Asymmetric composite wound nanodressing with superhydrophilic/superhydrophobic alternate pattern for reducing blood loss and adhesion

Long, Cai; Qing, Yongquan; Li, Songhe; Cui, Miao; Han, Mengxue; An, Kai; Xiao, Long; Liu, Chen; Liu, Changsheng

doi:10.1016/j.compositesb.2021.109134

Cited by 31 publications

(8 citation statements)

References 77 publications

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“…Wound infection and excessive biological fluids (e.g., bleeding and exudate.) can affect one or more factors in the process of wound healing, which can ultimately affect wound healing (Long et al, 2021;Xu et al, 2021). Currently, the primary clinical anti-infection treatment is through oral antibiotics.…”

Section: Introductionmentioning

confidence: 99%

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

Zhao

Xu²,

Wang³

et al. 2022

Front. Bioeng. Biotechnol.

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Wound infection and excessive exudate can affect the process of wound healing. However, the disadvantage of the anti-microbial wound dressings is that the biological fluids are ineffectively removed. Inspired by making “Chinese Jianbing”, a composite wound nano-dressing was developed consisting of a hydrophilic outer layer (chitosan&polyvinyl alcohol: CTS-PVA) and a hydrophobic inner layer (propolis&polycaprolactone: PRO-PCL) by combining casting and electrospinning methods for effective antibacterial and unidirectional removing excess biofluids. In vitro, the composite wound nano-dressing of PRO-PCL and CTS-PVA (PPCP) could strongly inhibit Pseudomonas aeruginosa. Furthermore, PPCP wound dressing had excellent antioxidant properties and blood coagulation index for effective hemostatic. Importantly, it had a preferable water absorption for removing excess biofluid. In vivo, it had anti-inflammatory properties and promoted collagen Ⅰ preparation, which realized 80% wound healing on day 7. In short, the PPCP wound dressing provides a new direction and option for antibacterial and removes excess biofluid.

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Section: Introductionmentioning

confidence: 99%

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

Zhao

Xu²,

Wang³

et al. 2022

Front. Bioeng. Biotechnol.

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“…On the same surface, CAs gradually increased from water to blood droplets, which is consistent with the findings from previous studies. 31,32 This phenomenon could be caused by surface tension, which originated from intermolecular attraction (Figure 3d). At the solid−liquid contact interface, the resultant force of liquid surface tension (γ l ) and solid−liquid interface tension (γ sl ) faced the interior of the droplet.…”

Section: Wettability Characterizationmentioning

confidence: 99%

Synergetic Effects of Nanoscale ALD–HfO₂ Coatings and Bionic Microstructures for Antiadhesive Surgical Electrodes: Improved Cutting Performance, Antibacterial Property, and Biocompatibility

Li,

Xie,

Yang

et al. 2023

ACS Appl. Mater. Interfaces

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The high temperature induced by surgical electrodes is highly susceptible to severe surface adhesion and thermal damage to adjacent tissues, which is a major challenge in improving the quality of electrosurgery. Herein, we reported a coupled electrode with micro/nano hierarchical structures fabricated by depositing nanoscale hafnium oxide (HfO 2 ) coatings on bionic microstructures (BMs) via laser texturing, acid washing, and atomic layer deposition (ALD) techniques. The synergistic effect of HfO 2 coatings and BMs greatly enhanced the hemophobicity of the electrode with a blood contact angle of 162.15 ± 3.16°. Furthermore, the coupled surface was proven to have excellent antiadhesive properties to blood when heated above 100 °C, and the underlying mechanism was discussed. Further experiments showed that the coupled electrode had significant advantages in reducing cutting forces, thermal damage, and tissue adhesion mass. Moreover, the antibacterial rates against Escherichia coli and Staphylococcus aureus were 97.2% and 97.9%, respectively. In addition, the noncytotoxicity levels of HfO 2 coatings were verified by cell apoptosis and cycle assays, indirectly endowing the coupled electrode with biocompatibility. Overall, the coupled electrode was shown to have broad potential for application in the field of electrosurgery, and this work could provide new insights into antiadhesion properties under high-temperature conditions.

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“…The adhesion/blocking effect of catechol groups, blood wicking of cotton and hydrophobic effect of alkyl chains conjointly contributed to the outstanding hemostatic efficiency (rapid hemostatic, low blood loss and no secondary injuries). Following the similar idea, superhydrophilic/superhydrophobic alternate pattern was designed to realize the balance between hemostatic and reduced adhesion ( Long et al, 2021 ).…”

Section: Superwettable Hemostatic Bio-interfacesmentioning

confidence: 99%

Recent advancements in wound management: Tailoring superwettable bio-interfaces

Dong-sheng

Xin

et al. 2022

Front. Bioeng. Biotechnol.

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Skin tissue suffering from severe damages fail in self-regeneration. Proper wound dressings are highly demanded to protect the wound region and accelerate the healing process. Although large efforts have been devoted, there still exist disturbing dilemmas for traditional dressings. The exquisite design of bio-interface upon superwettable materials opens new avenues and addresses the problems perfectly. However, the advancements in this area have rarely been combed. In light of this, this minireview attempts to summarize recent strategies of superwettable bio-interfaces for wound care. Concentrating on the management of biofluids (blood and exudate), we described superwettable hemostatic bio-interfaces first, and then introduced the management of exudates. Finally, the perspective of this area was given. This minireview gives a comprehensive outline for readers and is believed to provide references for the design of superwettable materials in biomedical area.

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Asymmetric composite wound nanodressing with superhydrophilic/superhydrophobic alternate pattern for reducing blood loss and adhesion

Cited by 31 publications

References 77 publications

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

Synergetic Effects of Nanoscale ALD–HfO₂ Coatings and Bionic Microstructures for Antiadhesive Surgical Electrodes: Improved Cutting Performance, Antibacterial Property, and Biocompatibility

Recent advancements in wound management: Tailoring superwettable bio-interfaces

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Asymmetric composite wound nanodressing with superhydrophilic/superhydrophobic alternate pattern for reducing blood loss and adhesion

Cited by 31 publications

References 77 publications

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

Synergetic Effects of Nanoscale ALD–HfO2 Coatings and Bionic Microstructures for Antiadhesive Surgical Electrodes: Improved Cutting Performance, Antibacterial Property, and Biocompatibility

Recent advancements in wound management: Tailoring superwettable bio-interfaces

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Product

Resources

About

Synergetic Effects of Nanoscale ALD–HfO₂ Coatings and Bionic Microstructures for Antiadhesive Surgical Electrodes: Improved Cutting Performance, Antibacterial Property, and Biocompatibility