Uveitis intermedia im Kindesalter

Engelmann, Katrin; Neß, Thomas; Greiner, Kathrin; Hudde, Tobias

doi:10.1055/s-2007-963303

Cited by 4 publications

(5 citation statements)

References 32 publications

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“…IU affects patients in all age groups, from children to adults. 2,16 The mean age at disease onset of our patients was 19.4 years, younger than reported in other populations like Grajewski et al 17 Usually, the prevalence of females and males is similar as found in our study. 2 However, Paroli et al 18,19 and Silpa-Archa et al 20 found a slightly greater female 21 found a male predominance in patients with pars planitis.…”

Section: Discussionsupporting

confidence: 83%

“…IU affects patients in all age groups, from children to adults. 2 , 16 The mean age at disease onset of our patients was 19.4 years, younger than reported in other populations like Grajewski et al 17 in Germany and Vidovic-Valentincic et al 7 in Slovenia where the average age at onset was 44 years and 31 years, respectively.…”

Section: Discussioncontrasting

confidence: 46%

“…Similarly, other studies reported systemic corticosteroids to be the most common treatment, followed by oral immunosuppressive therapy. 6 , 15 , 16 , 21 , 35 Refractory cases can require biological therapy, 36 in our study it was used in three patients, and one of them had to change the biologic drug once.…”

Section: Discussionmentioning

confidence: 76%

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Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center

Rojas-Carabali¹,

Reyes-Guanes²,

Villabona-Martínez³

et al. 2021

OPTH

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Purpose To analyze the etiology, clinical characteristics, complications, treatments, and outcomes of patients with intermediate uveitis examined in a uveitis referral center in Bogotá, Colombia. Patients and Methods We conducted a retrospective descriptive study. We reviewed systematically the clinical records of patients attending a uveitis referral center in Bogotá, Colombia from 2013 to 2020. Data analysis included demographics, etiology, clinical characteristics, treatment modalities, best-corrected visual acuity, and complications. For categorical variables, absolute and relative frequencies were used while for continuous variables mean and standard deviations were calculated. Results We identified 18 patients with intermediate uveitis. The mean age at disease onset was 19.4 years. There was no sex predominance. Two-thirds of the patients presented bilateral involvement. The mean initial best-corrected visual acuity was 0.19 LogMAR. The most common etiology was idiopathic followed by undetermined, tuberculosis, multiple sclerosis, and juvenile idiopathic arthritis. The most common characteristics were insidious onset, chronic course, and persistent duration. The complications found were macular edema, optic disk edema, cataract, epiretinal membrane, among others. Corticosteroids and immunosuppressive therapy were the most common treatments. Mean follow-up time was 24.4 months, and the mean final best-corrected visual acuity was 0.12 LogMAR. Conclusion This is the first study describing intermediate uveitis features in South America. In our context, intermediate uveitis is infrequent. Polyautoimmunity and familial autoimmunity phenomena were found in some patients. These may require a multidisciplinary approach. Ophthalmologists should promptly diagnose, treat, and refer patients with this disease to avoid common complications. Further studies are required to determine the disease relation with polyautoimmunity.

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Section: Discussionsupporting

confidence: 83%

“…IU affects patients in all age groups, from children to adults. 2 , 16 The mean age at disease onset of our patients was 19.4 years, younger than reported in other populations like Grajewski et al 17 in Germany and Vidovic-Valentincic et al 7 in Slovenia where the average age at onset was 44 years and 31 years, respectively.…”

Section: Discussioncontrasting

confidence: 46%

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Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center

Rojas-Carabali¹,

Reyes-Guanes²,

Villabona-Martínez³

et al. 2021

OPTH

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“…Im Gegensatz dazu verläuft die Uveitis intermedia im Kindesalter analog zum Erwachsenenalter in 80 % idiopathisch [3,4]. Sarkoidose, MS, chronisch entzündliche Darmerkrankungen sowie eine postinfektiöse Ursache müssen trotzdem ausgeschlossen werden, da die idiopathische Genese eine Ausschlussdiagnose darstellt [5]. Eine Uveitis posterior wird dagegen im Kindesalter meistens durch eine infektiöse Ursache ausgelöst, wobei hier an 1.…”

Section: äTiologie Der Uveitis Intermedia Und Posteriorunclassified

“…Stelle die Toxoplasmose-Retinochorioiditis zu nennen ist. Borrelien, Toxocara, Syphilis und Tbc sind deutlich seltener als Ursache zu finden [5].…”

Section: äTiologie Der Uveitis Intermedia Und Posteriorunclassified

Therapie der kindlichen Uveitis intermedia und posterior mit intravitrealen Steroiden

Winterhalter¹

2019

Arthritis und Rheuma

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ZUSAMMENFASSUNGDie Uveitis im Kindesalter weist ein hohes Erblindungsrisiko auf. Bei einer nicht infektiösen Uveitis intermedia und posterior sind lokal applizierte Steroid-Augentropfen nicht ausreichend wirksam, sodass bei Visusverschlechterung und Komplikationen eine systemische Therapie erfolgen muss. Diese entspricht im Wesentlichen dem Therapiealgorithmus der JIA-Assoziierten Uveitis anterior wie in der S2k-Leitlinie 045–012 zur Diagnostik und antientzündlichen Therapie der Uveitis bei juveniler idiopathischer Arthritis mit Stand 01/2018 beschrieben. Bei pädiatrischen Patienten jedoch, die nur an einem Auge ohne Systemerkrankung leiden, wäre eine intravitreale Therapie wünschenswert, um Nebenwirkungen einer systemischen Therapie zu vermeiden. Intravitreal verabreichte Steroide weisen zwar eine sehr gute Wirksamkeit auf. Leider besteht jedoch das Risiko für ein Steroid-induziertes Glaukom sowie eine Steroid-induzierte Katarakt, sodass intravitreal verabreichte Steroide laut S2k-Leitlinie nur als Rescue-Therapie genutzt werden sollten.

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Intermediate Uveitis

Pradeep¹,

Biswas²

2016

Uveitis: An Update

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Uveitis intermedia im Kindesalter

Cited by 4 publications

References 32 publications

Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center

Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center

Therapie der kindlichen Uveitis intermedia und posterior mit intravitrealen Steroiden

Intermediate Uveitis

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