Tailor-made amino acids are indispensable structural components of modern medicinal chemistry and drug design. Consequently, stereo-controlled preparation of amino acids is the area of high research activity. Over last decade, application of Ni(II) complexes of Schiff bases derived from glycine and chiral tridentate ligands has emerged as a leading methodology for the synthesis of various structural types of amino acids. This review article summarizes examples of asymmetric synthesis of tailor-made α-amino acids via the corresponding Ni(II) complexes, reported in the literature over the last four years. A general overview of this methodology is provided, with the emphasis given to practicality, scalability, cost-structure and recyclability of the chiral tridentate ligands.

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Motivated by measurements on stretched double-stranded DNA in the presence of multivalent cations, we develop a statistical mechanical model for the compaction of an insoluble semiflexible polymer under tension. Using a mean-field approach, we determine the order of the extended-to-compact transition and provide an interpretation for the magnitude and interval of tensions over which compaction takes place. In the simplest thermodynamic limit of an infinitely long homogeneous polymer, compaction is a first-order transition that occurs at a single value of tension. For finite length chains or for heterogeneous polymers, the transition progresses over an interval of tension. Our theory provides an interpretation for the result of single-molecule experiments in terms of microscopic parameters such as persistence length and free energy of condensation.

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Tissue topology, in particular proliferating epithelium topology, is remarkably similar between various species. Understanding the mechanisms that result in the observed topologies is needed for better insight into the processes governing tissue formation. We present a two-dimensional single-cell based model for cell divisions and tissue growth. The model accounts for cell mechanics and allows cell migration. Cells do not have pre-existing shapes or topologies. Shape changes and local rearrangements occur naturally as a response to the evolving cellular environment and cell-cell interactions. We show that the commonly observed tissue topologies arise spontaneously from this model. We consider different cellular rearrangements that accompany tissue growth and study their effects on tissue topology.

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