Nanophotonic label-free biosensors for environmental monitoring

Chocarro-Ruiz, Blanca; Gavela, Adrián Fernández; Herranz, Sonia; Lechuga, Laura M.

doi:10.1016/j.copbio.2017.03.016

Cited by 84 publications

(53 citation statements)

References 65 publications

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“…Other prominent biosensors for environmental surveillance are the nanophotonic biosensors, which are devices constituted of biological receptor layers immobilized onto the core surface of a waveguide, to detect evanescent waves [31]. Their functioning mechanism is based on the exposure of the waveguide surface to the analyte, resulting in a biochemical interaction that promotes a local change in the optical properties of the waveguide transducer, which can be detected, and its amplitude is modulated by the concentration of the analyte.…”

Section: Fret Applied To Environmental Biosensingmentioning

confidence: 99%

Dynamic Luminescent Biosensors Based on Peptides for Oxygen Determination

Souza¹,

Martins²,

Colmati³

2019

Biosensors for Environmental Monitoring

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This chapter summarizes the fundamentals of biosensing techniques based on fluorescence spectroscopy and the protagonism of state-of-the-art luminescent biosensors in a wide range of scientific areas, from environmental monitoring to diagnostics and decease treatment, focusing on the paramount contribution of biosensors based on the Förster Resonance Energy Transfer (FRET) transducing mechanism. State-of-the-art FRET biosensors are specially characterized by outstanding sensitivity toward a number of environmental pollutants and dissolved oxygen in aquatic ecosystems, capable of detecting concentrations in the nano and picomolar scales. These biosensors have also been showing impressive performance over other methods in the study of real-time biological processes in vivo relevant to help understanding decease progression like cancer.

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Section: Fret Applied To Environmental Biosensingmentioning

confidence: 99%

Dynamic Luminescent Biosensors Based on Peptides for Oxygen Determination

Souza¹,

Martins²,

Colmati³

2019

Biosensors for Environmental Monitoring

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“…In addition to the several research set-ups, the company Microvacuum Ltd. (http://www.owls-sensors.com/) commercializes instruments based on the grating coupler principle called Optical Waveguide Lightmode Spectroscopy (OWLS). OWLS immunosensors have been employed for the detection of pesticides, mycotoxins, and bacteria, while using cells as binders the detection of antibiotics and pesticides has been also reported [32].…”

Section: Grating-coupled Waveguide Sensorsmentioning

confidence: 99%

Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers

Angelopoulou¹,

Kakabakos²,

Petrou³

2018

Preprint

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The article reviews the current status of label-free integrated optical sensors focusing on the evolution over the years of their analytical performance. At first a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical sensors including sensors based on surface plasmon resonance (SPR), grating coupler, photonic crystals, ring resonators and interferometric transducers. After a short reference to SPR techniques, including localized SPR, integrated optical sensors i.e., grating-couplers, interferometers, photonic crystals, microring resonators are reviewed. For each type of sensor, the detection principle is first provided followed by description of the different transducer configurations so far developed and their performance as biosensors. Finally, a short discussion about the current limitations and future perspectives of integrated label-free biosensors optical sensors is provided

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“…[ 14 ] These sensing techniques reveal potential applications not only in medical diagnostics but also in drug discovery, [ 15 ] food safety, [ 16,17 ] and environmental monitoring. [ 18 ]…”

Section: Introductionmentioning

confidence: 99%

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Wang

Sánchez

Yin

et al. 2020

Adv Materials Technologies

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By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation lab‐on‐a‐chip bioanalytical systems with a great potential for point‐of‐care medical diagnostics. Herein, an overview of the latest advances in silicon‐based integrated optofluidic label‐free biosensing technologies relying on the efficient interactions between the evanescent light field at the functionalized surface and specifically bound analytes is presented. State‐of‐the‐art technologies demonstrating label‐free evanescent wave‐based biomarker detection mainly encompass three device configurations, including on‐chip waveguide‐based interferometers, microring resonators, and photonic‐crystal‐based cavities. Moreover, up‐to‐date strategies for elevating the sensitivities and also simplifying the sensing processes are discussed. Emerging laboratory prototypes with advanced integration and packaging schemes incorporating automatic microfluidic components or on‐chip optoelectronic devices lead to one significant step forward in real applications of decentralized diagnostics. Besides, particular attention is paid to currently commercialized label‐free optical bioanalytical models on the market. Finally, the prospects are elaborated with several research routes toward chip‐scale, low‐cost, highly sensitive, multi‐functional, and user‐friendly bioanalytical systems benefiting to global healthcare.

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Nanophotonic label-free biosensors for environmental monitoring

Cited by 84 publications

References 65 publications

Dynamic Luminescent Biosensors Based on Peptides for Oxygen Determination

Dynamic Luminescent Biosensors Based on Peptides for Oxygen Determination

Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

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