Atopic myelitis: first case report outside Japan?

Zoli, Alessandra; Mariano, Maria; Fusari, A.; Bonifazi, Francesca; Antonicelli, Leonardo

doi:10.1111/j.1398-9995.2004.00689.x

Cited by 18 publications

(20 citation statements)

References 8 publications

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“…10J ). Although interferon regulatory factor-8 (IRF8) (Masuda et al, 2012) and satellite cells (Xu et al, 2013) are thought to be involved in PNI-related allodynia, we did not observe positive staining of IRF8 in microglia (Fig. 11A), or satellite cell activation in DRG (Fig.…”

Section: Endothelin-1 and Its Receptor Are Upregulated In Atopy Modelmentioning

confidence: 79%

“…Although careful interpretation is needed for such data, microglial and astroglial activation coinciding with development of allodynia was strikingly consistent in asthma model mice, even compared with the Alum groups. However, neither IRF8 (Tsuda et al, 2003) nor DRG satellite glia (M.H. Chen et al, 2014) appeared contributory, suggesting a distinct cascade from PNI-related allodynia to be operative in atopy-related allodynia.…”

Section: Discussionmentioning

confidence: 99%

“…The aim of this study was to determine how atopy exerts substantial influence on the nociceptive system. We first studied the influence of atopy on spinal cord microglia and astroglia in atopy model mice because both types of glia play critical roles in induction and maintenance of persistent neuropathic pain in peripheral nerve injury (PNI) animal models (Tsuda et al, 2003;G. Chen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation

et al. 2016

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Allergic and atopic disorders have increased over the past few decades and have been associated with neuropsychiatric conditions, such as autism spectrum disorder and asthmatic amyotrophy. Myelitis presenting with neuropathic pain can occur in patients with atopic disorder; however, the relationship between allergic inflammation and neuropathic pain, and the underlying mechanism, remains to be established. We studied whether allergic inflammation affects the spinal nociceptive system. We found that mice with asthma, atopic dermatitis, or atopic diathesis had widespread and significantly more activated microglia and astroglia in the spinal cord than those without atopy, and displayed tactile allodynia. Microarray analysis of isolated microglia revealed a dysregulated phenotype showing upregulation of M1 macrophage markers and downregulation of M2 markers in atopic mice. Among the cell surface protein genes, endothelin receptor type B (EDNRB) was most upregulated. Immunohistochemical analysis revealed that EDNRB expression was enhanced in microglia and astroglia, whereas endothelin-1, an EDNRB ligand, was increased in serum, lungs, and epidermis of atopic mice. No EDNRA expression was found in the spinal cord. Expression of FBJ murine osteosarcoma viral oncogene homolog B was significantly higher in the dorsal horn neurons of asthma mice than nonatopic mice. The EDNRB antagonist BQ788 abolished glial and neural activation and allodynia. We found increased serum endothelin-1 in atopic patients with myelitis and neuropathic pain, and activation of spinal microglia and astroglia with EDNRB upregulation in an autopsied case. These results suggest that allergic inflammation induces diffuse glial activation, influencing the nociceptive system via the EDNRB pathway.

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Section: Endothelin-1 and Its Receptor Are Upregulated In Atopy Modelmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation

et al. 2016

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“…Most AM patients have been investigated in Japan, with very few cases of AM being reported in western countries [8,9]. It has been unclear whether AM was as frequent in other Asian countries as in the case of Hirayama disease and whether it was a distinct entity, different from other idiopathic myelitis disorders, multiple sclerosis or neuromyelitis optica (NMO).…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory characteristics of atopic myelitis: Korean experience

Yoon

Joo

et al. 2009

Journal of the Neurological Sciences

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“…Although initially described in Japan, cases of atopic myelitis have been described in European patients (Zoli et al, 2005;Gregoire et al, 2006). Interestingly, several patients with atopic myelitis have developed focal amyotrophy, suggesting a potential link between atopic myelitis and Hopkin's syndrome, a rare poliomyelitis-like illness associated with acute asthma in children (Hopkins, 1974;Kira et al, 2008).…”

Section: Atopic Myelitis (Kira's Disease)mentioning

confidence: 99%

Acute inflammatory myelopathies

Cree

2014

Handbook of Clinical Neurology

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Atopic myelitis: first case report outside Japan?

Cited by 18 publications

References 8 publications

Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation

Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation

Clinical and laboratory characteristics of atopic myelitis: Korean experience

Acute inflammatory myelopathies

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