Atividade anti-helmíntica dos flavonóides isolados das raízes de Andira anthelmia (Leguminosae)

Silva, Virgínia C. da; Carvalho, Mário Geraldo de; Borba, HH; Silva, Sandra L. C.

doi:10.1590/s0102-695x2008000400013

Cited by 15 publications

(8 citation statements)

References 7 publications

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“…In that study 2.0 mg/kg dose of biochanin A was found to be quite effective in the removal of the total number of A. tetraptera from mice. Therefore, the findings of the current study are also consistent with those of Silva et al (2008) who found significant anthelmintic effects in Biochanin A. In addition, Naguleswaran et al (2006) have also opined that synthetic isoflavones exhibit distinct in vitro effects on Echinococcus metacestodes and protoscoleces, which could potentially be exploited further for the development of novel chemotherapeutical tools against larval-stage Echinococcus infection.…”

Section: Resultssupporting

confidence: 90%

“…Isoflavones, such as genistein and daidzein, are found in a number of plants, including Flemingia vestita which has shown significant anthelmintic effects against many intestinal helminth parasites (Tandon et al 2011). Silva et al (2008) have studied the anthelmintic effects of biochanin A purified from the roots of Andira anthelmia in mice naturally infected by Aspiculuris tetraptera. In that study 2.0 mg/kg dose of biochanin A was found to be quite effective in the removal of the total number of A. tetraptera from mice.…”

Section: Resultsmentioning

confidence: 99%

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In vitro anthelmintic assessment of selected phytochemicals against Hymenolepis diminuta, a zoonotic tapeworm

Vijaya

Yadav

2014

J Parasit Dis

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A large number of medicinal plants are used as herbal remedy for the treatment of helminthic diseases in the developing countries, however, far too little attention has been paid to assess the anthelmintic potentials of chemical compounds that are present in these plants. This study was carried out to assess the in vitro anthelmintic effects of biochanin A, ursolic acid, betulinic acid and betasitosterol which are the major phytochemicals of Trifolium repens, Houttuynia cordata and Lasia spinosa, the traditionally used anthelmintic plants of Northeast India. The in vitro anthelmintic testing of these phytochemicals was undertaken against Hymenolepis diminuta, a zoonotic tapeworm, and their efficacy was compared with a reference drug, praziquantel. The results revealed that except beta-sitosterol, which showed a very weak anthelmintic effect, remaining all other tested compounds possess highly significant (p B 0.001) and dose-dependent anthelmintic effects. Upon exposure to 0.25, 0.50 and 1 mg/ml concentrations of biochanin A, ursolic acid and betulinic acid, the test parasite H. diminuta, at first, showed a paralyzed state which later culminated into their mortality after short time periods. Of all the phytochemicals tested, betulinic acid (1 mg/ml) showed the best anthelmintic effect and caused the mortality of test parasites at 3.4 ± 0.66 h. In conclusion, the results of this study demonstrate for the first time that betulinic acid, biochanin A and ursolic acid possess significant in vitro anthelmintic effects against H. diminuta, a zoonotic tapeworm, and, therefore, these compounds may be exploited further for anthelmintic drug development.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

In vitro anthelmintic assessment of selected phytochemicals against Hymenolepis diminuta, a zoonotic tapeworm

Vijaya

Yadav

2014

J Parasit Dis

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“…These compounds were proposed as biochanin A 7‐ O ‐[β‐ d ‐apiofuranosyl‐(1 → 5)‐β‐ d ‐apiofuranosyl‐(1 → 6)‐β‐ d ‐glucopyranoside] or isomer (Fig. h; Silva et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Phytochemical Characterisation of Green Beans (Phaseolus vulgaris L.) by Using High‐performance Liquid Chromatography Coupled with Time‐of‐flight Mass Spectrometry

Abu‐Reidah

Arráez‐Román

Lozano‐Sánchez

et al. 2012

Phytochemical Analysis

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The phytochemical composition of three different varieties of P. vulgaris L have been characterised using HPLC-ESI-TOF-MS. A total of 72 phytochemical compounds were characterised, 54 being reported in green beans for the first time. Among these were the main flavonoids detected. These results highlight the influence that variety can exert on the quality of phytochemicals. Given that new phytochemical compounds have been characterised, this study offers a useful approach for improving and updating the food-composition tables.

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“…Phenolic acids and flavonoids mitigate diseases associated with oxidative stress [25] and had excellent antioxidant activity in both our in vitro and in vivo experiments. Their anthelmintic activities also provide a potential option for treating nematode infections [26]. The phenolic acids 1,5-dicaffeoylquinic and 3-O-caffeoylquinic identified in both Mix1 (15.37 and 11.31 mg/g, respectively) and Mix2 (6.18 and 6.91 mg/g, respectively) possess antibacterial and anthelmintic activities [27].…”

Section: Discussionmentioning

confidence: 99%

Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep

et al. 2019

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Background Parallel in vitro and in vivo experiments were designed to evaluate promising chemotherapeutic alternatives for controlling haemonchosis in ruminants. In vitro anthelmintic activities (egg hatch test – EHT; larval development test – LDT) of aqueous and methanolic herbal extracts Mix1 and Mix2 were investigated. The in vivo effects of dietary supplementation with Mix1 and Mix2 on the parasitological status, inflammatory response, antioxidant parameters and microbial community of the lambs infected experimentally with Haemonchus contortus were investigated . Lambs were divided into four groups for the in vivo study: uninfected control lambs (C), infected lambs (I), infected lambs supplemented with Mix1 (I + Mix1) and infected lambs supplemented with Mix2 (I + Mix2). The experimental period was 70 days. Results The number of eggs per gram (EPG) of feces was quantified 22, 30, 37, 44, 51, 58, 65 and 70 days post-infection, and mean abomasal worm counts were assessed 70 days post-infection. Quantitative analyses identified 57.3 and 22.2 mg/g phenolic acids, 41.5 and 29.5 mg/g flavonoids and 1.4 and 1.33 mg/g protoberberine-type alkaloids in Mix1 and Mix2, respectively. The methanolic extracts of the herbal mixtures in both in vitro tests had higher anthelmintic effects ( P < 0.01) than the aqueous extracts, but the effects did not differ significantly between Mix1 and Mix2 ( P > 0.05). I + Mix1 and I + Mix2 lowered mean EPGs between 44 and 70 d by 58.1 and 51.6%, respectively. The level of IgG antibodies against H. contortus increased significantly after infection in each infected group. Conclusion These results represent the first monitoring of the in vitro anthelmintic effects of herbal mixtures on H. contortus . The in vivo experiment indicated that the anthelmintic effect was not sufficient for the elimination of parasites, but this herbal treatment may affect the host over a longer term, reducing the parasitic infection in the host.

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Atividade anti-helmíntica dos flavonóides isolados das raízes de Andira anthelmia (Leguminosae)

Cited by 15 publications

References 7 publications

In vitro anthelmintic assessment of selected phytochemicals against Hymenolepis diminuta, a zoonotic tapeworm

In vitro anthelmintic assessment of selected phytochemicals against Hymenolepis diminuta, a zoonotic tapeworm

Phytochemical Characterisation of Green Beans (Phaseolus vulgaris L.) by Using High‐performance Liquid Chromatography Coupled with Time‐of‐flight Mass Spectrometry

Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep

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