ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

Yang, Yanyan; Yang, Woo Seok; Yu, Tao; Sung, Gi‐Ho; Park, Kye Won; Yoon, Keejung; Son, Young–Jin; Hwang, Hyunseung; Kwak, Youn‐Sig; Lee, Chang-Muk; Rhee, Man Hee; Kim, Jong-Hoon; Cho, Jae Youl

doi:10.1016/j.jep.2014.04.008

Cited by 50 publications

(42 citation statements)

References 68 publications

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“…The root of Korean ginseng ( Panax ginseng Meyer) has been used for 20 centuries in Korea, China, and Japan, and its beneficial activities, including antioxidative, anti-inflammatory, antidiabetic, antiobesity, and anticancer effects, have been widely demonstrated [1], [2]. Recent systemic studies have improved our understanding of the pharmacologic mechanisms and active components in P. ginseng roots.…”

Section: Introductionmentioning

confidence: 99%

Anticancer effect of joboksansam, Korean wild ginseng germinated from bird feces

Park

Kang²,

Park

et al. 2016

Journal of Ginseng Research

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BackgroundJoboksansam, Korean bird wild ginseng, is an artificially cultivated wild ginseng germinated from bird feces. Although numerous pharmacologic activities of wild ginsengs have been reported, the beneficial effect of joboksansam in cancer has not been elucidated. In this study, we investigated the in vivo and in vitro anticancer activities of joboksansam powder.MethodsTo evaluate the in vivo anticancer activity of joboksansam, we established a xenograft mouse model bearing RMA cell-derived cancer. Direct cytotoxicity induced by joboksansam powder was also investigated in vitro using (3-4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) assay. The inhibitory activity of this powder on the activation of cell survival signaling involving Akt and Src was examined with immunoblot analysis.ResultsJoboksansam powder displayed strong inhibitory activity against the increased tumor size, increased weight of total body and cancer tissues, and mortality of tumor-bearing mice. Joboksansam powder also suppressed the activation of survival regulatory enzymes Akt and Src, as assessed by phosphorylation levels in the immunoblot analysis of tumor tissues. Interestingly, the viability of RMA cells in vitro was directly decreased by joboksansam treatment.ConclusionOverall, our results strongly suggest that joboksansam powder has the potential to protect against cancer generation by direct cytotoxic effects on cancer cells resulting from suppression of cell survival signaling.

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Section: Introductionmentioning

confidence: 99%

Anticancer effect of joboksansam, Korean wild ginseng germinated from bird feces

Park

Kang²,

Park

et al. 2016

Journal of Ginseng Research

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“…It has been reported that ginseng has a wide range of pharmacological activities in cardiovascular, endocrine, immune, and central nervous systems (Bhattaacharya and Mitra 1991). It is especially well established that ginseng ameliorates inflammatory responses (Jin et al 2008;Park et al 2012;Yang et al 2014). Red ginseng is made by steaming and drying the fresh ginseng.…”

Section: Introductionmentioning

confidence: 99%

Red ginseng represses hypoxia-induced cyclooxygenase-2 through sirtuin1 activation

et al. 2015

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“…Korean red ginseng has been widely used as a traditional herbal medicine in Asia (3). Numerous studies have reported that Korean red ginseng exerts several beneficial properties such as anti-aging, anti-fatigue, anti-stress, anti-atherosclerosis, anti-diabetic, and anticancer activities (3).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have reported that Korean red ginseng exerts several beneficial properties such as anti-aging, anti-fatigue, anti-stress, anti-atherosclerosis, anti-diabetic, and anticancer activities (3). Moreover, a recently published animal study indicates that the consumption of Korean red ginseng is associated with anti-inflammatory effects in high-fat (HF) diet induced atherosclerosis (4).…”

Section: Introductionmentioning

confidence: 99%

High Hydrostatic Pressure Extract of Red Ginseng Attenuates Inflammation in Rats with High-fat Diet Induced Obesity

Jung¹,

Lee²,

Shin³

et al. 2015

JFN

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Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, SpragueDawley rats (80∼110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptor-gamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression.

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ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

Cited by 50 publications

References 68 publications

Anticancer effect of joboksansam, Korean wild ginseng germinated from bird feces

Anticancer effect of joboksansam, Korean wild ginseng germinated from bird feces

Red ginseng represses hypoxia-induced cyclooxygenase-2 through sirtuin1 activation

High Hydrostatic Pressure Extract of Red Ginseng Attenuates Inflammation in Rats with High-fat Diet Induced Obesity

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