Atopic dermatitis: quality of life of young Italian children and their families and correlation with severity score

Ricci, Giampaolo; Bendandi, Barbara; Bellini, Federica; Patrizi, Annalisa; Masi, Massimo

doi:10.1111/j.1399-3038.2006.00502.x

Cited by 101 publications

(118 citation statements)

References 11 publications

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“…Notwithstanding the limitations described, the profile described here is compatible with the majority of AD patients in other studies. 21,22 The comparison between clinical disease severity and parent-assessed severity indicated a weak correlation with mild and moderate forms of the disease. 25 There was also a significant impact on the quality of life of our study population in the domain covering the influence of AD on mood.…”

Section: Resultsmentioning

confidence: 99%

Qualidade de vida em pacientes pediátricos com dermatite atópica

Alvarenga¹,

Caldeira²

2009

J. Pediatr. (Rio J.)

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Objective: To measure the impact of atopic dermatitis (AD) on the quality of life of pediatric patients and their families, establishing correlations with scores of disease severity. Methods:This was an observational study of the correlations between clinical indicators of severity and two questionnaires on quality of life: IDQOL and DFI. The study also included scoring of eczema severity -EASI. Fortytwo children with AD, fulfilling established diagnostic criteria, and 44 children with other dermatologic diseases were investigated for the effect of eczema on quality of life. Pearson's correlation was used for the correlation analysis and the comparison between the groups was carried out using the Mann-Whitney test.Results: Data analysis demonstrated significant differences between the scores for the two groups. The mean score in the eczema group was 9.2 (range 1-19) for IDQOL and 8.5 (range 0-17) for DFI. The highest scoring questions for IDQOL referred to itching and scratching, mood changes and problems caused by treatment. For the FDI, the highest impact domains were treatment-related expenditure and sleep disturbance affecting family members.Conclusions: AD has a negative impact on the quality of life of pediatric patients and their families. Data obtained in studies of quality of life in AD should be used to guide clinical practice in order to identify individual treatment strategies and should lead to the adoption of measures to reduce the impact of the disease on patients and their families.J Pediatr (Rio J). 2009;85(5):415-420: Quality of life, atopic dermatitis, children.

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Section: Resultsmentioning

confidence: 99%

Qualidade de vida em pacientes pediátricos com dermatite atópica

Alvarenga¹,

Caldeira²

2009

J. Pediatr. (Rio J.)

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“…A restrição do estudo aos pacientes do SUS também representa uma limitação, pois não permitiu a inserção de pacientes de níveis socioeconômicos superiores. Em contrapartida às referidas limitações, cumpre destacar que o perfil estudado é compatível com a maioria dos pacientes com DA de outros estudos 21,22 .…”

Section: Discussionunclassified

“…As questões de menor impacto referem-se à interferência da DA nas atividades familiares e ao desconforto ao vestir e despir a criança 21,22 . No presente estudo, o domínio do IDQOL que apresentou maiores escores foi também aquele relacionado ao prurido, estando em concordância com a literatura mundial, que considera bem estabelecida a correlação entre prurido e qualidade de vida.…”

Section: Discussionunclassified

Quality of life in pediatric patients with atopic dermatitis

Alvarenga¹,

Caldeira²

2009

J Pediatr (Rio J)

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Objective: To measure the impact of atopic dermatitis (AD) on the quality of life of pediatric patients and their families, establishing correlations with scores of disease severity. Methods:This was an observational study of the correlations between clinical indicators of severity and two questionnaires on quality of life: IDQOL and DFI. The study also included scoring of eczema severity -EASI. Forty-two children with AD, fulfilling established diagnostic criteria, and 44 children with other dermatologic diseases were investigated for the effect of eczema on quality of life. Pearson's correlation was used for the correlation analysis and the comparison between the groups was carried out using the Mann-Whitney test.Results: Data analysis demonstrated significant differences between the scores for the two groups. The mean score in the eczema group was 9.2 (range 1-19) for IDQOL and 8.5 (range 0-17) for DFI. The highest scoring questions for IDQOL referred to itching and scratching, mood changes and problems caused by treatment. For the FDI, the highest impact domains were treatment-related expenditure and sleep disturbance affecting family members.Conclusions: AD has a negative impact on the quality of life of pediatric patients and their families. Data obtained in studies of quality of life in AD should be used to guide clinical practice in order to identify individual treatment strategies and should lead to the adoption of measures to reduce the impact of the disease on patients and their families. J Pediatr (Rio J)

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“…1 Disturbed sleep is frequently reported by the patients and their family and is a major factor leading to an impaired quality of life. [2][3][4] Sleep disturbance can have many negative consequences, including impaired neurocognitive function, higher rates of behavioral problems, and changes in mood. 5,6 Therefore, the recognition and proper management of sleep disturbance should be an important issue in AD.…”

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confidence: 99%

Atopic Dermatitis, Melatonin, and Sleep Disturbance

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: Sleep disturbance affects 47% to 60% of children with atopic dermatitis and is a leading cause of impaired quality of life for the patients and their family. WHAT THIS STUDY ADDS:Sleep disturbance in children with atopic dermatitis can be predicted by a Scoring Atopic Dermatitis index of $48.7, and lower nocturnal melatonin secretion might play a role in the pathophysiology. abstract BACKGROUND AND OBJECTIVES: Sleep disturbance is common in patients with atopic dermatitis (AD). However, studies have largely been questionnaire-based, and the pathophysiology remains unclear. The aims of this study were to determine objective characteristics of sleep disturbance in children with AD and explore contributing factors and clinical predictors.METHODS: Sleep parameters were measured by actigraphy and polysomnography in 72 patients with AD and 32 controls ages 1 to 18 years. Urinary 6-sulfatoxymelatonin levels, serum cytokines, and total and allergen-specific immunoglobulin E (IgE) levels were also measured. RESULTS:The patients with AD had significantly reduced sleep efficiency, longer sleep onset latency, more sleep fragmentation, and less nonrapid eye movement sleep. Results from actigraphy correlated well with those from polysomnography. The AD disease severity was associated with sleep disturbance (r = 0.5520.7), and a Scoring Atopic Dermatitis index of $48.7 predicted poor sleep efficiency with a sensitivity of 83.3% and a specificity of 75% (area under the curve = 0.81, P = .001). Lower nocturnal melatonin secretion was significantly associated with sleep disturbance in the patients with AD. Other correlates of sleep disturbance included pruritus, scratching movements, higher total serum IgE levels, and allergic sensitization to dust mite and staphylococcal enterotoxins. CONCLUSIONS:Poor sleep efficiency is common in children with AD and can be predicted by the Scoring Atopic Dermatitis index. Melatonin and IgE might play a role in the sleep disturbance. Further studies are required to explore the mechanisms and clinical implications, and actigraphy could serve as a useful evaluating tool. Atopic dermatitis (AD) is a common chronically relapsing pruritic inflammatory skin disease. 1 Disturbed sleep is frequently reported by the patients and their family and is a major factor leading to an impaired quality of life. [2][3][4] Sleep disturbance can have many negative consequences, including impaired neurocognitive function, higher rates of behavioral problems, and changes in mood. 5,6 Therefore, the recognition and proper management of sleep disturbance should be an important issue in AD.The sleep disturbance in AD might be due to the pruritus and scratching movements during sleep, 7-10 but it is likely that other factors are involved. 11 Melatonin is a hormone secreted by the pineal gland that is essential for regulating the circadian rhythm. 12 Dysfunction in the diurnal secretion of melatonin in patients with AD has been reported, 13 but its association with their sleep disturbance has...

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Atopic dermatitis: quality of life of young Italian children and their families and correlation with severity score

Cited by 101 publications

References 11 publications

Qualidade de vida em pacientes pediátricos com dermatite atópica

Qualidade de vida em pacientes pediátricos com dermatite atópica

Quality of life in pediatric patients with atopic dermatitis

Atopic Dermatitis, Melatonin, and Sleep Disturbance

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