Atherosclerosis regression study in rabbits upon olive pomace polar lipid extract administration

Tsantila, Nektaria; Karantonis, Haralabos C.; Περρέα, Δέσποινα; Theocharis, Stamatios; Iliopoulos, Dimitrios; Iatrou, Christos; Antonopoulou, Smaragdi; Demopoulos, Constantinos A.

doi:10.1016/j.numecd.2009.06.008

Cited by 41 publications

(27 citation statements)

References 31 publications

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“…Lipid microconstituents of specific foods animal-origin, i.e., cheese (Tsorotioti et al 2014) and eggs (Nasopoulou et al 2013), that constitute important ingredients of the Mediterranean diet, have been found to exert in vitro important biological activities by inhibiting PAF actions. These lipid microconstituents could inhibit the onset of the atherosclerosis and the development of CVDs, as several in vivo studies have shown (Karantonis et al 2006;Tsantila et al 2007;Nasopoulou et al 2010;Tsantila et al 2010). …”

Section: Biological Activity Of Tl Tpl Of All Three Samplesmentioning

confidence: 99%

Evaluation of the in vitro anti-atherogenic activities of goat milk and goat dairy products

Poutzalis

Anastasiadou

Nasopoulou

et al. 2015

Dairy Sci. & Technol.

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Given that goat milk and dairy products should be consumed daily according to suggestions based on Mediterranean diet, the current study evaluates the antiatherogenic properties of goat milk and goat dairy products (yogurt and white cheese). Total lipids (TLs) of all three samples were extracted by the method of Bligh and Dyer and further separated into total polar lipids (TPLs) and total neutral lipids (TNLs) by counter current distribution. The fatty acid profiles of TPL and TNL of all three samples were determined by gas chromatography analysis. TL and TPL were tested to determine whether they induce platelet aggregation or inhibit platelet aggregation induced by the platelet-activating factor (PAF). The most active lipids were found in goat white cheese (i.e., since they showed lower IC 50 values in both TL and TPL samples than corresponding fractions of goat milk and goat yogurt), so the TPL of goat white cheese were further separated by preparative thin-layer chromatography (TLC). The obtained polar lipid fractions after TLC separation were also tested for their biological activity. All the samples' lipids, and especially the polar ones, were found to exhibit strong anti-atherogenic activities. This fact highlights the nutritional value of goat dairy products in terms of cardioprotection, as PAF is a crucial inflammatory mediator that is implicated in the mechanism of atherogenesis.

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Section: Biological Activity Of Tl Tpl Of All Three Samplesmentioning

confidence: 99%

Evaluation of the in vitro anti-atherogenic activities of goat milk and goat dairy products

Poutzalis

Anastasiadou

Nasopoulou

et al. 2015

Dairy Sci. & Technol.

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“…23 Unsaturated fatty acids inhibit human platelet phospholipase A2 activity, 24 thus hindering the progression of atherogenesis. 25 This property is directly related to the prevention of CVD.…”

Section: Abcmentioning

confidence: 99%

“…12 Given the involvement of platelets in atherogenesis, from early stages of this process, together with other cardioprotective functions of bioactive compounds in tomatoes, and reduction of low density lipoprotein and decreased blood pressure. 25 Future analysis will be necessary to study the effect of the extract/fractions of tomato/pasta/pomace on other aspects of the atherothrombotic process, such as platelet function (adhesion, spreading, secretion, and platelet aggregation), endothelial function, and platelet-leukocyte function among others. Inhibition of platelet function could be beneficial in preventing thrombosis and proinflammatory events associated with platelet activation.…”

Section: Abcmentioning

confidence: 99%

Effect of Tomato Industrial Processing (Different Hybrids, Paste, and Pomace) on Inhibition of Platelet Function In Vitro, Ex Vivo, and In Vivo

Rodríguez-Azúa¹,

Treuer²,

Moore‐Carrasco

et al. 2014

Journal of Medicinal Food

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Cardiovascular disease (CVD) is the leading cause of death worldwide. Healthy eating is among its safeguards, especially the daily intake of fruits and vegetables. In this context it has been shown that tomato (Solanum lycopersicum) presents antiplatelet activity. In the present study, we evaluated in vitro antiplatelet activity of fresh hybrid tomato process (nine hybrids: Apt 410, H 9888, Bos 8066, Sun 6366, AB3, HMX 7883, H 9665, H 7709, and H 9997), paste and its byproduct of industrial processes (pomace). We assessed antiplatelet activity ex vivo and bleeding time in rats that ingested 0.1 and 1.0 g/kg of pomace each day. In studies in vitro, no significant differences in antiplatelet activity was observed in fresh tomato hybrids. Furthermore, the agro-industrial process did not affect the antiplatelet activity of paste and pomace. Likewise, pomace intake of 1.0 g/kg per day prolonged bleeding time and reduced ex vivo platelet aggregation in rats. The data obtained indicate that tomato has one or more compounds that caused antiplatelet activity. Regular consumption of tomato and its industrial derivatives could be part of a CVD prevention regimen.

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“…The beneficial effect of omega-3 PUFA on cardiovascular disease was previously attributed to reducing plasma cholesterol and triacylglycerol levels (Shearer, Savinova, & Harris, 2012) or by inhibiting some of the stages of atherogenesis (Mori, Beilin, Burke, Morris, & Ritchie, 1997;Sneddon, McLeod, Wahle, & Arthur, 2006;Weber, Aepfelbacher, Lux, Zimmer, & Weber, 1991). To explain the lack of association between omega-3 PUFA intake and cardiovascular disease observed by (Rizos et al, 2012) it was postulated that the development of atherosclerotic lesions was not influenced by the levels of cholesterol and triacylglycerol but by the actions of polar lipids that acted as platelet activating factor inhibitors (Karantonis, Antonopoulou, & Perrea, 2006;Nasopoulou, Karantonis, Perrea, Theocharis, & Iliopoulos, 2010;Tsantila et al, 2007;Tsantila et al, 2010). These polar lipids may therefore be responsible to inhibit the onset of atherosclerosis and the development of cardiovascular disease (Nasopoulou et al, 2014).…”

Section: Polar Fatty Acidsmentioning

confidence: 99%

Socio-economic dynamics and innovative technologies affecting health-related lipid content in diets: Implications on global food and nutrition security

Nantapo

Muchenje

Nkukwana

et al. 2015

Food Research International

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Atherosclerosis regression study in rabbits upon olive pomace polar lipid extract administration

Cited by 41 publications

References 31 publications

Evaluation of the in vitro anti-atherogenic activities of goat milk and goat dairy products

Evaluation of the in vitro anti-atherogenic activities of goat milk and goat dairy products

Effect of Tomato Industrial Processing (Different Hybrids, Paste, and Pomace) on Inhibition of Platelet Function In Vitro, Ex Vivo, and In Vivo

Socio-economic dynamics and innovative technologies affecting health-related lipid content in diets: Implications on global food and nutrition security

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