At-line coupling of hollow fiber liquid-phase microextraction to capillary electrophoresis for trace determination of acidic drugs in complex samples

Miková, Blanka; Dvorak, M.W.; Ryšavá, Lenka; Malá, Zdeňka; Gebauer, Petr; Kubáň, Pavel

doi:10.1016/j.talanta.2021.123068

Cited by 36 publications

(12 citation statements)

References 30 publications

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“…Among other clever approaches, it is worth mentioning the possibility to use the capillary to add solvents and mix the sample to determine tyrosine kinase inhibitors in plasma [384], additional uses of droplet extraction [477], including single bubble in-tube microextraction [478], and the use of alternative solvents [479] such as deep eutectic solvents [480] or ionic liquids [481]. Pavel Kuban's group recently reported the advantages of at-line coupling of hollow fiber liquid-phase microextraction to CE for trace determination of basic [482,483] and acidic drugs [484] in complex samples. Although this approach is established, they considered a 3D-printed microextraction device (inexpensive and disposable, Figure 7) with a hollow fiber placed in the sample vial of a commercial CE instrument.…”

Section: Passive Sample Pretreatment Stepsmentioning

confidence: 99%

“…Pavel Kuban's group recently reported the advantages of at‐line coupling of hollow fiber liquid‐phase microextraction to CE for trace determination of basic [482, 483] and acidic drugs [484] in complex samples. Although this approach is established, they considered a 3D‐printed microextraction device (inexpensive and disposable, Figure 7) with a hollow fiber placed in the sample vial of a commercial CE instrument.…”

Section: Direct Injection Sample Pretreatment and Preconcentrationmentioning

confidence: 99%

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Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition

et al. 2023

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This review is in support of the development of selective, precise, fast, and validated capillary electrophoresis (CE) methods. It follows up a similar article from 1998, Wätzig H, Degenhardt M, Kunkel A. “Strategies for capillary electrophoresis: method development and validation for pharmaceutical and biological applications,” pointing out which fundamentals are still valid and at the same time showing the enormous achievements in the last 25 years. The structures of both reviews are widely similar, in order to facilitate their simultaneous use. Focusing on pharmaceutical and biological applications, the successful use of CE is now demonstrated by more than 600 carefully selected references. Many of those are recent reviews; therefore, a significant overview about the field is provided. There are extra sections about sample pretreatment related to CE and microchip CE, and a completely revised section about method development for protein analytes and biomolecules in general. The general strategies for method development are summed up with regard to selectivity, efficiency, precision, analysis time, limit of detection, sample pretreatment requirements, and validation.

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Section: Passive Sample Pretreatment Stepsmentioning

confidence: 99%

Section: Direct Injection Sample Pretreatment and Preconcentrationmentioning

confidence: 99%

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition

et al. 2023

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“…Liquid-liquid microextraction can be supplemented with further separation methods, such as capillary electrophoresis, for an augmented preconcentration effect, as demonstrated for a series of acidic drugs (warfarin, ibuprofen, naproxen, ketoprofen, and diclofenac) in spiked human capillary blood [ 49 ]. Enrichment factors in the range of 29–97 and LoD values in the range of 0.2–3.4

g/dm 3 were achieved.…”

Section: Literature Reviewmentioning

confidence: 99%

Micropreconcentrators: Recent Progress in Designs and Applications

Stolarczyk

Jarosz

2022

Sensors

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The detection of chemicals is a fundamental issue of modern civilisation, however existing methods do not always achieve the desired sensitivity. Preconcentrators, which are devices that allow increasing the concentration of the intended analyte via e.g., adsorption/desorption, are one of the solutions for increasing the sensitivity of chemical detection. The increased detection sensitivity granted by preconcentration can be used to miniaturise detection instruments, granting them portability. The primary goal of this review is to report on and briefly explain the most relevant recent developments related to the design and applications of preconcentrators. The key design elements of preconcentrators and the emerging area of liquid-phase preconcentrators are briefly discussed, with the most significant applications of these devices being highlighted.

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“…SBME is an equilibrium rather than exhaustive technique and to reach the equilibrium point different parameters (such as type of organic solvent, solution pH, extraction time, and desorption conditions) must be optimized. SBME operational factors are optimized using the classical method by adjusting a single factor while keeping others constant (Miková et al, 2022; Rutkowska et al, 2019; Seidi et al, 2018). The single‐factor procedure is effective but consumes time and materials when dealing with multifactors, so appropriate multivariate experimental designs such as full fractional design (FFD), Box–Behnken, and central composite design (CCD) are advised (Brereton, 2007; Darvishnejad et al, 2021; Rajski et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of furosemide and carbamazepine in biological matrices by solvent bar microextraction combined with high‐performance liquid chromatography–diode array detector and central composite design

Al-Hashimi

Al‐Degs

Jaafreh

et al. 2022

Biomedical Chromatography

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A sensitive and simple sample pretreatment method based on a two-phase solvent bar microextraction (SBME) technique coupled with HPLC-diode array detector (DAD) was developed for simultaneous extraction and determination of trace amounts of furosemide and carbamazepine in human urine and plasma samples. The significance of operational factors on carbamazepine and furosemide extraction efficiency % (EE%) was screened using full factorial design (FFD) while central composite design (CCD) was used to model the entire process. A quadratic model was found convenient to correlate the extraction EE% of selected drugs with dominant experimental factors. A Pareto chart was also used to examine the importance of factors on drugs' EE%. The analytical performance of the method in urine and plasma samples demonstrated good linearity (R 2 > 0.992) with detection limits ranging from 4.2 to 10.9 μg L À1 , and extraction recovery over 89.45% for both drugs in urine and plasma samples. A comparison against published methods was also performed and the results revealed that the developed method exhibits a confident sensitivity, feasible operation, and simple analysis for both drugs. Finally, the practicability of the validated SBME-HPLC-DAD method was demonstrated by successfully applying it to the analysis of furosemide and carbamazepine in real patient urine samples.biological matrices, central composite design, design of experiment, furosemide and carbamazepine, HPLC-DAD, solvent bar microextraction | INTRODUCTIONFurosemide (FUR), 4-chloro-N-furfuryl-5-sulfamoyl-anthranilic acid, is a potent loop diuretic and frequently used in the treatment of edematous states related to chronic failure, hypertension, or cirrhosis of the liver (Krisanapan et al., 2020). FUR is rapidly but incompletely absorbed after oral administration and highly bound to plasma proteins (>90%; Wenk et al., 2006), with up to 50% of a dose eliminated by urinary excretion, mainly as an unchanged drug (Oh & Han, 2015). Carbamazepine (CBZ), 5-H-dibenze[b,f]azepine-5-carboxamide, is a tricyclic lipophilic compound used as an anticonvulsant and mood-stabilizing drug in the treatment and prevention of seizures caused by epilepsy (Lawthom et al., 2018). After oral administration,

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At-line coupling of hollow fiber liquid-phase microextraction to capillary electrophoresis for trace determination of acidic drugs in complex samples

Cited by 36 publications

References 30 publications

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition

Micropreconcentrators: Recent Progress in Designs and Applications

Simultaneous determination of furosemide and carbamazepine in biological matrices by solvent bar microextraction combined with high‐performance liquid chromatography–diode array detector and central composite design

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