Asymmetric membrane capsules for osmotic drug delivery II. In vitro and in vivo drug release performance

Thombre, Avinash G.; Cardinal, John R.; DeNoto, A.R.; Gibbes, D.C.

doi:10.1016/s0168-3659(98)00101-1

Cited by 60 publications

(15 citation statements)

References 5 publications

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“…After quenching the pins were withdrawn and allowed to air dry for 4 h then the capsule shells were stripped off from the molds, trimmed to the required size and stored in a desiccator until further use. [10][11][12][13][14] In the semi-automatic process same manufacturing procedure was followed using fabricated equipment by dipping the teflon mold containing cap and body hood dipped into the polymer solution followed by spinning. Then the molds were taken out by moving the horizontal arm in the upward direction and inverted for 30 s for initial drying and then the mold plate was dipped into the quench bath containing 5% v/v aqueous PG for 3 min.…”

Section: Development Of Manual and Semi-automatic Methods For Manufactmentioning

confidence: 99%

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

Srinivasan¹,

Deveswaran²,

Veerbadraiah³

et al. 2014

Asian J Pharm

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A symmetric membrane capsules are one of the novel osmotic delivery devices which offer the delivery of a wide range of drugs in a controlled manner. In the present work, we developed a semi-automatic process by fabricating a hydraulic assisted mechanical robotic arm for the manufacturing of asymmetric membrane capsules and the process was validated in comparison with the manual procedure of manufacturing. The capsule walls were made by dip coating phase inversion process using cellulose acetate butyrate as polymer and propylene glycol as plasticizer/pore forming agent. The comparative examination of physical parameters in manual and semi-automatic process confirmed the consistency, reproducibility and efficiency of the semi-automatic process over manual procedure. The resulting asymmetric membrane wall was evaluated by scanning electron microscopy studies revealed the thin dense region supported on a thicker porous region. Fourier transform infrared studies showed phase inversion of the asymmetric membrane as compared to plain membrane. Osmotic release study and in vitro behavior was studied for controlled delivery of metformin hydrochloride as a model drug. In vitro release studies of the formulations showed that drug release was dependent on the concentration of pore forming agent, level of osmogents and independent of the media pH and agitation. The effect of the process variables on the drug release was optimized using 2 3 full factorial design and the release kinetics of the optimized formulation confirmed zero order kinetics with a controlled drug delivery of 13 h and the mechanism of drug release was found to be super case II transport.

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Section: Development Of Manual and Semi-automatic Methods For Manufactmentioning

confidence: 99%

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

Srinivasan¹,

Deveswaran²,

Veerbadraiah³

et al. 2014

Asian J Pharm

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show abstract

“…Furthermore, limited circulation in the blood, poor aqueous solubility, limited stability and nonselectivity reduce the therapeutic efficacy and limit the clinical application of anticancer drugs [3]. To solve these problems, various drug carriers such as micelles, nanogels and microcapsules have been investigated [4][5][6]. A novel type of hollow polyelectrolyte capsule fabricated via layerby-layer (LbL) self-assembly on sacrificial template particles, followed by core removal, has attracted a great deal of research attention.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of lactobionic-loaded chitosan microcapsules as potential drug carriers targeting the liver

et al. 2011

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“…The antimicrobial activity of the films has also been tested on selected gram-positive and gram-negative bacteria. Recently, different research groups showed the advantage of using asymmetric-membrane capsules and asymmetric coatings on drug tablets to control the release rate of drugs (Herbig et al, 1995;Cardinal et al, 1997;Wang et al, 1998;Thombre et al, 1999aThombre et al, , 1999bThombre et al, , 1999cLin and Ho, 2003;Prabakaran et al, 2004;Altinkaya and Yenal, 2006). However, the potential use of asymmetric and porous structures in preparing controlled release food packaging materials has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Development of cellulose acetate based antimicrobial food packaging materials for controlled release of lysozyme

Gemili

Yemenicioğlu

Altınkaya

2009

Journal of Food Engineering

182

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a b s t r a c tAntimicrobial packaging materials were obtained by incorporation of lysozyme into cellulose acetate (CA) films. In order to achieve controlled release of lysozyme, the structure of the films was changed from highly asymmetric and porous to dense by modulating the composition of the initial casting solution. The highest release rate, soluble lysozyme activity and antimicrobial activity were obtained with the film prepared from 5% CA solution including 1.5% lysozyme. Increasing CA content in the casting solution decreased the porosity of the films, hence, reduced the release rate, maximum released lysozyme activities and the antimicrobial activities of the films. In contrast, immobilized lysozyme activities and the tensile strength of the films increased. The incorporation of lysozyme did not cause significant reductions in tensile strength and elongation at break values except in films prepared with 15% CA. This study showed the good potential of asymmetric CA films to achieve controlled release in antimicrobial packaging.

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Asymmetric membrane capsules for osmotic drug delivery II. In vitro and in vivo drug release performance

Cited by 60 publications

References 5 publications

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

Fabrication of lactobionic-loaded chitosan microcapsules as potential drug carriers targeting the liver

Development of cellulose acetate based antimicrobial food packaging materials for controlled release of lysozyme

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