Asymmetrical flow field-flow fractionation coupled to inductively coupled plasma mass spectrometry for sizing SeNPs for packaging applications

Palomo-Siguero, María; Vera, Paula; Echegoyen, Yolanda; Nerín, Cristina; Cámara, Carmen; Madrid, Yolanda

doi:10.1016/j.sab.2017.03.019

Cited by 14 publications

(4 citation statements)

References 16 publications

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“…Several parameters, such as the metal salt concentration, the use of suitable reducing agents, temperature, pH and reaction time, are critical to obtain high yields and purities in the synthesis of SeNPs [13]. Different strategies in the synthesis of SeNPs involve the use of ascorbic acid [14] or polyphenols derived from plants [15] as reducing agents. However, SeNPs obtained in that way show some limitations, such as their poor stability, so the addition of stabilizing agents during synthesis becomes necessary.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Green Synthesis and Antioxidant Activity of Selenium Nanoparticles Using Theobroma cacao L. Bean Shell Extract

2019

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Selenium nanoparticles (SeNPs) are successfully synthesized through microwave heating by using Theobroma cacao L. bean shell extract as a stabilizing and capping agent. Response surface methodology is used to obtain optimal synthesis conditions. The effect of microwave power, irradiation time and amount of Na2SeO3 are evaluated on crystalline size by X-Ray Diffraction (XRD) and Z-potential by Dynamic Light Scattering (DLS) using a central composite design (CCD). Optimal synthesis conditions are determined as 15.6 min, 788.6 W and 0.14 g of sodium selenite using 50 mL of Theobroma cacao L. bean shell extract. The successful biosynthesis of SeNPs is confirmed by UV-visible and Fourier Transformed Infrared (FTIR) spectroscopic analyses. The XRD pattern and Raman spectra show the presence of trigonal and amorphous synthesized SeNPs. Spherical SeNPs are observed by Transmission Electron Microscopy (TEM) with a particle size of 1–3 nm in diameter, at least one order of magnitude lower than those previously reported. The obtained SeNPs can be stable up to 55 days at 4 °C. Additionally, the SeNPs show an excellent antioxidant performance by the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and ferric reducing antioxidant power (FRAP) methods, with potential application in different sectors, such as food, medical and pharmaceutical.

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Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Green Synthesis and Antioxidant Activity of Selenium Nanoparticles Using Theobroma cacao L. Bean Shell Extract

2019

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“…Several alternative methods were already developed or classical methods for selenium were adapted to NPs. Recently, alternatives to TEM, such as (a)symmetrical flow field-flow fractionation (FFF), coupled with different detectors [ 237 , 238 ], or single-particle inductively coupled plasma mass spectrometry (SP-ICP-MS) [ 39 ], were proposed for detecting and characterizing SeNPs. Asymmetrical flow field-flow fractionation (AF4) coupled with a matrix diode array detector (DAD) and ICP-MS (AF4–UV-ICP-MS) was developed and applied for characterization and size determination of SeNPs synthesized by reducing selenite with ascorbic acid in the presence of stabilizers such as polysaccharides (chitosan (poly ( d -glucosamine) and hydroxyethylcellulose (HEC)).…”

Section: Analytical Methods For Selenium Detection and Speciationmentioning

confidence: 99%

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

Constantinescu-Aruxandei

Frîncu

Capră

et al. 2018

Nutrients

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Selenium is essential for humans and the deficit of Se requires supplementation. In addition to traditional forms such as Se salts, amino acids, or selenium-enriched yeast supplements, next-generation selenium supplements, with lower risk for excess supplementation, are emerging. These are based on selenium forms with lower toxicity, higher bioavailability, and controlled release, such as zerovalent selenium nanoparticles (SeNPs) and selenized polysaccharides (SPs). This article aims to focus on the existing analytical systems for the next-generation Se dietary supplement, providing, at the same time, an overview of the analytical methods available for the traditional forms. The next-generation dietary supplements are evaluated in comparison with the conventional/traditional ones, as well as the analysis and speciation methods that are suitable to reveal which Se forms and species are present in a dietary supplement. Knowledge gaps and further research potential in this field are highlighted. The review indicates that the methods of analysis of next-generation selenium supplements should include a step related to chemical species separation. Such a step would allow a proper characterization of the selenium forms/species, including molecular mass/dimension, and substantiates the marketing claims related to the main advantages of these new selenium ingredients.

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“…1 Selenium nanoparticles (SeNPs) have gained attention due to their functions of having anticancer, 2 and antimicrobial properties, 3 as dietary supplements, 4 and in food packaging. 5 The synthesis and characterization of various functional inorganic nanoparticles by different techniques to provide chemical composition, morphology, and size have been reported in the literature. [6][7][8][9][10] According to the European Commission, not only the size of particles but also the size distribution should be considered when dealing with the hazard or risk of nanomaterials to human health and environment.…”

Section: Introductionmentioning

confidence: 99%

Use of flow field-flow fractionation and single particle inductively coupled plasma mass spectrometry for size determination of selenium nanoparticles in a mixture

2020

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Various analytical techniques have been used for size analysis of selenium nanoparticles (SeNPs). These include flow field-flow fractionation (FlFFF), single particle inductively coupled plasma mass spectrometry (SP-ICP-MS), dynamic light scattering (DLS) and transmission electron microscopy (TEM).For hydrodynamic diameter estimation, the FlFFF technique was used and the results were compared with those analyzed by DLS. For core diameter estimation, the results obtained from SP-ICP-MS were compared with those from TEM. Two types of FlFFF channel were employed, i.e., symmetrical FlFFF (Sy-FlFFF) and asymmetrical FlFFF (Asy-FlFFF). Considering the use of FlFFF, optimization was performed on a Sy-FlFFF channel to select the most appropriate carrier liquid and membrane in order to minimize problems due to particle membrane interaction. The use of FL-70 and 10 kDa RC provided an acceptable compromise peak quality and size accuracy for all samples of SeNPs which were coated by proteins (positively charged SeNPs) and sodium dodecyl sulfate (negatively charged SeNPs). FlFFF always yielded the lower estimate of the hydrodynamic size than DLS as a reference method. The results obtained by SP-ICP-MS were consistent with the TEM method for the core diameter estimation. The results from FlFFF and the DLS reference method were significantly different as confirmed by paired ttest analysis, while the results provided by SP-ICP-MS and the TEM reference method were not significantly different. Furthermore, consecutive size analysis by SP-ICP-MS for the fractions collected from FlFFF was proposed for sizing of SeNP mixtures. The combined technique helps to improve the size analysis in the complex samples and shows more advantages than using only SP-ICP-MS.

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Asymmetrical flow field-flow fractionation coupled to inductively coupled plasma mass spectrometry for sizing SeNPs for packaging applications

Cited by 14 publications

References 16 publications

Microwave-Assisted Green Synthesis and Antioxidant Activity of Selenium Nanoparticles Using Theobroma cacao L. Bean Shell Extract

Microwave-Assisted Green Synthesis and Antioxidant Activity of Selenium Nanoparticles Using Theobroma cacao L. Bean Shell Extract

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

Use of flow field-flow fractionation and single particle inductively coupled plasma mass spectrometry for size determination of selenium nanoparticles in a mixture

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