Atopy and Risk of Non-Hodgkin Lymphoma

Melbye, Mads; Smedby, Karin E.; Lehtinen, Tuula; Rostgaard, Klaus; Glimelius, Bengt; Munksgaard, Lars; Schöllkopf, Claudia; Sundström, Christer; Chang, Ellen T.; Koskela, Pentti; Adami, Hans‐Olov; Hjalgrim, Henrik

doi:10.1093/jnci/djk019

Cited by 62 publications

(95 citation statements)

References 26 publications

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“…Our results are consistent with several previous studies that showed an inverse association between atopy and lymphoma (9,10). In particular, a recent case-control study conducted in Finland (9) reported an inverse risk association between overall NHL and positive specific IgE (OR, 0.68; 95% CI, 0.58-0.80) with risk associations for some (CLL, follicular, and lymphoplasmacytic) but not all (diffuse, marginal zone, and T cell) individual NHL subtypes being similar to those reported in the current study.…”

Section: Discussionsupporting

confidence: 94%

“…However, the percentage concordance between selfreported asthma and total IgE levels (data not shown) were not markedly different between cases and controls (16% versus 10%, respectively), suggesting that lymphoma-induced IgE suppression was not a likely explanation for the case/control differences in IgE observed in the current analyses. One other study (9) has reported a stronger inverse association between NHL and positive specific IgE with more advanced stage of disease. The same study also showed no difference in IgE levels in cases and controls using serum collected during pregnancy years before an NHL diagnosis.…”

Section: Discussionmentioning

confidence: 90%

“…Melbye et al (9) reported a significant inverse association with B-cell lymphoma and specific IgE reactivity with the strongest association seen with more advanced stage of disease. McCormick et al (10) reported patients (n = 45) with CLL to have lower IgE levels than other patients with HL (n = 98), reticulum cell sarcoma (n = 33), and lymphosarcoma (n = 53).…”

Section: Introductionmentioning

confidence: 99%

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Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Ellison‐Loschmann

Benavente

Douwes

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Epidemiologic studies have shown an inverse association between atopy and malignant lymphoma, but results are inconsistent. We investigated levels of IgE, before and after commencement of treatment, and evaluated lymphoma risk in relation to total and specific IgE levels. Serum levels of IgM, IgA, and IgG were also measured. We enrolled 467 newly diagnosed lymphoma cases and 544 hospital controls, matched for age, sex, and hospital. Lymphomas were histologically confirmed and categorized according to the WHO classification. Subjects provided blood for analysis of total and specific IgE levels, and total IgM, IgA, and IgG levels. Additional information was collected by intervieweradministered questionnaire. Controlling for age, sex, center, smoking status, and any treated asthma or eczema, we found that the overall risk of lymphoma was significantly lower in the high [odds ratio (OR), 0.39; 95% confidence interval (95% CI), 0.28-0.54] and middle (OR, 0.55; 95% CI, 0.40-0.74) tertiles for total serum IgE compared with the low tertile. Specific IgE to common aeroallergens (defined as z0.35 kU/L) was also inversely associated with risk of lymphoma (OR, 0.67; 95% CI, 0.45-1.00). Lymphoma was associated with IgA and IgM but not IgG. Mean levels of all immunoglobulins were decreased with more advanced malignancy, and total serum IgE levels were lower before treatment. The data suggest that the low levels of immunoglobulins seen in a wide range of lymphoma cases is likely to be linked to a lymphogenesis process rather than resulting from a selective protection due to an atopic process. Long-term cohort studies may be fundamental to fully evaluate these associations. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1492 -8)

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Ellison‐Loschmann

Benavente

Douwes

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…35,36 In NHL patients intrinsic B-cell defects, increased T-cell or monocyte suppressor activity, and diminished T-helper activity m a y a l s o c o n t r i b u t e t o t h e hypogammaglobulinaemia. [37][38][39] One of ten studied patients with NHL had an M band, this has been reported by other worker. 40 Patients with HL have a well-described cellular immune deficiency, which is based on clinical and laboratory findings.…”

Section: Frequency Of M Bands Showed By Serum Protein Electrophoresismentioning

confidence: 67%

Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq

Maulood¹,

Alnaqshabandi

2017

Zanco J Med Sci

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“…Aunque experimentalmente un animal en buenas condiciones higiénicas puede sobrevivir sin este anticuerpo (20), en los estudios epidemiológicos de ambientes con altos índices de infestación parasitaria, la IgE se asocia a resistencia a ciertos helmintos (22). También, participa en la respuesta inmunitaria contra tumores (23); hay evidencia de asociación inversa entre varios tipos de cáncer y atopia (24,25) y producción de IgE específica contra antígenos tumorales (26). Su impacto en este aspecto comienza a estudiarse con mayor profundidad y el papel en la evolución de la respuesta de tipo 2 no se ha analizado.…”

Section: Inmunoglobulina Eunclassified