Asymptomatic uveitis in young people with inflammatory bowel disease

Rychwalski, Paul J.; Cruz, Oscar A.; Alanis-Lambreton, Gerardo; Foy, Thomas M.; Kane, Robert E.

doi:10.1016/s1091-8531(97)90009-4

Cited by 21 publications

(11 citation statements)

References 12 publications

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“…Bowel inflammation typically precedes ocular symptoms [3]; however, ocular inflammation occasionally precedes inflammatory involvement of the bowel. Furthermore, 0.56% of all patients with uveitis suffer from inflammatory bowel disease [4]; uveitis often correlates to arthritis/arthralgias, ankylosing spondylitis and HLA-B27 marker.…”

Section: Discussionmentioning

confidence: 99%

Uveitis preceding Crohn’s disease by 8 years

et al. 2011

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We report the clinical history of a child affected by Crohn's disease in which uveitis precedes intestinal involvement by years and occurs with the atypical features of anterior chronic inflammation complicated by unilateral optic disc edema, rather than recurrent anterior uveitis with sudden onset which has been more widely reported in inflammatory bowel diseases. The uveitis onset occurred 8 years before symptoms of the primary intestinal disease, while in inflammatory bowel diseases the intestinal inflammation typically precedes ocular symptoms, and ocular inflammation only occasionally precedes inflammatory involvement of the bowel.

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Section: Discussionmentioning

confidence: 99%

Uveitis preceding Crohn’s disease by 8 years

et al. 2011

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“…So wurden asymptomatische Uveitiden (ohne Klassifizierung) bei Kindern und jungen Erwachsenen beschrieben. Auch hier macht die Seltenheit einer Augenbeteiligung eine sorgfältige Differenzialdiagnose notwendig, um asymptomatische Verläufe und eine Uveitis intermedia überhaupt zu erkennen [21,33] Uveitis intermedia und infektionsassoziierte Erkrankungen Im postinfektiçsen Verlauf kann es nach verschiedenen Erkrankungen zu einer Uveitis kommen, beispielsweise nach Salmonellose, Yersiniose, Borreliose oder Infektionen mit Chlamydien oder Mykoplasmen. Zirkulierende kreuzreagierende Antikçrper sind vermutlich dafür verantwortlich, deren Ziel Anteile der Uvea sein kçnnen, je nach genetischer Disposition des Betroffenen.…”

Section: Crohn Und Multiple Skleroseunclassified

Uveitis intermedia im Kindesalter

Engelmann¹,

Neß²,

Greiner³

et al. 2007

Klin Monatsbl Augenheilkd

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Round 10-12% of all children who present with signs of uveitis suffer from intermediate uveitis. Compared to uveitis anterior in children, the association of intermediate uveitis to a systemic disease is much more complicated. Most cases of uveitis intermedia are idiopathic and show the signs of a pars planitis. Post-infectious and immunological causes are difficult to detect. In cases of uveitis in children, it is necessary to know the specific symptoms of possible underlying systemic diseases. On this basis, an adequate and specific diagnosis will most probably be successful. This paper presents the different causes of uveitis intermedia in childhood and compares the incidence of the disease in comparison with adults as far as this is mentioned in the literature.

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“…Whether dysbiosis represents the cause or result of IBD (reviewed in [38]), it is a correlated biomarker of extraintestinal inflammatory disease (reviewed in [25,39]). While mechanistic evidence is still limited, dysbiosis has long been linked to AD [40], including noninfectious uveitis [41][42][43], (reviewed in [25]), often occurring simultaneously with acute flare-ups of colitis [44]. Thus, it can be seen that dysbiosis and similar microbiota-related environmental factors impact up to 70% of all AD [45,46], and while the etiology of IBD itself is not fully understood, it is considered to be the result of an interplay between environment/nutrition, microbiota, gastrointestinal immunity, and epigenetics.…”

Section: The Colonic Microbiota Shapes the Host's Healthmentioning

confidence: 99%

A Role for Folate in Microbiome-Linked Control of Autoimmunity

Mölzer

Kuffová

Forrester

2021

Journal of Immunology Research

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The microbiome exerts considerable control over immune homeostasis and influences susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), psoriasis, and uveitis. In part, this is due to direct effects of the microbiome on gastrointestinal (GI) physiology and nutrient transport, but also to indirect effects on immunoregulatory controls, including induction and stabilization of T regulatory cells ( T reg ). Secreted bacterial metabolites such as short-chain fatty acids (SCFA) are under intense investigation as mediators of these effects. In contrast, folate (vitamin B9), an essential micronutrient, has attracted less attention, possibly because it exerts global physiological effects which are difficult to differentiate from specific effects on the immune system. Here, we review the role of folate in AD/AID with some emphasis on sight-threatening autoimmune uveitis. Since folate is required for the generation and maintenance of T reg , we propose that one mechanism for microbiome-based control of AD/AID is via folate-dependent induction of GI tract T reg , particularly colonic T reg , via anergic T cells ( T an ). Hence, folate supplementation has potential prophylactic and/or therapeutic benefit in AID/AD.

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Asymptomatic uveitis in young people with inflammatory bowel disease

Cited by 21 publications

References 12 publications

Uveitis preceding Crohn’s disease by 8 years

Uveitis preceding Crohn’s disease by 8 years

Uveitis intermedia im Kindesalter

A Role for Folate in Microbiome-Linked Control of Autoimmunity

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