Atherosclerosis risk in HIV-infected patients: The influence of hepatitis C virus co-infection

Sosner, P.; Wangermez, Marc; Chagneau‐Derrode, Carine; Moal, G. Le; Silvain, Christine

doi:10.1016/j.atherosclerosis.2012.02.027

Cited by 40 publications

(40 citation statements)

References 14 publications

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“…Similar results were found when HIVinfected persons were excluded from the analysis [13(10-14) vs. 13 (10)(11)(12)(13)(14)(15), p = 0.659]. The FRS was lower in the HIV and HIV/HCV groups compared with the uninfected and HCVmonoinfected groups (Table 1).…”

supporting

confidence: 75%

“…4,5 Data from observational studies suggest that chronic HCV infection is independently associated with increased CVD risk [6][7][8][9][10] and thus HCV coinfection may exacerbate CVD risk in HIV-infected persons. 11,12 The Framingham risk score (FRS) is a widely used global risk score for 10-year coronary heart disease (CHD) risk, validated for use in the general, non-HIV-infected population. 13,14 In HIV-infected persons, it has been increasingly recognized that modified risk prediction tools may be needed for optimal CVD risk assessment.…”

mentioning

confidence: 99%

“…For the primary comparison of FRS in HCV-infected and HCV-uninfected persons, which included HIV-infected persons, the median FRS (in risk points) was not different between the two groups [13 (interquartile range, IQR 10-14) vs. 13 (10)(11)(12)(13)(14), p = 0.192]. Similar results were found when HIVinfected persons were excluded from the analysis [13(10-14) vs. 13 (10)(11)(12)(13)(14)(15), p = 0.659].…”

mentioning

confidence: 99%

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Short Communication: Coronary Heart Disease Risk by Framingham Risk Score in Hepatitis C and HIV/Hepatitis C-Coinfected Persons

Chew

Bhattacharya

McGinnis

et al. 2015

AIDS Research and Human Retroviruses

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We compared the Framingham risk score (FRS) for 10-year coronary heart disease (CHD) risk in age-and race-matched hepatitis C virus (HCV)-infected and HCV-uninfected persons: 114,073 HCV-infected (111,436 HCV-monoinfected and 2,637 HIV/HCV-coinfected) and 122,996 HCV-uninfected (121,380 HIV and HCVuninfected and 1,616 HIV-monoinfected) males without cardiovascular disease, diabetes, or hepatitis B. In unadjusted analyses, FRS was similar between the HCV-infected and HCV-uninfected groups [median (interquartile range, IQR) risk points 13 (10-14) vs. 13 (10-14), p = 0.192]. Cholesterol levels were lower and current smoking more prevalent in the HCV groups (both HCV and HIV/HCV) compared with the uninfected groups ( p < 0.001 for both). Prevalence of non-FRS CHD risk factors, such as substance abuse and chronic kidney disease, in the cohort was high, and differed by HCV and HIV status. Adjusting for age, race/ethnicity, body mass index, chronic kidney disease, drug and alcohol use, and HIV status, HCV infection was associated with minimally lower FRS (b = -0.095 risk points, p < 0.001), suggesting a small but significant difference in 10-year CHD risk estimation in HCV-infected as compared to HCV-uninfected persons when measuring risk by FRS. Given the complex relationship between HCV, HIV, and CHD risk factors, some of which are not captured by the FRS, the FRS may underestimate CHD risk in HCV-monoinfected and HIV/HCV-coinfected persons. HCV-and HIV/HCV-specific risk scores may be needed to optimize CHD risk stratification.

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supporting

confidence: 75%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Short Communication: Coronary Heart Disease Risk by Framingham Risk Score in Hepatitis C and HIV/Hepatitis C-Coinfected Persons

Chew

Bhattacharya

McGinnis

et al. 2015

AIDS Research and Human Retroviruses

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“…Our study shows that CH-C is independently associated with three important metabolic conditions: IR, DM and hypertension. Although the association of HCV with IR and DM has been previously reported, [18][19][20][21][22][23][24] the association of HCV with hypertension is a novel finding. 3,4 In fact, in one of our previous population-based studies, 21 we reported that the association of HCV with IR and DM might have been attenuated in the last decade by the epidemics of obesity.…”

Section: Discussionmentioning

confidence: 83%

“…This association was present after controlling for important confounders associated with both metabolic conditions as well as cardiovascular diseases, namely, age, smoking and obesity. Although previous studies have suggested an increased risk of carotid atherosclerosis in patients with CH-C, [22][23][24][25] the most important association between HCV and coronary artery disease (CAD) has been reported in the HIV/HCV co-infected cohort. 26 In fact, another study reported that the risk of acute myocardial infarction in patients with CH-C was not increased.…”

Section: Discussionmentioning

confidence: 99%

Associations of chronic hepatitis C with metabolic and cardiac outcomes

Younossi

Stepanova

Nader

et al. 2013

Aliment Pharmacol Ther

144

133

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Influenza virus aggravates the ox-LDL-induced apoptosis of human endothelial cells via promoting p53 signaling

et al. 2015

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Oxidized low-density lipoprotein (ox-LDL) is well recognized to play a key role in the development of atherosclerosis. And influenza virus infection has been also recognized to promote the atherosclerosis onset and progressing. However, little is known about the mechanism into it. In present study, we investigated the infection of A/Porto Rico/8/1934 (H1N1) (PR8) influenza virus in human endothelial Eahy926 cells, and determined the induction of apoptosis by the virus infection in the cell. Then we investigated the apoptosis induced by ox-LDL in Eahy926 cells, determined the influence of influenza virus infection on the ox-LDL-induced apoptosis in Eahy926 cells. Results demonstrated that PR8 virus infected human endothelial Eahy926 cells, forming plaques and replicated efficiently in the cell. And the virus infection promoted apoptosis in the cell, upregulated cytchrome c release, activated caspase 3. And what's more, we found that combined PR8 virus infection and ox-LDL treatment promoted higher level of apoptosis and higher level of the activation of apoptosis-associated molecules. Further examination indicated that the p53 signaling was more significantly promoted by both treatments. Therefore, present study confirmed that influenza virus aggravated the ox-LDL-induced apoptosis of human endothelial Eahy926 cells via promoting p53 signaling.

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Atherosclerosis risk in HIV-infected patients: The influence of hepatitis C virus co-infection

Cited by 40 publications

References 14 publications

Short Communication: Coronary Heart Disease Risk by Framingham Risk Score in Hepatitis C and HIV/Hepatitis C-Coinfected Persons

Short Communication: Coronary Heart Disease Risk by Framingham Risk Score in Hepatitis C and HIV/Hepatitis C-Coinfected Persons

Associations of chronic hepatitis C with metabolic and cardiac outcomes

Influenza virus aggravates the ox-LDL-induced apoptosis of human endothelial cells via promoting p53 signaling

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