Asymptomatic Gastric Ulcer: A Follow-Up Study in Patients With Previous Gastric Ulcer Disease

Jorde, Rolf; Bostad, Leif; Burhol, P. G.

doi:10.1016/s0140-6736(86)92260-9

Cited by 33 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reason why some ulcers are asymptomatic is unknown. In controlled trials, both asymptomatic duodenal ulcers and gastric ulcers have been found in a substantial proportion of cases (44,45). We found that eight subjects (19.5 percent of all ulcer patients and 0.8 percent of the study population) had asymptomatic PUD.…”

Section: Discussionmentioning

confidence: 66%

Peptic Ulcer Disease in a General Adult Population

Aro¹,

Storskrubb²,

Ronkainen³

et al. 2006

American Journal of Epidemiology

161

View full text Add to dashboard Cite

The authors' aim in this study was to explore the prevalence, symptomatology, and risk factors for peptic ulcer in a general adult population. Between December 1998 and June 2001, the authors surveyed a random sample (n=3,000) of the adult population (n=21,610) in two communities in northern Sweden using a validated questionnaire, the Abdominal Symptom Questionnaire (response rate=74%). A subsample (n=1,001) of the responders was randomly invited to undergo esophagogastroduodenoscopy and symptom assessment (response rate=73%). The prevalence of peptic ulcer was 4.1% (20 gastric ulcers and 21 duodenal ulcers). Nausea and gastroesophageal reflux were significant predictors of peptic ulcer disease, but epigastric pain/discomfort was not. Six persons with gastric ulcer and two persons with duodenal ulcer were asymptomatic. Eight subjects with duodenal ulcer (38%) lacked evidence of current Helicobacter pylori infection. Five (25%) of the gastric ulcers and four (19%) of the duodenal ulcers were idiopathic (no use of aspirin or nonsteroidal antiinflammatory drugs, no H. pylori infection). Smoking, aspirin use, and obesity were risk factors for gastric ulcer; smoking, low-dose (

show abstract

Section: Discussionmentioning

confidence: 66%

Peptic Ulcer Disease in a General Adult Population

Aro¹,

Storskrubb²,

Ronkainen³

et al. 2006

American Journal of Epidemiology

161

View full text Add to dashboard Cite

show abstract

“…These findings on the impact of PPIs on peptic ulcer argue in favour of, but may be insufficient to justify the co‐administration of PPIs. First, the clinical relevance of peptic ulcer prevention is unclear because peptic ulcer is a poor predictor of ulcer complications and can remain asymptomatic . In addition, only seven studies, of which five were observational, were included in the meta‐analysis.…”

Section: Discussionmentioning

confidence: 99%

Should patients prescribed long-term low-dose aspirin receive proton pump inhibitors? A systematic review and meta-analysis

et al. 2015

View full text Add to dashboard Cite

Background: Several clinical guidelines recommend the use of proton pump inhibitors (PPIs) in patients taking low-dose aspirin but report no or limited supporting data. We conducted a systematic review and meta-analysis to examine the effects of co-administration of PPIs in patients taking low-dose aspirin on the risks of adverse gastrointestinal (GI) and cardiovascular (CV) events, and on patient adherence to aspirin. Methods: We searched PUBMED, EMBASE and Cochrane Central Register of Controlled Trials databases for relevant articles published through November 2013. We included randomised controlled trials (RCTs) and observational studies in patients taking low-dose aspirin with and without PPIs. Risk of bias was assessed using the Cochrane Collaboration's tool (for RCTs) and the Newcastle-Ottawa Scale (for observational studies). Pooled risk ratios (RRs) were computed using a random-effects model. Results: We included 13 studies, of which 12 (2 RCTs and 10 observational studies) reported on GI events, and one (cohort study) on both GI bleeding and CV events. No study reported on adherence to aspirin. Co-administration of PPIs in patients receiving low-dose aspirin was associated with risk reductions of 73% (RR 0.27, 95% CI 0.17-0.42) and 50% (RR 0.50, 95% CI 0.32-0.80) in the occurrence of peptic ulcer and GI bleeding respectively. There was evidence of bias in publications reporting on the GI events. Conclusions: The practice of co-prescribing PPIs in patients taking lowdose aspirin is supported by some data, but the evidence is rather weak. It currently remains unclear whether the benefits of co-administration of PPIs in users of low-dose aspirin outweigh their potential harms. Review criteria• Randomised controlled trials (RCTs) and observational studies in patients receiving lowdose aspirin.• Studies reporting on adverse gastrointestinal or cardiovascular events, or adherence to aspirin.

show abstract

“…A number of studies and case reports have highlighted the risk of occult gastric cancers occurring in apparently benign ulcers (4,13-18). However, several studies suggest that the risk of gastric cancer in apparently benign gastric ulcer is very low (5)(6)(7)9). In a large study of 1812 Japanese patients with gastric ulcers, 38 patients developed gastric cancer a mean of 6.1 years after the initial diagnosis of gastric ulcer (8).…”

Section: Discussionmentioning

confidence: 99%

“…It is suggested that such a practice leads to the detection of early gastric cancers at a treatable stage. The merits of this practice have been questioned by a number of investigators (5)(6)(7)(8)(9). However, international guidelines still recommend repeat endoscopy in the follow-up of all cases of gastric ulcer (10,11).…”

Section: Sondage Sur Les Pratiques Actuelles Des Membres De La Scg Qumentioning

confidence: 99%

Survey of Current Practices among Members of CAG in the Follow-Up of Patients Diagnosed with Gastric Ulcer

Breslin

Sutherland

1999

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

Asymptomatic Gastric Ulcer: A Follow-Up Study in Patients With Previous Gastric Ulcer Disease

Cited by 33 publications

References 7 publications

Peptic Ulcer Disease in a General Adult Population

Peptic Ulcer Disease in a General Adult Population

Should patients prescribed long-term low-dose aspirin receive proton pump inhibitors? A systematic review and meta-analysis

Survey of Current Practices among Members of CAG in the Follow-Up of Patients Diagnosed with Gastric Ulcer

Contact Info

Product

Resources

About