Polymeric ¹H MRI Probes for Visualizing Tumor In Vivo

Abstract

Magnetic resonance imaging (MRI) has become a prominent non- or low-invasive imaging technique, providing high-resolution, three-dimensional images as well as physiological information about tissues. Low-molecular-weight Gd-MRI contrast agents (CAs), such as Gd-DTPA (DTPA: diethylenetriaminepentaacetic acid), are commonly used in the clinical diagnosis, while macromolecular Gd-MRI CAs have several advantages over low-molecular-weight Gd-MRI CAs, which help minimize the dose of CAs and the risk of side effects. Accordingly, we developed chiral dendrimer Gd-MRI CAs, which showed high r values. The association constant values (K ) of S-isomeric dendrimer CAs to bovine serum albumin (BSA) were higher than those of R-isomeric dendrimer CAs. Besides, based on a totally new concept, we developed C/ N-enriched multiple-resonance NMR/MRI probes, which realized highly selective observation of the probes and analysis of metabolic reactions of interest. This account summarizes our recent study on developing both chiral dendrimer Gd-MRI CAs, and self-traceable C/ N-enriched phosphorylcholine polymer probes for early detection of tumors.

Synergistically Enhanced Chemodynamic Therapy Induced by NIR-II Photothermal Therapy with MRI/CT Imaging Guidance for Colorectal Cancer

“…Additionally, imaging-guided treatment strategies have been shown to be highly effective in pinpointing the exact location of tumors, leading to better treatment outcomes and a reduction in adverse reactions. − For instance, the amphiphilic diketopyrrolopyrrole derivative (ADDPPP) can be regarded as a fluorescent molecular probe for guiding NIR PTT, which observably enhances the inhibition effect of tumors . Surprisingly, magnetic resonance imaging (MRI) is a medical technology that offers multiplanar capabilities and is widely applied for the noninvasive diagnosis of colorectal cancer in clinical practice. , Computed tomography (CT) provides high-resolution images of tissue microstructure by measuring the X-ray attenuation coefficient characteristics. , Some reports have suggested that a clinical strategy combining MRI with CT may be a preferred option for the provision of more accurate diagnostic information for CRC. , …”

“…31 Surprisingly, magnetic resonance imaging (MRI) is a medical technology that offers multiplanar capabilities and is widely applied for the noninvasive diagnosis of colorectal cancer in clinical practice. 32,33 Computed tomography (CT) provides high-resolution images of tissue microstructure by measuring the X-ray attenuation coefficient characteristics. 34,35 Some reports have suggested that a clinical strategy combining MRI with CT may be a preferred option for the provision of more accurate diagnostic information for CRC.…”