vries et a l ., 2019), only the full QPE interview has been validated in a patient population so far (Rossell et al ., 2019).…”

Section: Introductionmentioning

confidence: 99%

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Mapping psychotic‐like experiences: Results from an online survey

Kusztrits

Larøi

Laloyaux

et al. 2020

Scandinavian J Psychology

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Suggestions have been made that psychotic-like experiences (PLEs), such as hallucinatory and delusional experiences, exist on a continuum from healthy individuals to patients with a diagnosis of schizophrenia. We used the screening questions of the Questionnaire for Psychotic Experiences (QPE), an interview that captures the presence and phenomenology of various psychotic experiences separately, to assess PLEs in Norway. Based on data from an online survey in a sample of more than 1,400 participants, we demonstrated that the QPE screening questions show satisfactory psychometric properties. Participants with mental disorders reported more frequent lifetime and current hallucinatory experiences than participants without mental disorders. Childhood experiences were rather low and ranged from 0.7% to 5.2%. We further replicated findings that young age, illegal drug use, lower level of education, and having parents with a mental disorder are associated with higher endorsement rates of PLEs. Finally, a binomial regression revealed that the mere presence of PLEs does not discriminate between individuals with and without a mental disorder. Taken together, the findings of the present study support existing models that both hallucinations and delusions exist on a structural and phenomenological continuum. Moreover, we demonstrated that the QPE screening questions can be used by themselves as a complementary tool to the full QPE interview.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mapping psychotic‐like experiences: Results from an online survey

Kusztrits

Larøi

Laloyaux

et al. 2020

Scandinavian J Psychology

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“…A description of the survey is provided elsewhere 28,29 . For the current study, we used two questionnaires; the Questionnaire for Psychotic Experiences (QPE) and the Pittsburgh Sleep Quality Index (PSQI).…”

Section: Surveymentioning

confidence: 99%

Fragmented sleep relates to hallucinations across perceptual modalities in the general population

Brederoo

Boer

Vries

et al. 2021

Sci Rep

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Although previous studies reported a link between sleep problems and the occurrence of hallucinations, more detailed information is needed to translate this association into clinical practice. This study investigates sleep quality and its relation to prevalence, type, content, and phenomenology of hallucinations, using an online survey in a large population sample (n = 10,299). Based on community-based cluster analysis, four groups could be distinguished that differed in terms of sleep quality. Our results confirm previous studies in showing that poor sleep is associated with the occurrence of hallucinations, and extend previous results on a number of aspects. First, we show that particularly fragmented sleep relates to the occurrence of hallucinations. Second, we show that this is the case for hallucinations across the auditory, visual, olfactory, and tactile domains. Third, our results show that fragmented sleep not only relates to the occurrence, but also to the content, frequency, duration, and associated distress of hallucinations. Finally, compared to poor sleep, good sleep quality is associated with hallucinations that are less negative and disruptive. We conclude that sleep hygiene measures could have a large positive impact on individuals whose fragmented sleep underlies the occurrence of bothersome hallucinations.

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“…Potential mechanisms for the relationships are unclear; however, proposed hypotheses include shared genetic susceptibility, immune dysregulation, unhealthy lifestyle choices (eg, harmful alcohol use), and chronic itch in AE leading to sleep deprivation and subsequent psychiatric symptoms. 13 , 14 , 18–22 …”

Section: Introductionmentioning

confidence: 99%

Severe Mental Illness Among Adults with Atopic Eczema or Psoriasis: Population-Based Matched Cohort Studies within UK Primary Care

Adesanya¹,

Henderson²,

Matthewman³

et al. 2023

CLEP

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Background Existing research exploring associations between atopic eczema (AE) or psoriasis, and severe mental illness (SMI – ie, schizophrenia, bipolar disorder, other psychoses) is limited, with longitudinal evidence particularly scarce. Therefore, temporal directions of associations are unclear. We aimed to investigate associations between AE or psoriasis and incident SMI among adults. Methods We conducted matched cohort studies using primary care electronic health records (January 1997 to January 2020) from the UK Clinical Practice Research Datalink GOLD. We identified two cohorts: 1) adults (≥18 years) with and without AE and 2) adults with and without psoriasis. We matched (on age, sex, general practice) adults with AE or psoriasis with up to five adults without. We used Cox regression, stratified by matched set, to estimate hazard ratios (HRs) comparing incident SMI among adults with and without AE or psoriasis. Results We identified 1,023,232 adults with AE and 4,908,059 without, and 363,210 with psoriasis and 1,801,875 without. After adjusting for matching variables (age, sex, general practice) and potential confounders (deprivation, calendar period) both AE and psoriasis were associated with at least a 17% increased hazard of SMI (AE: HR=1.17,95% CI=1.12–1.22; psoriasis: HR=1.26,95% CI=1.18–1.35). After additionally adjusting for potential mediators (comorbidity burden, harmful alcohol use, smoking status, body mass index, and, in AE only, sleep problems and high-dose glucocorticoids), associations with SMI did not persist for AE (HR=0.98,95% CI=0.93–1.04), and were attenuated for psoriasis (HR=1.14,95% CI=1.05–1.23). Conclusion Our findings suggest adults with AE or psoriasis are at increased risk of SMI compared to matched comparators. After adjusting for potential mediators, associations with SMI did not persist for AE, and were attenuated for psoriasis, suggesting that the increased risk may be explained by mediating factors (eg, sleep problems). Our research highlights the importance of monitoring mental health in adults with AE or psoriasis.

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Atopy Increases Risk of Psychotic Experiences: A Large Population-Based Study

Cited by 10 publications

References 26 publications

Mapping psychotic‐like experiences: Results from an online survey

Mapping psychotic‐like experiences: Results from an online survey

Fragmented sleep relates to hallucinations across perceptual modalities in the general population

Severe Mental Illness Among Adults with Atopic Eczema or Psoriasis: Population-Based Matched Cohort Studies within UK Primary Care

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