Asymmetric Reactions of N-Phosphonyl/Phosphoryl Imines

Abstract

The asymmetric reactions of imines continued to attract the attention of the scientific community for decades. However, the stereoselective reactions of N-phosphonyl/phosphoryl imines remained less explored as compared to other N-substituted imines. The chiral auxiliary-based asymmetric-induction strategy with N-phosphonyl imines could effectively generate enantio- and diastereomeric amine, α,β-diamine, and other products through various reactions. On the other hand, the asymmetric approach for the generation of chirality through the utilization of optically active ligands, along with metal catalysts, could be successfully implemented on N-phosphonyl/phosphoryl imines to access numerous synthetically challenging chiral amine scaffolds. The current review critically summarizes and reveals the literature precedence of more than a decade to highlight the major achievements existing to date that can display a clear picture of advancement as well drawbacks in this area.

Mechanism of photocatalyzed imine conversion: a relay process of sequential energy transfer, single electron transfer and proton transfer

“…Imine building blocks have been a staple in organic synthetic chemistry for decades. 1–9 Imine compounds have the ability to synthesize a wide range of products that exhibit notable pharmacophysiological activities, 2,10–13 including antibacterial, antitumor, antiviral, and anti-inflammatory properties. 14–18 However, traditional conversion of imines requires a two-electron process that often necessitates the use of organometallic reagents, special additives, and critical conditions.…”