Atherosclerosis: An Extra Articular Manifestation of Rheumatoid Arthritis

Aziz, Maria; Ks, Yadav

doi:10.21767/2386-5180.1000132

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Endothelial dysfunction is the first step in atherogenesis and its development in RA is associated with multiple factors: systemic inflammation, proinflammatory cytokines (TNF-α, IL-6, IL-1, IFN-γ, and IL-17), oxidative stress, disbalance of certain hormones (leptin, resistin, and adiponectin), increased expression of adhesion molecules, altered endothelial progenitor cell function, immune dysregulation, genetic predisposition, as well as traditional factors such as diabetes mellitus, arterial hypertension, and high body mass index [25]. Systemic inflammation and immune dysregulation seem to impair production of nitric oxide (NO), a molecule which has an important protective role in arteries [26].…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Pathogenesis of Extraarticular Manifestations in Rheumatoid Arthritis—A Comprehensive Review

et al. 2023

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Rheumatoid arthritis (RA) is among the most prevalent and debilitating autoimmune inflammatory chronic diseases. Although it is primarily characterized by destructive peripheral arthritis, it is a systemic disease, and RA-related extraarticular manifestations (EAMs) can affect almost every organ, exhibit a multitude of clinical presentations, and can even be asymptomatic. Importantly, EAMs largely contribute to the quality of life and mortality of RA patients, particularly substantially increased risk of cardiovascular disease (CVD) which is the leading cause of death in RA patients. In spite of known risk factors related to EAM development, a more in-depth understanding of its pathophysiology is lacking. Improved knowledge of EAMs and their comparison to the pathogenesis of arthritis in RA could lead to a better understanding of RA inflammation overall and its initial phases. Taking into account that RA is a disorder that has many faces and that each person experiences it and responds to treatments differently, gaining a better understanding of the connections between the joint and extra-joint manifestations could help to create new treatments and improve the overall approach to the patient.

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Section: Endothelial Dysfunctionmentioning

confidence: 99%

Pathogenesis of Extraarticular Manifestations in Rheumatoid Arthritis—A Comprehensive Review

et al. 2023

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“…Together with immune dysregulation, it contributes to endothelial dysfunction and atheroma plaque development. The cardiovascular risk begins to be evident from the early stages of RA, making the cardiovascular investigation necessary even from the first medical visit [26].…”

Section: Inflammationmentioning

confidence: 99%

Vascular Involvement in Rheumatoid Arthritis

Caraba¹,

Iurciuc²,

Iurciuc³

2020

Rheumatoid Arthritis - Other Perspectives Towards a Better Practice

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“…These cardinal features collectively define the complex landscape of RA. Moreover, RA's impact is not confined solely to joint involvement, encompassing diverse systemic manifestations such as dermatological symptoms, fever, muscle wasting, and weakness [2][3][4][5]. Rheumatoid arthritis exhibits a higher prevalence among women, particularly in their 40s [6].…”

Section: Introductionmentioning

confidence: 99%

Pan-Immune-Inflammation Index as a Biomarker for Rheumatoid Arthritis Progression and Diagnosis

Tutan,

Doğan

2023

Cureus

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Introduction Rheumatoid arthritis (RA) is a chronic autoimmune condition that causes systemic inflammation and affects multiple joints. It is characterized by joint warmth, swelling, pain, and the formation of invasive synovial tissue known as pannus, which contributes to cartilage and bone degradation. Pan-immune-inflammation value (PIV), a marker derived from complete blood count parameters, has shown promise in predicting prognosis in various cancer types and pediatric conditions associated with immune abnormalities. This study aims to explore the relationship between RA, characterized by chronic inflammation and immune system involvement, and PIV, potentially shedding light on novel insights into RA's clinical implications. Methods One hundred four participants, including 64 RA patients (both newly diagnosed and established cases) and 40 healthy controls, were included in the study. Exclusion criteria for RA patients included acute infection, cancer, diabetes, or chronic illness, while control participants were excluded for inflammatory disorders, active infection, diabetes, or malignancy. We assessed disease severity using Disease Activity Score 28 (DAS 28) and obtained complete blood count values, including neutrophil, lymphocyte, platelet, monocyte, and red cell distribution width. C-reactive peptide (CRP) and erythrocyte sedimentation rate were also added. Statistical analyses included correlation assessments, t-tests, Mann-Whitney U tests, and multivariate linear regression. A multiclass receiver operating characteristic analysis determined optimal PIV cut-off values for distinguishing control, remission, and active RA groups, with sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy, and odds ratios calculated. Results This study comprised a cohort of 104 participants, with a median age of 43.5±17.5. The Remission group was significantly younger than the Control group (p=0.006) but not compared to the Active RA group (p=0.393). CRP levels were significantly higher in the Active RA group (p<0.001). Neutrophil counts were highest in the Active RA group (p<0.001), as were monocyte counts. Lymphocyte counts were significantly lower in the Active RA group (p<0.001). There were no significant differences in sedimentation rate, hemoglobin, platelet count, and mean platelet volume. PIV was significantly elevated in the Active RA group (p<0.001) and higher in the Remission group than in the Control group (p=0.001). A PIV value of 353.48 exhibited 71.4% sensitivity, 86.2% specificity, 86.2% PPV, 71.4% NPV, and 78.13% test accuracy for distinguishing active rheumatoid arthritis (p<0.001). A PIV value exceeding 353.48 substantially increased the likelihood of a patient belonging to the active rheumatoid arthritis group, with a 14.62-fold higher probability. Furthermore, the study explored the relationship between clinical and laboratory variables and disease activity in RA patients, finding significant diffe...

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Atherosclerosis: An Extra Articular Manifestation of Rheumatoid Arthritis

Cited by 4 publications

References 25 publications

Pathogenesis of Extraarticular Manifestations in Rheumatoid Arthritis—A Comprehensive Review

Pathogenesis of Extraarticular Manifestations in Rheumatoid Arthritis—A Comprehensive Review

Vascular Involvement in Rheumatoid Arthritis

Pan-Immune-Inflammation Index as a Biomarker for Rheumatoid Arthritis Progression and Diagnosis

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