Atopic dermatitis: correlation between non‐damaged skin barrier function and disease activity

Addor, Flávia Alvim Sant’Anna; Takaoka, Roberto; Rivitti, Evandro A.; Aoki, Valéria

doi:10.1111/j.1365-4632.2011.05176.x

Cited by 48 publications

(39 citation statements)

References 22 publications

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“…In fact, low capacitance was in agreement with a reduced SC water content following tissue-tolerable plasma application in the study by Fluhr et al [51]. Moreover, in the study by Mlitz et al [43 ]on mild-to-moderate AD and in several others in the literature [49,62,63], capacitance correlated with the clinical assessment of disease severity in AD, a condition in which dry skin is one of the major hallmarks. Conductance correlated with the SC water content in facial skin, characterized by high hydration [37].…”

Section: Resultssupporting

confidence: 67%

Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

Falcone

Uzunbajakava²,

Varghese

et al. 2015

Skin Pharmacol Physiol

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Skin barrier function, confined to the stratum corneum, is traditionally evaluated using established, noninvasive biophysical methods like transepidermal water loss, capacitance and conductance. However, these methods neither measure skin molecular composition nor its structure, hindering the actual causes of skin barrier change or impairment. At the same time, confocal Raman microspectroscopy (CRS) can directly measure skin molecular composition and structure and has proven itself to be a powerful technique for biomolecular analysis. The aims of this literature review were to evaluate noninvasive biophysical methods in view of CRS and to outline a direction towards more specific and informative skin measurement methods. We address this by investigating, for the first time, the relation between in vivo assessment of the skin barrier using indirect biophysical methods and the actual skin composition and structure as given by CRS, and emphasize the high potential of CRS for dermatology and cosmetic sciences. CRS acceptance in these fields will require close collaboration between dermatologists, skin scientists and spectroscopy experts towards simplifying the technology and creating robust, rapid, easy-to-use and less expensive CRS applications.

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Section: Resultssupporting

confidence: 67%

Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

Falcone

Uzunbajakava²,

Varghese

et al. 2015

Skin Pharmacol Physiol

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“…The importance of TEWL as a measure of skin barrier function has been widely acknowledged. Therefore, an inflammatory state such as atopic dermatitis, which results in a decrease in barrier function, indicates a higher TEWL value (26). Our results demonstrated that sleep efficiency significantly varied from Q1 to Q4, indicating an association between lower sleep efficiency and the attenuation of barrier function.…”

Section: Discussionmentioning

confidence: 50%

Association between Skin Condition and Sleep Efficiency in Japanese Young Adults

Yoshizaki

Kimira

Mano

et al. 2017

J Nutr Sci Vitaminol

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Summary There has been little epidemiological evidence that has comprehensively clarified whether alterations in lifestyle, such as sleep quality and dietary intake, explain changes in the skin condition of healthy young adults. Therefore, the aim of our study was to elucidate the association between skin condition and lifestyle behaviors such as diet and sleep, after statistically controlling confounding factors. The subjects were 54 participants who were aged 20-32 y, and who attended college in the Kanto region (in Japan). Transepidermal water loss (TEWL) was obtained by putting a probe on the skin surface based on the European Society of Contact Dermatitis guidelines for TEWL measurements. Self-administered questionnaires on demographic characteristics, dietary habits, and health status, such as sleep condition, depression, and fatigue, were handed to participants on the day of measurement. We found that lower sleep efficiency was significantly associated with higher TEWL (p50.023), while other demographic factors, dietary intakes, and eating behaviors were not (p.0.05). This significant association remained unchanged after controlling for confounding variables, such as sex, BMI, and dietary intake. Our findings may have important implications in the development of valuable health strategies that may suggest behavior modifications for young to middle-aged men and women.

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“…Increased oxidative stress has been documented in affected skin of individuals suffering from atopic dermatitis (AD)1–4 and seems to be involved in inflammation, skin-barrier impairment, and itch. Moreover, measurements of transepidermal water loss and corneometry have shown an inverse relation to AD severity 5. In addition, patients with AD display an augmented susceptibility to cutaneous bacterial, fungal, and viral infections 6,7.…”

Section: Introductionmentioning

confidence: 99%

Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis

Wiegand

Hipler²,

Boldt³

et al. 2013

CCID

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Atopic dermatitis (AD) is a chronic inflammatory disease characterized by the impairment of the skin-barrier function, increased oxidative cellular stress, and bacterial colonization. Hence, medical therapies of AD aim to control infection, reduce inflammation, and restore skin-barrier function by use of topical and systemic antibacterial drugs, topical corticosteroids, topical calcineurin inhibitors, and moisturizers. Textiles have the longest and most intense contact with the human skin, and functional textiles with intrinsic properties such as antioxidative capacity and antibacterial activity have been gaining in importance in medical applications. Specially designed textiles may support AD treatment and improve quality of life of AD. Here, we investigated the role of ZnO-functionalized textile fibers in the control of oxidative stress in AD in vitro and in vivo. In addition, the antibacterial effect and biocompatibility of the Zn textile was evaluated in vitro. We observed a rapid improvement of AD severity, pruritus, and subjective sleep quality when AD patients wore the ZnO textiles overnight on 3 consecutive days. This is possibly due to the high antioxidative capacity of the ZnO textile, as well as the allocation of strong antibacterial activity. Moreover, it was shown that the ZnO textiles possess very good biocompatibility and were well tolerated by AD patients.

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Atopic dermatitis: correlation between non‐damaged skin barrier function and disease activity

Abstract: Biophysical measurements of skin barrier in non-lesional skin of AD may work as an evaluation factor for AD severity.

Cited by 48 publications

References 22 publications

Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

Association between Skin Condition and Sleep Efficiency in Japanese Young Adults

Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis

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