Distribution of basal ganglia lesions in Pick's disease with Pick bodies: A topographic neuropathological study of eight autopsy cases

Abstract

The distribution of the basal ganglia lesions, including the amygdala, striatum, and pallidum, were investigated neuropathologically in eight Japanese autopsy cases of Pick's disease with Pick bodies. The lesions were classified as mild, moderate or severe. The degree and distribution of basal ganglia lesions in all eight cases were uniform: the amygdala showed severe to moderate lesions, the caudate nucleus and putamen showed moderate to mild lesions, and the pallidum showed mild lesions. Furthermore, the lesions in the amygdala were more prominent in the basolateral group than in the corticomedial group. In Pick's disease with Pick bodies, the degree and distribution of the lesions within the basal ganglia differs from those reported in both ‘Pick's disease without Pick bodies’ and corticobasal degeneration (CBD), in which severe lesions were present in the pallidum. These neuropathological findings may contribute to the morphological differential diagnosis among Pick's disease with Pick bodies, ‘Pick's disease without Pick bodies’, and CBD.

Basal ganglia lesions in ‘Pick complex’: A topographic neuropathological study of 19 autopsy cases

“…In contrast, one case of PDPB showed not only mild neuronal loss in the caudate nucleus and putamen, but also slight neuronal loss in the substantia nigra, consistent with the study investigated by Tsuchiya et al. in 1999 and 2001 5,6 . A study by Kosaka et al.…”

“…The basal ganglia lesions, featuring prominent neuronal loss in the caudate nucleus and constant involvement of the substantia nigra, in all four cases were also reported by Tsuchiya et al. 11 …”

“…The classification of basal ganglia lesions described above is fundamentally consistent with that in CBD, PDPB, gvPD, and diffuse neurofibrillary tangles with calcification, as described by Tsuchiya et al. 5,8 , 11,32 …”

Basal ganglia lesions in ‘Pick complex’: A topographic neuropathological study of 19 autopsy cases

“…In contrast, one case of PDPB showed not only mild neuronal loss in the caudate nucleus and putamen, but also slight neuronal loss in the substantia nigra, consistent with the study investigated by Tsuchiya et al. in 1999 and 2001 5,6 . A study by Kosaka et al.…”

“…The basal ganglia lesions, featuring prominent neuronal loss in the caudate nucleus and constant involvement of the substantia nigra, in all four cases were also reported by Tsuchiya et al. 11 …”

“…The classification of basal ganglia lesions described above is fundamentally consistent with that in CBD, PDPB, gvPD, and diffuse neurofibrillary tangles with calcification, as described by Tsuchiya et al. 5,8 , 11,32 …”

Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases

“…4); or severe, pronounced neuronal loss with rarefaction of the neuropil and/or prominent fibrillary gliosis (Fig. The classifi-cation of basal ganglia lesions described above, except for lesions of the substantia nigra, is fundamentally consistent with the classification of basal ganglia lesions in CBD and PDPB, as described by Tsuchiya et al [20,22], respectively. Substantia nigra lesions were judged compared with normal controls (Fig.…”

An autopsy case of frontotemporal dementia with severe dysarthria and motor neuron disease showing numerous basophilic inclusions

“…So far, adult‐onset cases showing basophilic inclusions consist of two major subgroups: 14 one is a generalized variant of Pick’s disease or relatively early onset FTD, 15 and the other is motor neuron disease with basophilic inclusions. Although only a few cases in each subgroup have been reported, 8,15–18 some of these cases show a widespread distribution of lesions as was observed in our case.…”

Basal ganglia lesions in ‘Pick complex’: A topographic neuropathological study of 19 autopsy cases

“…In contrast, one case of PDPB showed not only mild neuronal loss in the caudate nucleus and putamen, but also slight neuronal loss in the substantia nigra, consistent with the study investigated by Tsuchiya et al. in 1999 and 2001 5,6 . A study by Kosaka et al.…”

“…The basal ganglia lesions, featuring prominent neuronal loss in the caudate nucleus and constant involvement of the substantia nigra, in all four cases were also reported by Tsuchiya et al. 11 …”

“…The classification of basal ganglia lesions described above is fundamentally consistent with that in CBD, PDPB, gvPD, and diffuse neurofibrillary tangles with calcification, as described by Tsuchiya et al. 5,8 , 11,32 …”

Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases

“…4); or severe, pronounced neuronal loss with rarefaction of the neuropil and/or prominent fibrillary gliosis (Fig. The classifi-cation of basal ganglia lesions described above, except for lesions of the substantia nigra, is fundamentally consistent with the classification of basal ganglia lesions in CBD and PDPB, as described by Tsuchiya et al [20,22], respectively. Substantia nigra lesions were judged compared with normal controls (Fig.…”

An autopsy case of frontotemporal dementia with severe dysarthria and motor neuron disease showing numerous basophilic inclusions

“…So far, adult‐onset cases showing basophilic inclusions consist of two major subgroups: 14 one is a generalized variant of Pick’s disease or relatively early onset FTD, 15 and the other is motor neuron disease with basophilic inclusions. Although only a few cases in each subgroup have been reported, 8,15–18 some of these cases show a widespread distribution of lesions as was observed in our case.…”

Basal ganglia lesions in ‘Pick complex’: A topographic neuropathological study of 19 autopsy cases

“…In contrast, one case of PDPB showed not only mild neuronal loss in the caudate nucleus and putamen, but also slight neuronal loss in the substantia nigra, consistent with the study investigated by Tsuchiya et al. in 1999 and 2001 5,6 . A study by Kosaka et al.…”

“…The basal ganglia lesions, featuring prominent neuronal loss in the caudate nucleus and constant involvement of the substantia nigra, in all four cases were also reported by Tsuchiya et al. 11 …”

“…The classification of basal ganglia lesions described above is fundamentally consistent with that in CBD, PDPB, gvPD, and diffuse neurofibrillary tangles with calcification, as described by Tsuchiya et al. 5,8 , 11,32 …”

Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases

“…4); or severe, pronounced neuronal loss with rarefaction of the neuropil and/or prominent fibrillary gliosis (Fig. The classifi-cation of basal ganglia lesions described above, except for lesions of the substantia nigra, is fundamentally consistent with the classification of basal ganglia lesions in CBD and PDPB, as described by Tsuchiya et al [20,22], respectively. Substantia nigra lesions were judged compared with normal controls (Fig.…”

An autopsy case of frontotemporal dementia with severe dysarthria and motor neuron disease showing numerous basophilic inclusions

“…So far, adult‐onset cases showing basophilic inclusions consist of two major subgroups: 14 one is a generalized variant of Pick’s disease or relatively early onset FTD, 15 and the other is motor neuron disease with basophilic inclusions. Although only a few cases in each subgroup have been reported, 8,15–18 some of these cases show a widespread distribution of lesions as was observed in our case.…”