1993
DOI: 10.1016/0140-6736(93)92413-n
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Atherosclerosis in Alaska Natives and non-natives

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Cited by 135 publications
(84 citation statements)
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“…5% predicted incidence based on the high-fat diet that they consumed) was thought to be in part attributable to the dietary fat composition, and it was suggested that the anti-thrombotic effect of the marine LC PUFA may be responsible for the cardioprotection. Subsequent studies among other populations with a high intake of LC n-3 PUFA, such as Alaskans and the Japanese, have also observed a low incidence of CVD (Hamazaki et al 1988;Newman et al 1993). From this starting point many subsequent studies have provided evidence that more modest EPA and DHA intakes have cardio-protective properties, although epidemiological studies in Western populations have at times demonstrated mixed outcomes.…”
Section: Studies Examining the Health Benefits Of Oily Fish Intakementioning
confidence: 99%
“…5% predicted incidence based on the high-fat diet that they consumed) was thought to be in part attributable to the dietary fat composition, and it was suggested that the anti-thrombotic effect of the marine LC PUFA may be responsible for the cardioprotection. Subsequent studies among other populations with a high intake of LC n-3 PUFA, such as Alaskans and the Japanese, have also observed a low incidence of CVD (Hamazaki et al 1988;Newman et al 1993). From this starting point many subsequent studies have provided evidence that more modest EPA and DHA intakes have cardio-protective properties, although epidemiological studies in Western populations have at times demonstrated mixed outcomes.…”
Section: Studies Examining the Health Benefits Of Oily Fish Intakementioning
confidence: 99%
“…The low incidence has been con®rmed by autopsies (Lederman et al, 1962;Arthaud, 1970;Newman et al, 1993Newman et al, , 1995 and by studies of death certi®cates (Bjerregaard & Dyerberg, 1988;Middaugh, 1990). Ensuing studies have found several associations between the intake of n-3 fatty acids of marine origin and risk factors for cardiovascular disease as well as cardiovascular end-points.…”
Section: Introductionmentioning
confidence: 99%
“…Low mortality rate from CHD in epidemiological studies has been reported in populations with high intake of fish, such as Alaskan Natives (2) , Greenland Eskimos (3) and Japanese residing in fishing villages (4) . However, not all prospective cohort studies have found an inverse association between fish consumption and fatal CHD (5)(6)(7) .…”
mentioning
confidence: 99%