Asymptomatic bacteriuria and pyelonephritis during pregnancy

Набока, Ю. Л.; Рымашевский, А. Н.; Kogan, O; Гудима, И А; Воробьева, Н. В.; Алькина, А. К.

doi:10.21886/2219-8075-2021-12-3-22-31

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…Another main cause of UTIs in married pregnant women is that having sex during pregnancy increases the chance that a woman may have urinary tract infections [4]. Major risk factors for UTIs include diabetes, anemia, poor personal cleanliness, and a history of UTIs [5]. Raises the possibility of an upper UTIs as a result of physiological alterations.…”

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confidence: 99%

Serological diagnosis of IL-1β and IL-6 associated with Urinary tract infections among pregnant women in Thi-Qar Governorate

Farhood,

Hamim,

Shakir

2024

UTJsci

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Urinary tract infections (UTIs) are considered the most prevalent infectious disorders. They can affect the entire urinary tract or specific a portion of it and are mostly brought on by bacteria that are found in the intestine. The present study included 82 pregnant women whom age ranged from 17 to 40 (mean ± SD: 27.44 ± 6.66) and divided to 13 in the first trimester, 9 in the second, and 60 in the third. Also, the study included 56 apparently healthy pregnant women as a control, with age (mean ± SD: 27.11 ± 5.59). Patients with UTIs had lower mean serum levels of IL-6 (12.08 ±16.35 pg/ml) compared to control group (42.19 ± 28.0 pg/ml). Also, the same patients showed had lower mean serum levels of IL-1β (6.91 ± 11.78 pg/ml) compared to control group (43.32 ± 34.62 pg/ml). The conclusions, UTIs continues to be one the most socio-health problems that need a lot of care diagnosis and treatment. Both IL-6 and IL-1β in UTIs pregnant women identification may contribute as Diagnostic marker tools for associated infections.

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Section: Introductionmentioning

confidence: 99%

Serological diagnosis of IL-1β and IL-6 associated with Urinary tract infections among pregnant women in Thi-Qar Governorate

Farhood,

Hamim,

Shakir

2024

UTJsci

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Urinary tract infections in pregnant women

Degtyareva,

Romanova

2024

Medicinskij sovet

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Urinary tract infections (UTIs) are the most common pathology among pregnant women and are associated with maternal and foetal complications. According to some authors, the incidence of UTIs increased 4 times in the last decades of the 20th century. Escherichia coli is the most predominant pathogen causing up to 80% of UTIs, Klebsiella is ranked second causing up to 8% of UTIs, and pathogenic staphylococcus and mixed microflora are ranked third. To diagnose UTIs, laboratory, physical and radiological diagnostic methods are applied. According to most authors, informative value yielded by lab tests is more than 90%. The prescription of antibacterial chemotherapy should be based on the results of urine culture and sensitivity testing. Before the test results are obtained, broad-spectrum antibacterial drugs (ABs) are usually prescribed. The most commonly used therapy regimens are third-generation cephalosporins with dose adjustments, as may be necessary, after sensitivity is determined. Some authors recommend to continue treatment with urinary tract antiseptics after AB therapy is completed. The impaired urine output should be restored before AB therapy is prescribed. This review presents an analysis of the literature that was found in the databases PubMed (the National Library of Medicine), The Cochrane Library, as well as in the research citation databases (Scopus, Web of Science). The etiological factors and features of the pathogenesis of UTIs in pregnant women, as well as diagnostic standards, are described. The current guidelines for the treatment and prevention of UTIs in pregnant women are considered and antibacterial therapy regimens with current dosage forms are presented. The benefits of using cefixime dispersible forms are described in detail.

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Comparative analysis of the effectiveness of antibiotic therapy and combined administration of antibiotics, lactobacilli, and proanthocyanidins for asymptomatic bacteriuria in young pregnant women: A randomized prospective study

Sakhautdinova,

Sitdikova,

Fatkullina

2024

Kuban. nauсh. med. vestnik

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Background. Asymptomatic bacteriuria in pregnant women is not accompanied by visible symptoms; however, it involves the risk of serious complications, including gestational pyelonephritis and/or preterm labor, thereby threatening the health of both mother and child. This condition raises particular concern in light of the growing global problem of antibiotic resistance causing traditional therapies to be less effective or futile. Therefore, a study into alternative medicine approaches to asymptomatic bacteriuria in pregnant women appears highly relevant in terms of developing new solutions for managing this condition while minimizing maternal and child health risks and preventing the spread of antibiotic resistance.Objectives. To conduct a comparative analysis of the effectiveness of antibiotic therapy and combined administration of antibiotics, lactobacilli, and proanthocyanidins for asymptomatic bacteriuria in young pregnant women.Methods. 50 pregnant women aged 15 to 17 and diagnosed with asymptomatic bacteriuria participated in a randomized prospective study. Patients were randomly divided into two groups depending on the treatment. Group 1 received standard antibiotic therapy; group 2 received a combination of antibiotics with lactobacilli and proanthocyanidins. Treatment was carried out in the Republican Clinical Perinatal Center, the Republic of Bashkortostan. Patients were enrolled in the study from February 2021 to January 2022. The observation period included several stages: 10 days after treatment (first control), 30 days after treatment (second control), and 2 months after delivery (final control). The condition of the urinary tract was assessed depending on bacterial concentration, with the diagnosis of asymptomatic bacteriuria being made in case of a 105 CFE/mL (colony forming units of bacteria per milliliter of urine). The endpoint of the study was considered to be the cure of pregnant women from asymptomatic bacteriuria, which was determined by the absence of bacteria in the urine 10 days after the therapy, as well as a recurrence-free period for two months after delivery. Statistical data processing was carried out using Statistica 10.0 (StatSoft, USA) for Windows and Microsoft Excel (Microsoft, USA). A statistical level with p ≤ 0.05 was considered significant.Results. Treatment outcomes showed a significant reduction in bacteriuria and recurrent infection, especially in the group receiving the combined therapy. No bacteriuria was reported in 36 % of patients in group 1 and 76 % in group 2 (Yates’ chi-squared test, p = 0.011). The incidence of preterm labor appeared lower in the combined therapy group (4 % for group 2 and 12 % for group 1). Complications were recorded in 11 young pregnant women of group 1 (44 %) and in 3 women of group 2 (12 %). Statistical analysis indicated significant differences between the groups in terms of complication rate after treatment (Fisher’s exact test, p = 0.015).Conclusion. Combined therapy including antibiotics, lactobacilli, and proanthocyanidins demonstrates high effectiveness as an alternative to conventional treatments of asymptomatic bacteriuria in pregnant women. Due to this approach, bacteriuria as well as recurrence rate decreases, thereby contributing to a more stable health status.

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Asymptomatic bacteriuria and pyelonephritis during pregnancy

Cited by 4 publications

References 40 publications

Serological diagnosis of IL-1β and IL-6 associated with Urinary tract infections among pregnant women in Thi-Qar Governorate

Serological diagnosis of IL-1β and IL-6 associated with Urinary tract infections among pregnant women in Thi-Qar Governorate

Urinary tract infections in pregnant women

Comparative analysis of the effectiveness of antibiotic therapy and combined administration of antibiotics, lactobacilli, and proanthocyanidins for asymptomatic bacteriuria in young pregnant women: A randomized prospective study

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