2016
DOI: 10.3390/bios6010001
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Asymmetric Mach–Zehnder Interferometer Based Biosensors for Aflatoxin M1 Detection

Abstract: In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si3N4 Asymmetric Mach–Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab′). We measured a best volumetric sensitivity of 104 rad/RIU, leading to a Limit of Detection below 5 × 10−7 RIU. On sensors functionalized with Fab′, we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also invest… Show more

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Cited by 60 publications
(32 citation statements)
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“…1881/2006). Although the LOD (3 ng/mL) needs to be improved in order to fit with the European regulation (maximum residue level (MRL) is 50 ng/L in milk) the study proves the great potential of an aMZI device as a miniaturised analytical tool for label-free detection of aflatoxin in milk [13]. Pagkali et al has developed a MZI immunosensor for the detection of Ochratoxin A, one of the most-abundant food-contaminating mycotoxins, with a LOD of 0.25 ng/mL.…”
Section: Interferometric Waveguide Biosensorsmentioning
confidence: 90%
“…1881/2006). Although the LOD (3 ng/mL) needs to be improved in order to fit with the European regulation (maximum residue level (MRL) is 50 ng/L in milk) the study proves the great potential of an aMZI device as a miniaturised analytical tool for label-free detection of aflatoxin in milk [13]. Pagkali et al has developed a MZI immunosensor for the detection of Ochratoxin A, one of the most-abundant food-contaminating mycotoxins, with a LOD of 0.25 ng/mL.…”
Section: Interferometric Waveguide Biosensorsmentioning
confidence: 90%
“…Industrial interest in the reaction fluctuated due to the changes in availability and price of oil. As the demands for environmentally friendly fuels are increasing, interest in FT synthesis is growing as well, and the technology gains attention to produce liquid fuels from natural gas, coal and biomass (Fechete and Vedrine, 2017;Krylova, 2014;Samavati, 2018). Bio-derived synthetic hydrocarbons from synthesis gas offers a cleaner and more sustainable solution compared to fossil alternatives, with significantly reduced greenhouse gas emissions (GHGs) and net climate impact.…”
Section: The Fischer-tropsch Process For Hydrocarbon Productionmentioning
confidence: 99%
“…In all the above reports, the MZIs were symmetric, i.e., the sensing and the reference arms had equal length; nonetheless, asymmetric MZIs with small path differences between the two arms, have been also fabricated. Such an MZI has been employed for the immunochemical detection of aflatoxin M1 (AFM1) in milk samples [89]. The sensor LOD for AFM1 was 3 mg/L, which is orders of magnitude higher than the maximum allowable limit in EU (0.05 mg/mL), thus requiring sample pre-concentration.…”
Section: Integrated Interferometersmentioning
confidence: 99%