Atividade antioxidante, citotóxica e antimicrobiana de Annona vepretorum Mart. (Annonaceae)

Almeida, Jackson Roberto Guedes da Silva; Araújo, Camila de Souza; Pessoa, Cláudia; Costa, Marcília Pinheiro da; Pacheco, Alessandra Gomes Marques

doi:10.1590/s0100-29452014000500030

Cited by 23 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Phytochemical analysis showed the presence of flavonoids, except in crude hexane extract (Av-HexC), confirming previous studies with A. vepretorum [15]. A large number of biological activities have been attributed to these compounds, including anticancer activity [19].…”

Section: Discussionsupporting

confidence: 87%

“…In addition, research has shown that the ethanol extract has anti-inflammatory and antinociceptive activity, which is related probably with the activation of opioid receptors and inhibition of release of mediators of the inflammatory process [14]. Antioxidant, cytotoxic and antimicrobial activities have also been reported for this plant [15].…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Phytochemical screening, cytotoxicity and acute toxicity of Annona vepretorum Mart (Annonaceae) leaf extracts

Silva¹,

Oliveira²,

Araújo³

et al. 2017

Trop. J. Pharm Res

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 95%

Phytochemical screening, cytotoxicity and acute toxicity of Annona vepretorum Mart (Annonaceae) leaf extracts

Silva¹,

Oliveira²,

Araújo³

et al. 2017

Trop. J. Pharm Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…SF32-33 had a dose- and time-dependent effect on P. aeruginosa ATCC 27853. Indeed, these effects were observed as soon as 6 h post-incubation of SF32-33 and lasted for 24 h. Although antibacterial activity has been attributed to fractions obtained from other plants of the Annona genus ( A. vepretorum and A. hypoglauca ), their MIC and MBC were much higher (≤100 mg/ml; Almeida et al, 2014; Rinaldi et al, 2016) in comparison to those observed for the EAF of A. glabra in our study (≤16 μg/ml).…”

Section: Discussioncontrasting

confidence: 70%

“…The hexane and chloroform fractions obtained from Annona vepretorum leaves display antimicrobial activity against Escherichia coli, Klebsiella pneumoniae , and Staphylococcus aureus (Almeida et al, 2014). Additionally, Rinaldi and collaborators showed that the methanol, dichloromethane, and ethyl acetate fractions (EAFs) obtained from Annona hypoglauca stems inhibited the growth of Staphylococcus aureus and Enterococcus faecalis (Rinaldi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls

et al. 2016

View full text Add to dashboard Cite

Pseudomonas aeruginosa is an important pathogen in opportunistic infections in humans. The increased incidence of antimicrobial-resistant P. aeruginosa isolates has highlighted the need for novel and more potent therapies against this microorganism. Annona glabra is known for presenting different compounds with diverse biological activities, such as anti-tumor and immunomodulatory activities. Although other species of the family display antimicrobial actions, this has not yet been reported for A. glabra. Here, we investigated the antimicrobial activity of the ethyl acetate fraction (EAF) obtained from the leaf hydroalcoholic extract of A. glabra. EAF was bactericidal against different strains of P. aeruginosa. EAF also presented with a time- and concentration-dependent effect on P. aeruginosa viability. Testing of different EAF sub-fractions showed that the sub-fraction 32-33 (SF32-33) was the most effective against P. aeruginosa. Analysis of the chemical constituents of SF32-33 demonstrated a high content of flavonoids. Incubation of this active sub-fraction with P. aeruginosa ATCC 27983 triggered an endothermic reaction, which was accompanied by an increased electric charge, suggesting a high binding of SF32-33 compounds to bacterial cell walls. Collectively, our results suggest that A. glabra-derived compounds, especially flavonoids, may be useful for treating infections caused by P. aeruginosa.

show abstract

“…There is no consensus on the acceptable level of inhibition for natural products when compared with antibiotics standards. Some authors consider only results similar to antibiotics, while others consider with good potential even those with lower levels of inhibitions (Almeida et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of crude extracts and fractions of Vernonia polyanthes Less (assa-peixe) flowers

Waltrich

Hoscheid

Prochnau

2015

Rev. bras. plantas med.

View full text Add to dashboard Cite

Antimicrobial activity of crude extracts and fractions of Vernonia polyanthes Less (assa-peixe) flowers. Vernonia polyanthes, known as "assa-peixe", is a plant native to Brazil, and the decoction or infusion of its flowers, roots and leaves are used in folk medicine, being considered sources of diuretic, balsamic, anti-rheumatic substances, and are used in cases of bronchitis and persistent cough. The aim of the study was to evaluate the antimicrobial activity of the extract/fractions obtained by methanol maceration and infusion of V. polyanthes flower, also including qualitative identification of flower compounds, through phytochemical evaluation, using colorimetric tests. Identification tests for the presence of anthraquinones, tannins, flavonoids, saponins and alkaloids were performed. Microbiological evaluation was made through agar diffusion assay, using Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa as test organisms. From the performed colorimetric tests it was possible to verify the presence of tannins and flavonoids in both extracts. Alkaloids were also observed in the macerated extract. The ethyl acetate fraction from the agar diffusion assay, from both extracts, presented microbial activity over Staphylococcus aureus. It was possible to qualitatively identify the floral compounds, and to show the differences between extraction methods, being methanol considered the best solvent to the extraction.Keywords: Assa-peixe; Cambará; Medicinal plants; Phytochemical profile. RESUMO: Atividade antimicrobiana de extrato bruto e de frações de flores de Vernonia polyanthes Less (assa-peixe).Vernonia polyanthes, conhecida como assa-peixe, é planta nativa do Brasil e suas flores, raízes e folhas, em decocção ou infusão, são empregadas na medicina caseira como diuréticas, balsâmicas, e anti-reumáticas, usadas nos casos de bronquite e tosse persistente. O objetivo do trabalho foi avaliar a atividade antimicrobiana do extrato/ frações obtidos por maceração em metanol e infusão de flores de V. polyanthes, incluindo também a identificação qualitativa dos compostos presentes nas flores, através da avaliação fitoquímica, empregando testes colorimétricos. Foram realizados testes para identificação de antraquinonas, taninos, flavonóides, saponinas e alcalóides. A avaliação microbiológica foi realizada por meio de ensaio de difusão em ágar, empregando Escherichia coli, Staphylococcus aureus e Pseudomonas aeruginosa. A partir dos testes colorimétricos foi possível verificar a presença de taninos e flavonóides em ambos os extratos. Ainda, no extrato macerado, foi observada a presença de alcalóides. No ensaio de difusão em ágar, a fração acetato de etila de ambos os extratos, apresentou atividade antimicrobiana sobre Staphylococcus aureus. Foi possível identificar qualitativamente os compostos da flor, demonstrando diferença entre as técnicas de extração, sendo que o metanol resultou em melhor poder extrativo.

show abstract

Atividade antioxidante, citotóxica e antimicrobiana de Annona vepretorum Mart. (Annonaceae)

Cited by 23 publications

References 10 publications

Phytochemical screening, cytotoxicity and acute toxicity of Annona vepretorum Mart (Annonaceae) leaf extracts

Phytochemical screening, cytotoxicity and acute toxicity of Annona vepretorum Mart (Annonaceae) leaf extracts

Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls

Antimicrobial activity of crude extracts and fractions of Vernonia polyanthes Less (assa-peixe) flowers

Contact Info

Product

Resources

About