Atopic profile of inner-city asthma with a comparative analysis on the cockroach-sensitive and ragweed-sensitive subgroups

Kang, Bann C.; Johnson, J.; Veres-Thorner, Chris

doi:10.1016/0091-6749(93)90057-m

Cited by 88 publications

(56 citation statements)

References 27 publications

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“…35-5.66 Exposure to indoor allergens has recently been suggested as a source of respiratory morbidity. Between 70 and 90% of children and young adults with asthma have one or more positive skin tests to aeroallergen (22,29); the frequency is similar in asthmatic patients in urban dinics (30)(31)(32)(33). The pattern of specific allergen sensitivity differs from that in the general population, with a higher frequency of sensitivity to cockroach and molds and less frequent sensitivity to cats, dogs, and house dust mites.…”

Section: Introductionmentioning

confidence: 83%

The Environment and Asthma in US Inner Cities

Eggleston

2007

Chest

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Section: Introductionmentioning

confidence: 83%

The Environment and Asthma in US Inner Cities

Eggleston

2007

Chest

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“…Although many factors have been associated with this phenomenon, there is growing evidence that exposure to allergens and irritants in the home is particularly important (2). Cat, cockroach, and house dust mite exposures have been associated with asthma exacerbations in sensitized individuals with asthma (3)(4)(5)(6), and studies suggest that children exposed to smoking in the household have greater disease severity than those not exposed (7)(8)(9). Recently, levels of mouse allergen in the home have been related to skin test sensitivity and asthma morbidity (10); in the National Cooperative Inner-City Asthma Study (NCICAS), 19% of children with moderate to severe asthma were sensitized to rat allergen and 15% to mouse (11).…”

mentioning

confidence: 99%

Home and allergic characteristics of children with asthma in seven U.S. urban communities and design of an environmental intervention: the Inner-City Asthma Study.

Crain

Walter

O’Connor

et al. 2002

Environ Health Perspect

165

124

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Most published environmental remediation interventions have been directed at single allergens and have employed demanding strategies; few have been performed in the homes of inner-city children disproportionately burdened by asthma. Our objective was a) to describe the allergen sensitivities, environmental tobacco smoke (ETS) exposure, and home environmental characteristics of a national sample of inner-city children with moderate to severe asthma and b) to develop and implement a multifaceted, home-based comprehensive intervention to reduce home allergens and ETS, tailored to the specific sensitization and exposure profiles of those children. Allergen skin testing and a home evaluation were performed to determine the presence of ETS and factors known to be associated with increased indoor allergen levels. Based on published remediation techniques, a home environmental intervention, organized into modules, each addressing one of five specific allergen groups or ETS, was designed. Of 994 allergic children from seven U.S. urban communities, 937 successfully completed baseline interviews and home allergen surveys and were enrolled. More than 50% of children had positive skin tests to three or more allergen groups. Cockroaches were reported in 58% of homes, wall-to-wall carpeting in the child's bedroom in 55%, a smoker in 48%, mice or rats in 40%, and furry pets in 28%. More than 60% of enrolled families received four or more modules, and between 94% and 98% of all modules were completed. We conclude that most inner-city children with moderate to severe asthma are sensitized to multiple indoor allergens and that environmental factors known to be associated with asthma severity are commonly present in their homes. The intervention developed for the Inner-City Asthma Study employs accepted methods to address an array of allergens and ETS exposure while ensuring that the intervention is tailored to the specific sensitization profiles and home characteristics of these children.

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“…Among foreign studies, Arshad et al (41) showed that the most frequent allergen in children aged <4 years old with AR was house dust mites (40%). In the US, particularly in regions with dense apartment buildings, children stay indoors for long periods and thus experience more exposure to indoor allergens, leading to increased sensitivity to house dust mites and other indoor allergens (44).…”

Section: Discussionmentioning

confidence: 99%

Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey

Elmas¹,

Özdemir²

2017

JAREM

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Objective: Sensitization prevalence studies have been rarely reported in children with allergic rhinitis from different regions of Turkey, and the exact rates of some sensitizations in humid regions such as Sakarya are still unknown. The aim of this study was to explore what kind of allergens play a role in sensitizations of allergic rhinitis patients during childhood in the Sakarya province of Turkey.Methods: This cross-sectional study involves 623 patients, 1-18 years of age, who have allergic rhinitis symptoms and were referred to the only pediatric allergy outpatient clinic in Sakarya between May 2013 and June 2015. Firstly, a questionnaire containing demographic data and patient history was completed. The multiple skin prick test system was used to detect sensitization. With 0 x 0 mm negative control, any positive test result with an allergen was defined as a wheal ≥3 mm diameter.Results: Overall, 289/623 (46%) children showed a positive response. 37% of them were found to have multiple sensitizations. Among the 289 patients, there were sensitizations to pollens (252/289: 87%), mites (51%), grasses (66%), trees (21%), molds (8%), animals (6%), and foods (6%). Sensitizations above 5 years of age were as follows: grasses, 72% (168/233); mites, 49.4%; trees, 24.5%; molds, 6.9%; and animals, 6%. Under 5 years were as follows: mites, 59% (33/56); grasses, 42.9%; foods, 25%; molds, 10.7%; trees, 5.4%; and animals, 3.6%.Conclusion: There were significant sensitizations detected for pollens and mites. Overall, a lower sensitization (8%) to molds is found in our patients who were referred to us from the humid Sakarya province.

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Atopic profile of inner-city asthma with a comparative analysis on the cockroach-sensitive and ragweed-sensitive subgroups

Cited by 88 publications

References 27 publications

The Environment and Asthma in US Inner Cities

The Environment and Asthma in US Inner Cities

Home and allergic characteristics of children with asthma in seven U.S. urban communities and design of an environmental intervention: the Inner-City Asthma Study.

Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey

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