Asymptomatic Extrapyramidal Involvement in Pick's Diease

Winkelman, N. W.; Book, Marius

doi:10.1097/00005072-194901000-00002

Cited by 27 publications

(9 citation statements)

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“…However, the case reported by Akelaitis did not have Pick bodies. Winkelman and Book reported two autopsy cases of Pick's disease without Pick bodies, and described marked neuronal loss in the basal ganglia, prominently in the caudate nucleus and substantia nigra 16 . Constantinidis et al and Constantinidis reported that the basal ganglia in group A Pick's disease showed only very slight gliosis, with the amygdala being the center of atrophy 7,8 .…”

Section: Discussionmentioning

confidence: 99%

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Distribution of basal ganglia lesions in Pick's disease with Pick bodies: A topographic neuropathological study of eight autopsy cases

et al. 1999

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The distribution of the basal ganglia lesions, including the amygdala, striatum, and pallidum, were investigated neuropathologically in eight Japanese autopsy cases of Pick's disease with Pick bodies. The lesions were classified as mild, moderate or severe. The degree and distribution of basal ganglia lesions in all eight cases were uniform: the amygdala showed severe to moderate lesions, the caudate nucleus and putamen showed moderate to mild lesions, and the pallidum showed mild lesions. Furthermore, the lesions in the amygdala were more prominent in the basolateral group than in the corticomedial group. In Pick's disease with Pick bodies, the degree and distribution of the lesions within the basal ganglia differs from those reported in both ‘Pick's disease without Pick bodies’ and corticobasal degeneration (CBD), in which severe lesions were present in the pallidum. These neuropathological findings may contribute to the morphological differential diagnosis among Pick's disease with Pick bodies, ‘Pick's disease without Pick bodies’, and CBD.

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Section: Discussionmentioning

confidence: 99%

“…It is well known that involvement of the basal ganglia often occurs in Pick's disease 6,12–21 . Van Mansvelt reported that caudate atrophy was present in two‐thirds of cases reviewed in the literature 6 .…”

Section: Introductionmentioning

confidence: 99%

Distribution of basal ganglia lesions in Pick's disease with Pick bodies: A topographic neuropathological study of eight autopsy cases

et al. 1999

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“…Subcortical pathology was often demonstrated in PiD and later in FTD [4,5]. However, subcortical pathology is not always associated with extrapyramidal symptomatology [3,6].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Frontotemporal Dementia and Corticobasal Degeneration/Progressive Supranuclear Palsy

Kertesz

Muñoz²

2004

Dement Geriatr Cogn Disord

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Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) were described as separate entities, but prior to that an extrapyramidal variety of Pick’s disease was recognized. Subsequently a pathological overlap between these conditions and clinical overlap between frontotemporal dementia, primary progressive aphasia, corticobasal degeneration syndrome and more recently PSP was recognized. Initially only the movement disorder had been emphasized, but now the behavioral and language symptoms are considered common. The syndromes of frontotemporal dementia/Pick’s disease can be produced by underlying CBD, PSP or Pick pathology as well as with neural inclusions of the motor neuron disease type. The concept of this overlap has been confirmed genetically finding a similar spectrum of pathology with different tau mutations and even with tau negative pathology, which could be a deficiency of normal tau. The overlap of CBD with PSP and both with PPA and FTD allows to consider these relatively rare conditions as part of a more commonly occurring degenerative disease than previously recognized.

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“…Subsequent descriptions of extrapyramidal symptoms in Pick's disease (PiD) also appeared [7,8]. Frontal lobe degeneration (FLD) [9,10], later renamed frontotemporal dementia (FTD) [11], primary progressive aphasia (PPA) [12], their combination with motor neuron disease (MND) [13,14], and corticonigral or corticobasal degeneration (CBD) [15][16][17], have recently been described as separate entities.…”

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confidence: 99%

Clinical and Pathological Overlap between Frontotemporal Dementia, Primary Progressive Aphasia and Corticobasal Degeneration: The Pick Complex

Kertesz

Davidson²,

Muñoz³

1999

Dement Geriatr Cogn Disord

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A substantive overlap between the clinical syndromes of frontal lobe dementia (FLD), frontotemporal dementia (FTD), or primary progressive aphasia (PPA), and corticobasal degeneration syndrome (CBDS) has been demonstrated in a population of 55 patients followed for more than 3 years in a cognitive neurology clinic. Patients presenting with the personality behavior disorder (FLD) often develop progressive aphasia (PA) and vice versa. CBDS is often associated with FLD and PA, and the extrapyramidal-apractic syndrome of CBDS often appears in FLD and PPA. The histopathological variations do not predict the clinical phenotype. The term Pick complex is suggested to indicate that these clinical and pathological variations are related and they were first described by Pick as clinical manifestations of fronotemporal atrophy. This term will avoid the confusion of using FLD or FTD or for the whole complex and also for the personality behavioral presentation. The relationship of the various clinical presentations has been strengthened by the discovery of chromosome 17 linkage in families manifesting them.

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Asymptomatic Extrapyramidal Involvement in Pick's Diease

Cited by 27 publications

References 0 publications

Distribution of basal ganglia lesions in Pick's disease with Pick bodies: A topographic neuropathological study of eight autopsy cases

Distribution of basal ganglia lesions in Pick's disease with Pick bodies: A topographic neuropathological study of eight autopsy cases

Relationship between Frontotemporal Dementia and Corticobasal Degeneration/Progressive Supranuclear Palsy

Clinical and Pathological Overlap between Frontotemporal Dementia, Primary Progressive Aphasia and Corticobasal Degeneration: The Pick Complex

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