Acute Liver Failure in a COVID-19 Patient Without any Preexisting Liver Disease

Gurala, Dhineshreddy; Moussawi, Hassan Al; Philipose, Jobin; Abergel, Jeffrey

doi:10.7759/cureus.10045

Cited by 21 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the five ALF cases reported, three were from the USA and one from Germany and Qatar each. [43][44][45][46][47] Two of these were young, aged 24 years and 35 years, while the other three were above 50 years of age. Most of these patients were critically ill and a single etiology could not be identified as a cause except in the patient with hepatitis B co-infection, who had acute fulminant hepatitis B infection but only mild COVID-19 pneumonia.…”

Section: Sars-cov-2 and Acute Liver Failurementioning

confidence: 99%

Coronavirus Disease-2019 (COVID-19) and the Liver

Elhence¹,

Vaishnav²,

Biswas³

et al. 2021

Journal of Clinical and Translational Hepatology

View full text Add to dashboard Cite

Within a year of its emergence, coronavirus disease-2019 (COVID-19) has evolved into a pandemic. What has emerged during the past 1 year is that, apart from its potentially fatal respiratory presentation from which the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) derives its name, it presents with a myriad of gastrointestinal (GI) and liver manifestations. Expression of the angiotensinconverting enzyme-2 (ACE-2) receptor throughout the GI tract and liver, which is the receptor for the SARS-CoV-2, may be responsible for the GI and liver manifestations. Besides acting directly via the ACE-2 receptor, the virus triggers a potent immune response, which might have a role in pathogenesis. The virus leads to derangement in liver function tests in close to 50% of the patients. The impact of these derangements in patients with a normal underlying liver seems to be innocuous. Severe clinical presentations include acute decompensation and acute-on-chronic liver failure in a patient with chronic liver disease, leading to high mortality. Evolving data suggests that, contrary to intuition, liver transplant recipients and patients with autoimmune liver disease on immunosuppression do not have increased mortality. The exact mechanism underlying why immunosuppressed patients fare well as compared to other patients remains to be deciphered. With newer variants of COVID-19, which can spread faster than the original strain, the data on hepatic manifestations needs to be updated to keep a step ahead of the virus.

show abstract

Section: Sars-cov-2 and Acute Liver Failurementioning

confidence: 99%

Coronavirus Disease-2019 (COVID-19) and the Liver

Elhence¹,

Vaishnav²,

Biswas³

et al. 2021

Journal of Clinical and Translational Hepatology

View full text Add to dashboard Cite

show abstract

“…Although respiratory symptoms are the most common in the course of COVID-19 infection, the complicated course of this disease may also lead to impairment of the functions of other organs. Among gastrointestinal symptoms, nausea, vomiting and diarrhoea were the most common during COVID-19 infection [33]; however, many reports also discuss the impact of SARS-CoV2 on many different types of liver dysfunction [34,35,36,37,38,39,40,41,42,43,44,45,46].…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Acute liver injury in the course of COVID-19

Grzywa-Celińska¹,

Emeryk-Maksymiuk²,

Szewczyk³

et al. 2021

Ann Agric Environ Med.

View full text Add to dashboard Cite

Although coronavirus disease 19 (COVID-19) most often affects the respiratory system, in the course of this disease, dysfunction of many other organs may also develop. The case is presented of a female patient, treated for a long time due to chronic obstructive pulmonary disease, complicated by chronic complete respiratory failure, and who was undergoing non-invasive mechanical ventilation at home. She was admitted to the Pneumonology Department due to exacerbation of the symptoms of her underlying disease. Several tests for SARS-CoV2 infection gave a negative result. During the patient's stay in the clinic, a rapid increase was observed in symptoms of respiratory failure, heart failure, and laboratory signs of acute liver damage. The next PCR test result proved to be positive. In addition to the case report, the possible impact of SARS-CoV2 infection on liver damage is also also discussed, along with a literature review on this topic.

show abstract

“…To date, no case of acute liver failure (ALF) has been proven to be directly caused by COVID-19. There is only one suspected case of ALF in the context of coronavirus infection[ 101 ]. Approximately 3% of all cases of COVID-19 and 3.9% of those with severe COVID-19 have pre-existing chronic liver diseases[ 97 , 100 ].…”

Section: Liver-related Manifestations In Patients With Covid-19mentioning

confidence: 99%

COVID-19 infection and liver injury: Clinical features, biomarkers, potential mechanisms, treatment, and management challenges

Sivandzadeh¹,

Askari²,

Safarpour³

et al. 2021

WJCC

View full text Add to dashboard Cite

It is hypothesized that liver impairment caused by coronavirus disease 2019 (COVID-19) infection might play a central role in severe clinical presentations. Liver injury is closely associated with severe disease and, even with antiviral drugs, have a poor prognosis in COVID-19 patients. In addition to the common hepatobiliary disorders caused by COVID-19, patients with pre-existing liver diseases demand special considerations during the current pandemic. Thus, it is vital that upon clinical presentation, patients with concurrent pre-existing liver disease associated with metabolic dysfunction and COVID-19 be managed properly to prevent liver failure. Careful monitoring and early detection of liver damage through biomarkers after hospitalization for COVID-19 is underscored in all cases, particularly in those with pre-existing metabolic liver injury. The purpose of this study was to determine most recent evidence regarding causality, potential risk factors, and challenges, therapeutic options, and management of COVID-19 infection in vulnerable patients with pre-existing liver injury. This review aims to highlight the current frontier of COVID-19 infection and liver injury and the direction of liver injury in these patients.

show abstract

Acute Liver Failure in a COVID-19 Patient Without any Preexisting Liver Disease

Cited by 21 publications

References 22 publications

Coronavirus Disease-2019 (COVID-19) and the Liver

Coronavirus Disease-2019 (COVID-19) and the Liver

Acute liver injury in the course of COVID-19

COVID-19 infection and liver injury: Clinical features, biomarkers, potential mechanisms, treatment, and management challenges

Contact Info

Product

Resources

About