Atomoxetine-induced mania in an adolescent patient

Bahalı, Kayhan; Üneri, Özden Şükran; İpek, Hamiyet

doi:10.1016/j.neurenf.2012.04.328

Cited by 7 publications

(11 citation statements)

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“…Second, atomoxetine-induced psychosis or mania in previously reported adolescent cases were managed by total discontinuation of the medication (Henderson 2004;Tang et al 2009;Bahali et al 2013;Guney and Uneri 2014). In contrast, the psychotic symptoms of our case resolved completely after we tapered down atomoxetine dosage instead of discontinuing it totally.…”

Section: Discussionmentioning

confidence: 57%

“…Family history or personal history of mood disorders or medication-induced mood instability may be an important risk factor for atomoxetine-induced mania, as has been pointed out by previous reports (Henderson 2004;Bahali et al 2013). Patients with ADHD in childhood and adolescence have increased risk of bipolar disorder or schizophrenia later in life (Dalsgaard, et al 2014;Dalteg et al 2014), and this may be because of some shared genetic factors among these disorders (Larsson et al 2013).…”

Section: Discussionmentioning

confidence: 86%

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Atomoxetine-Induced Mania with Auditory Hallucination in an 8-Year-Old Boy with Attention-Deficit/Hyperactivity Disorder and Tic Disorder

Liu

Lan

Chen

2014

Journal of Child and Adolescent Psychopharmacology

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 86%

Atomoxetine-Induced Mania with Auditory Hallucination in an 8-Year-Old Boy with Attention-Deficit/Hyperactivity Disorder and Tic Disorder

Liu

Lan

Chen

2014

Journal of Child and Adolescent Psychopharmacology

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“…Conversely, the literature on children and adolescents with ADHD has several documented reports of atomoxetine-induced (hypo) mania. [ 13 14 15 16 17 18 ] In an uncontrolled open trial, about one-third (33%) of ADHD children receiving atomoxetine reported irritability, hypomania, mania, and aggression. In this study, the majority of the affected children experiencing above-mentioned adverse effects had family or history suggestive of mood disorder or symptoms.…”

Section: Discussionmentioning

confidence: 99%

Atomoxetine Induced Hypomania in a Patient with Bipolar Disorder and Adult Attention Deficit Hyperactivity Disorder

Kumar

Varambally

2017

Indian Journal of Psychological Medicine

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Comorbidity of bipolar disorder (BD) with attention deficit hyperactivity disorder (ADHD) is frequent. The management of comorbid ADHD and BD is complicated by the risk of induction of (hypo) mania by the medications used for ADHD treatment. Earlier reports in children and adolescents with ADHD-BD suggest that the possibility of (hypo) mania induction is low when atomoxetine is used along mood stabilizers or antipsychotics. Here, we report induction of hypomania by atomoxetine when used for the treatment of comorbid ADHD in a BD patient while on prophylactic treatment with mood stabilizers. This report indicates that atomoxetine carries the risk of induction of (hypo) mania even in stabilized BD patients. Clinicians should closely monitor such patients for (hypo) mania symptoms.

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“…However, five case reports described hypomanic or manic switches with atomoxetine. [ 75 , 76 , 77 , 78 , 79 ] Therefore, precautionarily, both the European summary of product characteristics and the US label state that treatment-emergent mania “without a prior history of psychotic illness or mania can be caused by atomoxetine at usual doses” [ 80 ].…”

Section: Treatment Implications Of Adhd–bd Comorbiditymentioning

confidence: 99%

ADHD and Bipolar Disorder in Adulthood: Clinical and Treatment Implications

et al. 2021

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Attention deficit hyperactivity disorder (ADHD) is a condition that usually has its onset in childhood. Although the disorder persists into adulthood in half of cases, adult ADHD is often not recognized due to different psychopathological characteristics, quite often overlapping with other diagnoses such as mood, anxiety and personality disorders. This is especially true for bipolar disorder (BD), which shares several symptoms with adult ADHD. Moreover, besides an overlapping clinical presentation, BD is often co-occurring in adults with ADHD, with comorbidity figures as high as 20%. This review will focus on the comorbidity between ADHD and BD by exploring the magnitude of the phenomenon and evaluating the clinical and functional characteristics associated with ADHD–BD comorbidity in adults. Finally, the review will address the implications of pharmacologically treating the ADHD–BD comorbidity, providing suggestions in how to treat these complex patients and addressing the issue of treatment-induced manic switch with the use of stimulants and other medications for ADHD.

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Atomoxetine-induced mania in an adolescent patient

Cited by 7 publications

References 0 publications

Atomoxetine-Induced Mania with Auditory Hallucination in an 8-Year-Old Boy with Attention-Deficit/Hyperactivity Disorder and Tic Disorder

Atomoxetine-Induced Mania with Auditory Hallucination in an 8-Year-Old Boy with Attention-Deficit/Hyperactivity Disorder and Tic Disorder

Atomoxetine Induced Hypomania in a Patient with Bipolar Disorder and Adult Attention Deficit Hyperactivity Disorder

ADHD and Bipolar Disorder in Adulthood: Clinical and Treatment Implications

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