Atherosclerotic Lesions at Micro CT: Feasibility for Analysis of Coronary Artery Wall in Autopsy Specimens

Abstract

Micro CT is feasible for analysis of the coronary artery wall.

Correlation of Vasa Vasorum Neovascularization and Plaque Progression in Aortas of Apolipoprotein E −/− /Low-Density Lipoprotein −/− Double Knockout Mice

“…11 VV are generally not present in wild-type mice and they do not develop advanced atherosclerotic lesions, but apolipoprotein E (apoE) Ϫ/Ϫ /low-density lipoprotein (LDL) Ϫ/Ϫ double knockout mice develop lesions with considerable structural similarity to human atherosclerosis. 12 The present study was designed to characterize atherosclerotic lesions and the localization and time course of VV neovascularization and adventitial inflammation relative to growing plaques in apoE Ϫ/Ϫ / LDL Ϫ/Ϫ double knockout mice.…”

Digital image correlation–based optical coherence elastography

“…More vascular samples will be measured and correlated with histology to verify the OCE findings. Benefiting from our technique's inherent high resolution, the DIC-based OCE approach has a potential for characterization of atherosclerotic plaques and aneurysms, 35 as well as other lesions.…”

Nano-Computed Tomography: Technique and Applications

“…Plaque hemorrhages were primarily detected in synMCT [15]. In previous studies regarding plaque differentiation of atherosclerotic vascular wall lesions, quantitative statements regarding plaque composition differentiating fibrous, calcified, and lipid-rich plaques could be made in micro-CT studies [16]. The distribution, size, and type of atherosclerotic plaque can also be detected and histologically verified via nano-CT equivalent to micro-CT. Calcifying, fibrotic, and hemorrhagic plaques can be reliably differentiated on the basis of the vasa vasorum density, the X-ray opacity, and the object size [17].…”