Atom arrangement strategy for designing a turn-on¹H magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite

Abstract

The first dual activatable hypochlorite ((-)OCl)-sensing probe was developed, based on a new proof-of-concept design involving signal-activatable (1)H chemical probes using the triple-resonance NMR technique. The probe enabled fluorescence-(1)H MR dual turn-on detection of (-)OCl in solution and in crude tissue extracts.

Polymeric 1H MRI Probes for Visualizing Tumor In Vivo

“…More recently, other groups have developed the signal turn-on strategy using a combination of 1 H-{ 13 C-13 C '} triple-resonance NMR and a 13 C-enriched probe for selective sensing of biochemical reactions, such as glucose-to-lactate metabolism, [44] dopamine oxidation, [45] and reactive oxygen species. [46] 6.2. Multiple-resonance (triple-resonance in particular) techniques allowed the specific monitoring of stable isotopeenriched probes in complex biological systems with remarkable selectivity.…”

“…More recently, other groups have developed the signal turn-on strategy using a combination of 1 H-{ 13 C-13 C'} triple-resonance NMR and a 13 C-enriched probe for selective sensing of biochemical reactions, such as glucose-to-lactate metabolism, [44] dopamine oxidation, [45] and reactive oxygen species. [46]…”

“…These results clearly demonstrated that the perfect selectivity of 1D 1 H–{ 13 C– 15 N} triple–resonance NMR allowed the unambiguous and quantitative metabolic and pharmacokinetic ex vivo analyses of 13 C/ 15 N–enriched probe in mice. More recently, other groups have developed the signal turn–on strategy using a combination of 1 H–{ 13 C– 13 C'} triple–resonance NMR and a 13 C–enriched probe for selective sensing of biochemical reactions, such as glucose–to–lactate metabolism, dopamine oxidation, and reactive oxygen species …”

Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores

“…Additionally, chromone derivatives have also been found to exhibit a range of interesting fluorescent properties (Miao et al, 2015;Chen et al, 2021). Series 1 (R1, R2, R3) and series 2 (Ra, Rb, Rc) were designed as redox Doura et al, 2012;Wang et al, 2020). Series 3 (N1, N2) and series 4 (N3, N4) are the probes that were designed with a non-redox mechanism, and the 7-donor groups were modified with the boronate group (series 3) or sulfonyl ester group (series 4).…”

“…phosphate buffer with 0.15 M NaCl (pH 7.4) at 37 °C for 5 min (Doura et al, 2012;Xing et al, 2016;Zhan et al, 2017). Because O 2…”