2017
DOI: 10.1126/scisignal.aag2298
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Abstract: The accumulation of damaged or excess proteins and organelles is a defining feature of metabolic disease in nearly every tissue. Thus, a central challenge in maintaining metabolic homeostasis is the identification, sequestration, and degradation of these cellular components including protein aggregates, mitochondria, peroxisomes, inflammasomes, and lipid droplets. A primary route through which this challenge is met is selective autophagy, the targeting of specific cellular cargo for autophagic compartmentaliza… Show more

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Cited by 56 publications
(44 citation statements)
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References 258 publications
(295 reference statements)
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“…Lipophagy, which is reviewed by Evans et al . (63) in the same issue, is a selective autophagic degradation of lipids. Although it was first demonstrated in hepatocytes, where pharmacological and genetic inhibition of autophagy in cultured hepatocytes lead to increased triglyceride accumulation (64), lipophagy has also been detected in hepatic stellate cells, neurons, and brown adipocytes (6569).…”
Section: Physiological Regulation Of Autophagy In Adipose Tissuesmentioning
confidence: 97%
“…Lipophagy, which is reviewed by Evans et al . (63) in the same issue, is a selective autophagic degradation of lipids. Although it was first demonstrated in hepatocytes, where pharmacological and genetic inhibition of autophagy in cultured hepatocytes lead to increased triglyceride accumulation (64), lipophagy has also been detected in hepatic stellate cells, neurons, and brown adipocytes (6569).…”
Section: Physiological Regulation Of Autophagy In Adipose Tissuesmentioning
confidence: 97%
“…The canonical molecular basis for selective macroautophagy features linking of tagged cargo to the autophagosome via adapter proteins [15] Thus, it is of great interest to determine how lipid droplets might be tagged to recruit autophagosomes, which proteins are relevant adapters, and more broadly, how this physical interaction is otherwise initiated and regulated.…”
Section: Molecular Machinery Of Lipophagy: Identification and Inductionmentioning
confidence: 99%
“…During selective autophagy, it serves as an adapter between polyubiquinated cargo and the autophagosome coat protein light chain 3 (LC3) [15]. One possible mechanism for lipid droplet ubiquitination is via ancient ubiquitous protein 1, a highly expressed lipid droplet protein able to recruit the ubiquitin conjugating enzyme E2 G2 [17], though a clear link to subsequent autophagic degradation is uncertain.…”
Section: Molecular Machinery Of Lipophagy: Identification and Inductionmentioning
confidence: 99%
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“…Importantly, SQSTM1 is a known marker for autophagic flux activity. In pathological settings like aging and disease, SQSTM1 accumulates as result of failed autophagic clearance (Moscat et al, 2016 ; Evans et al, 2017 ). Stimulation of autophagy flux causes degradation of SQSTM1 (Sarkar et al, 2014 ).…”
Section: Introductionmentioning
confidence: 99%