Asymmetric synthesis, biological activity and molecular docking studies of some unsaturated α-amino acids, derivatives of glycine, allylglycine and propargylglycine

Mkrtchyan, Anna F.; Saghyan, Ashot S.; Hayriyan, Liana A.; Sargsyan, A. A.; Karapetyan, Ani J.; Tovmasyan, Anna S.; Tsaturyan, Avetis H.; Minasyan, Ella V.; Poghosyan, Artavazd S.; Paloyan, Ani M.; Panosyan, G. A.; Sahakyan, Lusine

doi:10.1016/j.molstruc.2020.127850

Cited by 12 publications

(3 citation statements)

References 19 publications

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“…In this regard, we would like to stress the growing need in availability and affordability of various tactual types of AAs. Indeed, the interest in the development of synthetic approaches for the preparation of tailor‐made AAs in enantiomerically pure form is currently at an all‐time high 82–135 . Some impressive developments have been made in the area of dynamic kinetic resolution of unprotected AAs, 136–139 a methodology which is best suited for large‐scale production and can rival biocatalytic approaches in affordability and low‐cost structure.…”

Section: Discussionmentioning

confidence: 99%

New pharmaceuticals approved by FDA in 2020: Small‐molecule drugs derived from amino acids and related compounds

et al. 2021

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Section: Discussionmentioning

confidence: 99%

New pharmaceuticals approved by FDA in 2020: Small‐molecule drugs derived from amino acids and related compounds

et al. 2021

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“…Even far greater role AAs play in bio‐pharmaceuticals such as peptides, peptidomimetics and proteins [3] . Accordingly, interest in the development of synthetic approaches for the preparation of tailor‐made AAs and their derivatives is currently at an all‐time high [4–21] …”

Section: Introductionmentioning

confidence: 99%

Tailor‐Made Amino Acids in Pharmaceutical Industry: Synthetic Approaches to Aza‐Tryptophan Derivatives

Han

Lyutenko

Sorochinsky

et al. 2021

Chemistry A European J

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Over the recent years there has been a noticeable upsurge of interest in aza‐analogs of tryptophan which are isosteric to the latter and found numerous applications in medicinal, bioorganic chemistry, and peptide research. In the present review article, five aza‐tryptophan derivatives are profiled, including aza‐substitution in the positions 2, on the five‐membered ring, as well as in positions 4, 5, 6, and 7 on the six‐membered ring. A detailed and comprehensive literature overview of the synthetic methods for the preparation of these aza‐tryptophans is presented and general facets of the biological properties and most promising applications are discussed.

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“…Materials and Methods. Non-protein amino acids and peptides used in this study were synthesized at the Scientific and Production Center "Armbiotechnology" NAS RA and Institute of Pharmacy of Yerevan State University [4][5][6][7]. Collagenase G from Clostridium (Hathewaya) histolyticum (EC 3.4.24.3) and miscellaneous reagents were purchased from "Sigma-Aldrich" (now "Merck").…”

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confidence: 99%

The Influence of Non-Protein Amino Acids and Peptides on Bacterial Collagenase

Sargsyan

Karapetyan

Hayriyan

et al. 2022

Proc. YSU B: Chem. Biol. Sci.

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Bacterial collagenolytic proteases have drawn increasing attention due to their essential role in the global nitrogen cycling and their virulent role in some diseases. The inhibition of these enzymes is attractive, as it does not attack the pathogen directly but rather blocks the colonization and infiltration of the host by the clostridia. Optically active non-protein α-amino acids have been screened for their ability to inhibit collagenase of Clostridium histolyticum. Both structure-based drug design approach (modeling) and that of determining enzyme activity in the presence of amino acids have been used to identify low molecular weight inhibitors of collagenase. The compounds able to inhibit collagenase activity have been revealed and IC50 values have been estimated.

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Asymmetric synthesis, biological activity and molecular docking studies of some unsaturated α-amino acids, derivatives of glycine, allylglycine and propargylglycine

Cited by 12 publications

References 19 publications

New pharmaceuticals approved by FDA in 2020: Small‐molecule drugs derived from amino acids and related compounds

New pharmaceuticals approved by FDA in 2020: Small‐molecule drugs derived from amino acids and related compounds

Tailor‐Made Amino Acids in Pharmaceutical Industry: Synthetic Approaches to Aza‐Tryptophan Derivatives

The Influence of Non-Protein Amino Acids and Peptides on Bacterial Collagenase

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