Athlete’s Hepatitis in a Young Healthy Marathon Runner

Khan, Hafiz; Phillipose, Jobin; Ahmed, Moiz; Deeb, Liliane

doi:10.1159/000488446

Cited by 2 publications

(2 citation statements)

References 9 publications

(11 reference statements)

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“…On laboratory workup, viral infections such as hepatitis (A, B, C), Epstein-Barr virus, cytomegalovirus, herpes simplex virus, HIV, autoimmune, and metabolic causes were ruled out. Since his blood pressure was stable until day 8 of his hospitalization without any pressor support, ischemic hepatitis was unlikely [ 20 ]. Tylenol toxicity was excluded (levels were less than 5 ug/mL).…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Failure in a COVID-19 Patient Without any Preexisting Liver Disease

Gurala¹,

Moussawi²,

Philipose³

et al. 2020

Cureus

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In December 2019, an outbreak of novel coronavirus started in Wuhan, China, which gradually spread to the entire world. The World Health Organization (WHO) on February 11, 2020, officially announced the name for the disease as coronavirus disease 2019, abbreviated as COVID-19. It is caused by severe respiratory distress syndrome coronavirus 2 (SARS-CoV-2). The WHO declared SARS-CoV-2 as a pandemic on March 11, 2020. SARS-CoV-2 mainly causes fever as well as respiratory symptoms such as cough and shortness of breath. Gastrointestinal/hepatic sequelae such as diarrhea, nausea, vomiting, and elevated liver enzymes have been reported as well. Studies and data so far on coronavirus infections from China, Singapore, and other countries showed that liver enzymes elevation could be seen in 20-50% of cases. More severe disease can correlate with the worsening of liver enzymes. However, acute liver failure in patients with COVID-19 has not been described. Herein we report a case of acute liver failure in an elderly patient with COVID-19 infection who did not have a history of preexisting liver disease.

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Section: Discussionmentioning

confidence: 99%

Acute Liver Failure in a COVID-19 Patient Without any Preexisting Liver Disease

Gurala¹,

Moussawi²,

Philipose³

et al. 2020

Cureus

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“…These processes are similar to those found during and after successful recovery from tissue damage due to insult, such as myocardial infarct 34 . For example, some athletes involved in extreme exercise programs may experience either “athlete’s hepatitis” 35 or cardiac myopathies as a result of either overuse or repeated transient ischemia 36 . We propose that the immune system is modified in a novel way during migration to help remove and repair the physical damage to these tissues caused by overexertion during long distance flight.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Analyses of Heart and Liver Reveal Novel Pathways for Regulating Songbird Migration

Horton

Jensen

Sebastian

et al. 2019

Sci Rep

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Many birds undertake long biannual voyages during the night. During these times of the year birds drastically reduce their amount of sleep, yet curiously perform as well on tests of physical and cognitive performance than during non-migrating times of the year. This inherent physiological protection disappears when birds are forced to stay awake at other times of the year; thus these protective changes are only associated with the nocturnal migratory state. The goal of the current study was to identify the physiological mechanisms that confer protection against the consequences of sleep loss while simultaneously allowing for the increased physical performance required for migration. We performed RNA-seq analyses of heart and liver collected from birds at different times of day under different migratory states and analyzed these data using differential expression, pathway analysis and WGCNA. We identified changes in gene expression networks implicating multiple systems and pathways. These pathways regulate many aspects of metabolism, immune function, wound repair, and protection of multiple organ systems. Consequently, the circannual program controlling the appearance of the migratory phenotype involves the complex regulation of diverse gene networks associated with the physical demands of migration.

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Athlete’s Hepatitis in a Young Healthy Marathon Runner

Cited by 2 publications

References 9 publications

Acute Liver Failure in a COVID-19 Patient Without any Preexisting Liver Disease

Acute Liver Failure in a COVID-19 Patient Without any Preexisting Liver Disease

Transcriptome Analyses of Heart and Liver Reveal Novel Pathways for Regulating Songbird Migration

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