Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever

Acay, Akif; Ulu, Memnune Sena; Ahsen, Ahmet; Özkeçeci, Gülay; Demir, Kasım; Özuğuz, Ufuk; Yüksel, Şeref; Acartürk, Gürsel

doi:10.1016/j.medici.2014.11.009

Cited by 41 publications

(35 citation statements)

References 18 publications

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“…The difference between two groups was not statistically significant in terms of GSTT1 and GSTM1 gene polymorphisms (p>0.05). GSTP1 Ile105Val polymorphism frequencies were 55% (n=33), 36 Table 4. The possible association between combined genotypes and CIMT, and triple genotype analysis was not investigated because of the possibility of low statistical power.…”

Section: Resultsmentioning

confidence: 99%

“…In the studies which showed higher CIMT value in FMF patients, Ugurlu et al 41 have found statistically significantly lower HDL and LDL levels and Bilginer et al 34 found statistically insignificant LDL and significantly higher HDL in FMF patients compared to healthy controls. Acay et al 36 have detected higher LDL level in FMF patients but the difference between patients and controls was not statistically significant. In their study, HDL cholesterol was statistically significantly lower in FMF patients.…”

mentioning

confidence: 88%

“…32,33 Relationship between atherogenesis and low-grade inflammatory conditions such as ankylosing spondylitis and FMF has been relatively recently suggested and studies about this relationship build up over time. [34][35][36] However, studies investigating carotid atherosclerosis in FMF found less aggressive course of atherogenesis than atherogenesis in highgrade inflammatory disorders. 37 CIMT represents an indicator of atherosclerosis and increased CIMT has been accepted to be associated with severity of coronary atherosclerosis.…”

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confidence: 99%

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Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

Gürbüz

Bağcı²,

Hüzmelí

et al. 2016

Arch Rheumatol

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Objectives: This study aims to evaluate the carotid intima-media thickness (CIMT) in patients diagnosed with familial Mediterranean fever (FMF) and investigate whether there is a relationship between glutathione-S-transferase (GST) gene polymorphisms and CIMT. Patients and methods: Sixty FMF patients (17 males, 43 females; mean age: 31.43±11.36 years; range 18 to 45 years) and 60 healthy controls (22 males, 38 females; mean age: 29.8±5.82 years; range 18 to 40 years) were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism methods were carried out to assess GST polymorphisms. CIMT was measured by carotid ultrasonography. Biochemical parameters were also evaluated using biochemical methods. Results: Right and left CIMT of FMF patients were statistically significantly higher than that of control group (CIMT right p=0.001 and CIMT left: p=0.033). There was no significant association in terms of GST polymorphisms between FMF and control groups. No significant association was observed between GST polymorphisms and CIMT. Low density lipoprotein, erythrocyte sedimentation rate, and fibrinogen levels were significantly higher in the patient group (p<0.05). The difference between groups was not significant in terms of other biochemical parameters (p>0.05). Conclusion: Although no significant association was observed between GST polymorphisms and CIMT in FMF patients and controls, CIMT was statistically significantly higher in FMF patients compared to controls.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 88%

mentioning

confidence: 99%

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Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

Gürbüz

Bağcı²,

Hüzmelí

et al. 2016

Arch Rheumatol

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“…Acay et al detected significantly higher TG/HDL-C ratio in patients with FMF versus healthy population [35]. However, the correlation between TG/HDL-C ratio and endothelial dysfunction in CID cases has not been fully clarified.…”

Section: Discussionmentioning

confidence: 99%

Is Triglyseride/ HDL Ratio A Reliable Screening Test for Assesment of Atherosclerotic Risk in Patients With Chronic Inflammatory Diseases?

Keleş

Aksu

Açıksarı

et al. 2016

North Clin Istanbul

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OBJECTIVE:The term chronic inflammatory disease (CID) refers to a category of inflammatory diseases that includes Ankylosing spondylitis (AS) and familial Mediterranean fever (FMF). The incidence of adverse cardiovascular events is greater among patients with CID, though they may not have conventional atherosclerotic risk factors. Endothelial dysfunction is one of the underlying fundamental mechanisms that trigger development of atherosclerotic alterations in arteries, and flow-mediated dilatation (FMD) is a noninvasive method to determine endothelial dysfunction. Recent studies have shown a relationship between high triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio and coronary atherosclerosis. Many studies have demonstrated that patients with CID have lower FMD values compared to healthy population, indicating endothelial dysfunction. However TG/HDL ratio and its relationship to FMD in patients with CID has not been investigated. The present study investigated whether TG/HDL ratio in CID patients differs from that of healthy population, and its relationship to FMD in patients with CID.METHODS:A total of 58 patients with CID and a group of 58 healthy volunteer individuals were enrolled in the study. FMD measurements were taken with high resolution ultrasound (US), and TG/HDL ratios were calculated.RESULTS:Patients with CID had significantly higher TG/HDL-C ratio (2.5 [2.2–2.8] vs 2.3 [2.1–2.5]; p=0.03) and lower FMD values (5.2 [4.2–6.3] vs 6.7 [6.3–9.7]; p<0.001), compared to healthy group, and a negative correlation was found between FMD levels and TG/HDL ratio of the study population.CONCLUSION:Higher TG/HDL ratio and lower FMD values found in CID patients may reflect increased atherosclerotic risk.

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“…Particularly fascinating is the impaired autophagic clearance of inflammasomes associated with common mutations in the MEFV gene found in patients with Familial Mediterranean Fever (58). This relatively common genetic disorder results in IL-1β hypersecretion (61) and increased atherogenesis (62, 63). We believe these studies collectively constitute sufficient evidence to distinguish autophagic clearance of inflammasomes from “bulk” autophagy and propose the term “inflammasomophagy” to refer to this selective process (Figure 3).…”

Section: Autophagic Degradation Of Inflammasomes By “Inflammasomophagy”mentioning

confidence: 99%

Target acquired: Selective autophagy in cardiometabolic disease

et al. 2017

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The accumulation of damaged or excess proteins and organelles is a defining feature of metabolic disease in nearly every tissue. Thus, a central challenge in maintaining metabolic homeostasis is the identification, sequestration, and degradation of these cellular components including protein aggregates, mitochondria, peroxisomes, inflammasomes, and lipid droplets. A primary route through which this challenge is met is selective autophagy, the targeting of specific cellular cargo for autophagic compartmentalization and lysosomal degradation. In addition to its roles in degradation, selective autophagy is emerging as an integral component of inflammatory and metabolic signaling cascades. In this review, we focus on emerging evidence and key questions about the role of selective autophagy in the cell biology and pathophysiology of metabolic diseases such as obesity, diabetes, atherosclerosis, and steatohepatitis. Essential players in these processes are the selective autophagy receptors, defined broadly as adapter proteins that both recognize cargo and target it to the autophagosome. Additional domains within these receptors may allow integration of information about autophagic flux with critical regulators of cellular metabolism and inflammation. Details regarding the precise receptors involved, such as p62 and NBR1, and their predominant interacting partners are just beginning to be defined. Overall, we anticipate the continued study of selective autophagy will prove informative in understanding the pathogenesis of metabolic diseases and to provide previously unrecognized therapeutic targets.

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Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever

Cited by 41 publications

References 18 publications

Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

Is Triglyseride/ HDL Ratio A Reliable Screening Test for Assesment of Atherosclerotic Risk in Patients With Chronic Inflammatory Diseases?

Target acquired: Selective autophagy in cardiometabolic disease

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