Asymptomatic nodules on the chest. Cutaneous sinus histiocytosis (CSH) (cutaneous Rosai-Dorfman disease)

Cutaneous Rosai‐Dorfman disease in a 3‐year‐old boy

“…Saenz‐Santamaria et al reported a clinicopathological confirmed case of CRDD in a 16‐year‐old female who developed firm, skin‐colored, dome‐shaped papules and nodules that arose over chickenpox scars. She had no systemic symptoms, and normal laboratory and imaging studies 15 . Requena et al described the case of a 77‐year‐old male patient recently diagnosed with a gastric B‐cell centroblastic lymphoma, who developed erythematous nodules with a dermatomal distribution on the chest in sites of previous herpes zoster involvement 16 …”

“…Emperipolesis (presence of intact inflammatory cells within histiocytes) is a specific finding of the disease 3,19 . Classic immunohistochemistry is positive for S‐100, CD4, factor XIIIa, CD68, and negative for CD1a 3,15,20 …”

“…The main associated viruses are human herpesvirus type 6, EBV, parvovirus B19, and varicella-zoster virus (VZV). 1,2,14 VZV infection related to RDD has been previously described in one adolescent with CRDD 15 and an adult with neoplasm-associated sporadic RDD. 16 Saenz-Santamaria et al reported a clinicopathological confirmed case of CRDD in a 16-year-old female who developed firm, skincolored, dome-shaped papules and nodules that arose over chickenpox scars.…”

“…She had no systemic symptoms, and normal laboratory and imaging studies. 15 Requena et al described the case of a 77-year-old male patient recently diagnosed with a gastric B-cell centroblastic lymphoma, who developed erythematous nodules with a dermatomal distribution on the chest in sites of previous herpes zoster involvement. 16 Previous infection with EBV has been associated with both systemic and cutaneous forms of RDD.…”

“…3,19 Classic immunohistochemistry is positive for S-100, CD4, factor XIIIa, CD68, and negative for CD1a. 3,15,20 The differential diagnoses include cutaneous lymphoid hyperplasia, granuloma annulare, Jessner's lymphocytic infiltrate, xanthoma, juvenile xanthogranuloma, Langerhans cell histiocytosis, and B and T-cell lymphomas, among others. 2,14 CRDD usually has a benign course, with the possibility of spontaneous remission.…”