Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women

Bendžala, Matej; Sabaka, Peter; Čaprnda, Martin; Komornikova, Andrea; Bisahova, Maria; Baneszova, Ruth; Petrovič, Daniel; Prosecký, Robert; Rodrigo, Luı́s; Kružliak, Peter; Dukát, Andrej

doi:10.1007/s00508-017-1264-1

Cited by 34 publications

(31 citation statements)

References 31 publications

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“…As reported by Ravnskov et al, 7 there are many observations and experiments contradicting that high TC or LDL‐C causes atherosclerosis and CVD, and several recent observations have supported their view. For instance, six recent follow‐up studies including almost 700 000 individuals of all ages from various countries have shown that neither TC nor LDL‐C is a risk factor of mortality, neither among statin‐treated patients nor among untreated individuals 21‐25 . In fact, as shown by our results as well, low values are associated with increased total mortality.…”

Section: Discussionsupporting

confidence: 55%

Baseline plasma lipid levels in patients with acute coronary syndrome: Association with 20‐year mortality. The ABC‐5a* Study on Heart Disease

Berton

Cordiano²,

Mahmoud

et al. 2020

Int J Clin Pract

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Background The relationship between baseline plasma lipid levels during acute coronary syndrome and the outcome has clinical relevance. Methods To evaluate their long‐term prognostic value, we examined 589 patients admitted with acute coronary syndrome at three hospitals. Baseline plasma lipids were assessed on days 1 and 7. Patients were followed for 20 years or until death. Results Virtually, all patients completed follow‐up; 437 (74%) had died: 24% from coronary artery disease/heart failure (CAD/HF), 21% sudden cardiac death (SCD), 16% from other cardiovascular causes and 39% had non‐cardiac death. The incidence rate (IR) of all‐cause mortality was not different among patients with baseline plasma lipids less or greater than the median value. The IR of CAD/HF mortality was not significantly higher among patients with greater than median low‐density lipoprotein (LDL) cholesterol and triglyceride (TG) levels. The IR of non‐cardiac death tended to be lower among patients with greater than median total cholesterol (TC) and LDL levels. Using three levels of adjusted Cox survival models, baseline plasma lipids had no consistent independent or inverse association with all‐cause mortality, even after excluding patients who received statins. Competitive risk survival models for each cause of death revealed that the only hazard of non‐cardiac death was consistently higher among patients with less than or equal to median TC and LDL levels. Conclusion In the present prospective long‐term study, after acute coronary syndrome, baseline plasma lipid levels seem not to be associated with long‐term global mortality. Only an independent inverse association between TC and LDL and non‐cardiac death has been observed.

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Section: Discussionsupporting

confidence: 55%

Baseline plasma lipid levels in patients with acute coronary syndrome: Association with 20‐year mortality. The ABC‐5a* Study on Heart Disease

Berton

Cordiano²,

Mahmoud

et al. 2020

Int J Clin Pract

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“…This lipoprotein subfraction named AIP is well-known for its strong association with the development of CAD, all-cause mortality, and it also predicts emergency cardiovascular events [ 6 – 9 , 24 – 27 ]. Dobiášová et al [ 28 ] further proved that AIP is strongly associated with atherosclerosis and its complications by establishing an association between the AIP and coronary angiographic findings in patients with CAD.…”

Section: Discussionmentioning

confidence: 99%

Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women

et al. 2018

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BackgroundDyslipidemia is one of the most important factors for coronary artery disease (CAD). Atherogenic index of plasma (AIP) is a novel indicator involved in dyslipidemia. However, the relation between AIP and CAD in postmenopausal women remains unclear. We hypotheses that AIP is a strong predictive indicator of CAD in postmenopausal women.MethodsA propensity score matching case–control study including 348 postmenopausal CAD cases and 348 controls was conducted in the present study.ResultsCompared with controls, CAD patients had higher levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (APOB), but lower high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 (APOA-1). The values of nontraditional lipid profiles, including non-HDL-C, TC/HDL-C, LDL-C/HDL-C, non-HDL-C/HDL-C (atherogenic index, AI), TC∗TG∗LDL/HDL-C (lipoprotein combine index, LCI), log(TG/HDL-C) (atherogenic index of plasma, AIP) and APOB/APOA-1 were all significantly higher in the CAD patients. The results of Pearson correlation analyses showed AIP was positively and significantly correlated with TC (r = 0.092, P < 0.001), TG (r = 0.775, P = 0.015), APOB (r = 0.140, P < 0.001), non-HDL-C (r = 0.295, P < 0.001), TC/HDL-C (r = 0.626, P < 0.001), LDL-C/HDL-C (r = 0.469, P < 0.001), AI (r = 0.626, P < 0.001), LCI (r = 0.665, P < 0.001), APOB/APOA-1(r = 0.290, P < 0.001) and was negatively correlated with APOA-1 (r = − 0.278, P < 0.001) and HDL-C (r = − 0.665, P < 0.001). In the multivariate logistic regression analysis, AIP was an independent predictor of CAD. After adjusting for the traditional clinical prognostic factors including diabetes and hypertension, we found AIP could be an independent risk factor for CAD (odds ratio [OR], 3.290; 95% confidence interval [CI], 1.842–5.877, P < 0.001). After adjusting for multiple clinical factors include diabetes, hypertension, smoking, heart ratio, fasting blood glucose, we found AIP also could a powerful risk factor, OR = 3.619, 95%CI (2.003–6.538), P < 0.001.ConclusionThe present study indicated that AIP might be a strong marker for predicting the risk of CAD in postmenopausal women.

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“…The use of AIP as an atherogenic index is a strong predictor of myocardial infarction and atherosclerosis and the study ndings supported other studies which indicated that high AIP is directly associated with older age, [20][21] and could be used as a stand-alone index for cardiac risk estimation. [17][18][19][20][21] Furthermore, studies indicated that serum albumin is inversely related to in ammatory processes, [13] and hypoalbuminemia is strongly correlated with all-cause mortality and cardiovascular mortality. [22] The current study revealed that a signi cant number of Saudi men (41%) and women (54%) had hypoalbuminemia.…”

Section: Discussionmentioning

confidence: 99%

“…[16] Moreover, the Atherogenic Index of Plasma (AIP) which is the logarithm of triglycerides to HDL-C ratio, is shown to be a good predictor of the risk of all-cause deaths amongst the older adults and a useful non-traditional indicator for CVD risk. [17][18] The determination of selected CVD risk factors helps in identifying those older adults who are at increased risk of morbidity and mortality, hence developing appropriate programs in the country. The current study aimed to determine the body composition, selected biochemical markers and CVD risk amongst free-living older Saudi men and women.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Markers, Body Composition and Risk of Cardiovascular Disease Amongst Geriatric Population in Al Madinah Al Munawarah: A Risk Assessment Study

Mohammedsaeed

Shikieri

2020

Preprint

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Objective: to assess selected biochemical markers and body composition and their association with CVD risk amongst older adults in Al Madinah Al Munawarah, Saudi Arabia.Results: Older adults had high glycated hemoglobin percent (women 7∙90±2∙95; men 8∙4±1∙64, P <0∙001), C-reactive protein (women 17∙1±5∙92; men 36∙1±7∙8, P <0∙003) and Atherogenic Index of Plasma (AIP; women 0∙21±0∙18; men 0∙22±0∙21, P <0∙04) with higher values amongst men compared to their counterparts. In addition, they suffered from hypoalbuminemia and low hemoglobin levels. Older adults were malnourished, either underweight (16%) or overweight and obese (35%). Based on their AIP, most of the participants had intermediate to high CVD risk. Multiple Linear Regression model with age as the dependent variable showed that the risk of CVD increased with higher BMI (women only: Odd ratio 6.99, 95% CI: 0.96-5.03, P <0.001), elevated triglycerides (women: Odd ratio 7.47, 95% CI: 0.16-3.17; men: Odd ratio: 6.55, 95% CI: 0.23-3.26, P <0.001), high C-reactive protein (Odd ratio 8.99, 95% CI: 0.99-6.00, P = 0.003; men: Odd ratio 4.00, 95% CI: 0.99-3.01, P < 0.002) and high AIP (women: Odd ratio 14.6, 95% CI: 0.0.56-16.18, P = 0.002; men: Odd ratio 7.35, 95% CI: 0.35-20.29, P < 0.001).

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Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women

Abstract: The AIP is positively associated with the risk of all-cause death in elderly women with arterial hypertension independent of age, smoking habits, statin therapy and comorbidities.

Cited by 34 publications

References 31 publications

Baseline plasma lipid levels in patients with acute coronary syndrome: Association with 20‐year mortality. The ABC‐5a* Study on Heart Disease

Baseline plasma lipid levels in patients with acute coronary syndrome: Association with 20‐year mortality. The ABC‐5a* Study on Heart Disease

Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women

Biochemical Markers, Body Composition and Risk of Cardiovascular Disease Amongst Geriatric Population in Al Madinah Al Munawarah: A Risk Assessment Study

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