Atopic Dermatitis: Update and Proposed Management Algorithm

Garnacho‐Saucedo, Gloria; Salido‐Vallejo, Rafael; Moreno‐Giménez, J.C.

doi:10.1016/j.adengl.2012.11.001

Cited by 20 publications

(14 citation statements)

References 71 publications

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“…The most complex cases often require treatment with photochemotherapy, systemic corticosteroids, and/or immunosuppressants, sometimes in combination. 1,2 Phototherapy has been widely used in AD since the 1970s. Over the years, various modalities of phototherapy with UV light have been introduced, namely psoralen plus UV-A (PUVA or photochemotherapy), broadband UV-B (BB UV-B, 280-315 nm), narrowband UV-B (NB UV-B, peak = 311 nm), UV-A (315-400 nm), UV-A1 (340-400 nm), and UV-AB (UV-A followed by UV-B or simultaneous exposure to both).…”

Section: Introductionmentioning

confidence: 99%

“…1 Therapeutic guidelines encourage an individualized approach to treating AD and include recommendations on skin moisturizing, corticosteroids and/or topical calcineurin inhibitors, systemic antihistamines, and topical or systemic antibiotics, when required. The most complex cases often require treatment with photochemotherapy, systemic corticosteroids, and/or immunosuppressants, sometimes in combination.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phototherapy in Atopic Dermatitis: A Systematic Review of the Literature

Pérez‐Ferriols

Aranegui

Pujol-Montcusí

et al. 2015

Actas Dermo-Sifiliográficas (English Edition)

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There is evidence for the use of narrow-band UV-B and UV-A1 phototherapy in moderate to severe atopic dermatitis. Evidence supporting the use of PUVA in atopic dermatitis is scarce and there is little information on the use of phototherapy in childhood. For the purpose of future studies, it would be advisable to use comparable criteria and scales for the evaluation of disease severity and patients, to standardize radiation methods, and to establish a minimum follow-up time.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phototherapy in Atopic Dermatitis: A Systematic Review of the Literature

Pérez‐Ferriols

Aranegui

Pujol-Montcusí

et al. 2015

Actas Dermo-Sifiliográficas (English Edition)

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“…Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease caused by a combination of genetic and environmental factors, and involves a complex interaction between epidermal barrier dysfunction and dysregulation of innate and adaptive immunity, interleukin‐1 family signaling, and regulatory T cells …”

Section: Introductionmentioning

confidence: 99%

The association between atopic dermatitis and serum 25‐hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features—A cross‐sectional study

Sanmartín¹,

Pardos

Doste³

et al. 2020

Pediatric Dermatology

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Background Previous studies have linked low serum vitamin D (VD) or 25‐hydroxyvitamin D (25(OH)D) levels with increased severity of atopic dermatitis (AD) in children. Objective To investigate the association between serum VD (25(OH)D) levels and AD and AD severity, considering the influence of diet and sun exposure. Methods We performed a prospective cross‐sectional study of healthy controls and children diagnosed with AD. Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun‐induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test. Results The study population consisted of 105 healthy controls and 134 AD patients. Serum 25(OH)D levels were significantly lower in moderate and severe AD than in mild AD, although this association was only significant for patients with light Fitzpatrick skin type (mean(SD) 36.7 (11.9) ng/mL; moderate 28.8 [11.5] ng/mL; and severe 27.6 [12.1] ng/mL, P = .045). Logistic regression analysis revealed a positive association between severe AD and both positive ImmunoCAP Phadiatop test and BMI. Conclusion Our data support an association between VD deficiency and AD severity only in patients with light complexion.

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“…Limited studies have investigated the association between atopic dermatitis (AD), also termed eczema , and squamous cell carcinoma (SCC). A chronic, inflammatory disease, AD causes scaly, pruritic patches and plaques on the skin and affects up to 20% of children and 3% of adults worldwide . The prevalence of AD has tripled since the 1960s, with new diagnoses of AD occurring at about 11% per year in the United States .…”

Section: Introductionmentioning

confidence: 99%

“…A chronic, inflammatory disease, AD causes scaly, pruritic patches and plaques on the skin 1 and affects up to 20% of children and 3% of adults worldwide. 2 The prevalence of AD has tripled since the 1960s, with new diagnoses of AD occurring at about 11% per year in the United States. 3 Alongside the rising incidence of AD, the incidence of nonmelanoma skin cancer (NMSC) is also increasing worldwide.…”

Section: Introductionmentioning

confidence: 99%