At What Age Threshold does the Decline in Semen Parameters Begin?

Demirkol, Mehmet; Barut, Osman; Doğan, Neslihan; Hamarat, Mustafa Bilal; Resim, Sefa

doi:10.29271/jcpsp.2021.01.4

Cited by 8 publications

(5 citation statements)

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“…Surprisingly, although nonshift workers were older and had a higher rate of smoking than shift workers in the present study, shift workers still had a lower semen quality. A recent study demonstrated a linear decrease in sperm motility, morphology and vitality as age advanced in infertile men (Demirkol et al, 2021). In another study, it was demonstrated that smoking had an independent negative effect on sperm concentration (De Brucker et al, 2020).…”

Section: Discussionmentioning

confidence: 93%

Evaluation of the effect of shift working and sleep quality on semen parameters in men attending infertility clinic

et al. 2021

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We aimed to evaluate the effect of shift work on semen parameters together with the effect of sleep quality in men attending infertility clinic. The participants were divided into two groups as follows: 104 shift worker men (Group 1) and 116 nonshift worker men (Group 2). Groups were compared in terms of semen parameters, Depression Anxiety Stress Scale-21 (DASS-21), and Pittsburg Sleep Quality Index (PSQI) scores. A higher rate of oligozoospermia and poor sleep quality and a lower mean normal morphology percentage was observed in shift workers than nonshift workers (p = .006, .039 and .036 respectively). In addition, a positive correlation was seen between sleep duration and sperm concentration, while a negative correlation was found between sleep latency and total sperm count. Shift working together with high PSQI score was also a significant association with oligozoospermia when controlling for the other variables of age, total testosterone, DASS-21 stress score, smoking and varicocele (OR = 2.11, 95% CI 1.03-4.34 and OR = 1.18, 95% CI 1.01-1.39 respectively). In this study, infertile shift workers had a lower percentage of normal morphology and higher rates of oligozoospermia and poor sleep quality.Considering that shift workers have lower sleep quality, it seems that shift working negatively affects the circadian rhythm. K E Y W O R D S semen parameter, shift work, sleep quality 2 of 7 | DEMIRKOL Et aL.shift work can undermine sleep quality by interfering with the body's natural circadian rhythm. Likewise, it was shown in a study that shift work is an independent risk factor for poor sleep quality (McDowall et al., 2017). Furthermore, shift work has been related to several health outcomes, including metabolic disorders, cardiovascular disease, mood disorders, as well as male reproductive disorders (Bara & Arber, 2009;

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Section: Discussionmentioning

confidence: 93%

Evaluation of the effect of shift working and sleep quality on semen parameters in men attending infertility clinic

et al. 2021

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“…A significant body of evidence consistently indicates a decrease in semen volume, motility, and the proportion of morphologically normal sperm with advancing age. Overall, the most consistent findings include APA's negative correlation with semen volume (7 of 9 studies) and motility (9 of 10 studies) as well as positive correlation with DNA fragmentation (11 of 11 studies) [4,[18][19][20]. Among others, a study involving 277 normozoospermic men revealed a significantly higher DNA Fragmentation Index (DFI) percentage in men older than 40 years compared to younger men [21].…”

Section: Introductionmentioning

confidence: 76%

Paternal Age Amplifies Cryopreservation-Induced Stress in Human Spermatozoa

Pérez Casasús,

Luongo,

Haxhiu

et al. 2024

Cells

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The global fall in male fertility is a complicated process driven by a variety of factors, including environmental exposure, lifestyle, obesity, stress, and aging. The availability of assisted reproductive technology (ART) has allowed older couples to conceive, increasing the average paternal age at first childbirth. Advanced paternal age (APA), most often considered male age ≥40, has been described to impact several aspects of male reproductive physiology. In this prospective cohort study including 200 normozoospermic patients, 105 of whom were ≤35 years (non-APA), and 95 of whom were ≥42 years (APA), we assessed the impact of paternal age on different endpoints representative of sperm quality and cryopreservation tolerance. Non-APA patients had superior fresh semen quality; DNA fragmentation was notably increased in APA as compared to non-APA individuals (21.7% vs. 15.4%). Cryopreservation further increased the DNA fragmentation index in APA (26.7%) but not in non-APA patients. Additionally, APA was associated with increased mtDNAcn in both fresh and frozen/thawed sperm, which is indicative of poorer mitochondrial quality. Cryopreservation negatively impacted acrosome integrity in both age groups, as indicated by reduced incidences of unreacted acrosome in relation to fresh counterparts in non-APA (from 71.5% to 57.7%) and APA patients (from 75% to 63%). Finally, cryopreservation significantly reduced the phosphorylation status of proteins containing tyrosine residues in sperm from young males. Therefore, the present findings shed light on the effects of paternal age and cryopreservation on sperm quality and serve as valuable new parameters to improve our understanding of the mechanisms underlying sperm developmental competence that are under threat in current ART practice.

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“…It is important to know if older paternal age is associated with worse semen quality and an increased risk of infertility because more and more couples are seeking assistance from infertility clinics to establish babies later in life. Age was found to have a substantial impact on sperm volume, motility, and fast advancing motility [3] .…”

Section: Introductionmentioning

confidence: 93%

Semenogram Characteristics in Correlation with Hormonal Studies among Different Age Groups of Men - Damietta Governorate

Megahed,

Zaky,

ElGhannam

et al. 2024

International Journal of Medical Arts

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Article informationBackground: The average age of first reproduction has increased dramatically throughout the world in recent decades. New evidence suggests that older parents have lower fertility and less healthy children. Most of these studies focused on men over the age of 60 who were infertile. Few studies have looked at how age affects normally fertile men under the age of 60.Aim of the work: Assess the semenogram using Computer assisted semen analysis [CASA] and Hormonal studies that will include total and free testosterone, FSH, LH, Estrogen, prolactin and TSH in Egyptian men between age groups of 20 and 50 years in Damietta governorate, to assess if there is a decline in the overall parameters of sperm.

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At What Age Threshold does the Decline in Semen Parameters Begin?

Abstract: Objective: To analyse changes in semen parameters according to different age groups in men presenting to an infertility clinic, and determine the age threshold for decline in semen quality.

Cited by 8 publications

References 0 publications

Evaluation of the effect of shift working and sleep quality on semen parameters in men attending infertility clinic

Evaluation of the effect of shift working and sleep quality on semen parameters in men attending infertility clinic

Paternal Age Amplifies Cryopreservation-Induced Stress in Human Spermatozoa

Semenogram Characteristics in Correlation with Hormonal Studies among Different Age Groups of Men - Damietta Governorate

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