Astrovirus epidemiologically linked to pre-weaning diarrhoea in mink

Englund, Lena; Chriél, Mariann; Dietz, H. H.; Hedlund, Kjell‐Olof

doi:10.1016/s0378-1135(01)00472-2

Cited by 75 publications

(85 citation statements)

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“…Several reports showed that astroviruses are present worldwide and represent the second most important cause of gastroenteritis in children, after rotaviruses (Herrmann et al, 1991;Matsui et al, 2001;Moser and Schultz-Cherry 2005;De Benedictis et al, 2011). Astroviruses have also been identified in several animal species, such as cats, swine, sheep, minks, cheetahs, sea lions, bottlenose dolphins, red deer, dogs, rodents and bats (Woode and Bridger, 1978;Snodgrass et al, 1979;Gray et al, 1980;Williams, 1980;Tzipori et al, 1981;Bridger et al, 1984;Shirai et al, 1985;Woode et al, 1985;Harbour et al, 1987;Marshall et al, 1987;Vieler and Herbst, 1995;Englund et al, 2002;Lukashov and Goudsmit, 2002;Zhu et al, 2009;Blomström et al, 2010;Chu et al, 2010;Reuter et al, 2011;Tse et al, 2011). Recently, new astroviruses (MBL1 and VA1) have been identified in humans with diarrhea (Finkbeiner et al, 2008;2009a;2009b).…”

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confidence: 99%

Characterization and phylogenetic analysis of new bat astroviruses detected in Gabon, Central Africa

Rougeron¹,

Suquet²,

Gd³

et al. 2016

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Summary. -Astroviruses are emerging RNA viruses that cause enteropathogenic infections in humans and in other mammals. The identification of astroviruses in a wide range of animals highlights the zoonotic importance of these viruses. Bats can harbor many different viruses, among which some are highly pathogenic for humans (for instance, Nipah, Ebola and SARS coronavirus), and also several astroviruses. As some RNA viruses can be directly transmitted from bats to humans, it is crucial to collect data about their frequency, genetic diversity and phylogenetic characterization. In this study, we report the molecular identification of 44 new astroviruses (with a detection rate of 4.5%) in 962 apparently healthy bats that belong to five different species and that were captured in different caves in North-East Gabon, Central Africa. Our results show that bat astroviruses form a group that is genetically distinct from astroviruses infecting other mammals. Moreover, these astroviruses showed an important genetic diversity and low host restriction in bat species.

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Section: Introductionmentioning

confidence: 99%

Characterization and phylogenetic analysis of new bat astroviruses detected in Gabon, Central Africa

Rougeron¹,

Suquet²,

Gd³

et al. 2016

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“…However, later on, two genera were established based on their hosts of origin: Mamastrovirus (MAstV) and Avastrovirus (AAstV), infecting mammalian and avian species, respectively. Although initially detected in children's stool, AstVs have been found in the feces of a wide variety of mammalian species, i.e., cats (6), cattle (7), deer (8), dogs (9), mice (10), rats (11), pigs (12), sheep (13), mink (14), bats (15), cheetahs (16), rabbits (17), and even sea lions and dolphins (18), as well as in avian species, i.e., turkeys (19), chickens (20), ducks (21), pigeons (22), and guinea fowl (23) and other wild aquatic birds (24).…”

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Human Astroviruses

2014

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SUMMARY Human astroviruses (HAtVs) are positive-sense single-stranded RNA viruses that were discovered in 1975. Astroviruses infecting other species, particularly mammalian and avian, were identified and classified into the genera Mamastrovirus and Avastrovirus . Through next-generation sequencing, many new astroviruses infecting different species, including humans, have been described, and the Astroviridae family shows a high diversity and zoonotic potential. Three divergent groups of HAstVs are recognized: the classic ( MAstV 1 ), HAstV-MLB ( MAstV 6 ), and HAstV-VA/HMO ( MAstV 8 and MAstV 9 ) groups. Classic HAstVs contain 8 serotypes and account for 2 to 9% of all acute nonbacterial gastroenteritis in children worldwide. Infections are usually self-limiting but can also spread systemically and cause severe infections in immunocompromised patients. The other groups have also been identified in children with gastroenteritis, but extraintestinal pathologies have been suggested for them as well. Classic HAstVs may be grown in cells, allowing the study of their cell cycle, which is similar to that of caliciviruses. The continuous emergence of new astroviruses with a potential zoonotic transmission highlights the need to gain insights on their biology in order to prevent future health threats. This review focuses on the basic virology, pathogenesis, host response, epidemiology, diagnostic assays, and prevention strategies for HAstVs.

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“…In children, astrovirus is known to be a major cause of diarrhea, and in animals astrovirus also is associated with enteric disorders (17). Through a case-control study, mink astroviruses have been shown to be a significant risk factor for preweaning diarrhea (5), and an astrovirus detected in a mink with this disorder has been molecularly characterized (15,16).…”

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Detection of a Novel Astrovirus in Brain Tissue of Mink Suffering from Shaking Mink Syndrome by Use of Viral Metagenomics

et al. 2010

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In 2000, farmed mink kits in Denmark were affected by a neurological disorder. The characteristic clinical signs included shaking, staggering gait, and ataxia. The disease, given the name shaking mink syndrome, was reproduced by the inoculation of brain homogenate from affected mink kits into healthy ones. However, the etiology remained unknown despite intensive efforts. In this study, random amplification and large-scale sequencing were used, and an astrovirus was detected in the brain tissue of three experimentally infected mink kits. This virus also was found in the brain of three mink kits naturally displaying the disease but not in the six healthy animals investigated. The complete coding region of the detected astrovirus was sequenced and compared to those of both a mink astrovirus associated with preweaning diarrhea and to a recently discovered human astrovirus associated with a case of encephalitis in a boy with x-linked agammaglobulinemia. The identities were 80.4 and 52.3%, respectively, showing that the virus described in this study was more similar to the preweaning diarrhea mink astrovirus. For the nonstructural coding regions the sequence identity was around 90% compared to that of the astrovirus, which is associated with preweaning diarrhea in mink. The region coding for the structural protein was more diverse, showing only 67% sequence identity. This finding is of interest not only because the detected virus may be the etiological agent of the shaking mink syndrome but also because this is one of the first descriptions of an astrovirus found in the central nervous system of animals.

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Astrovirus epidemiologically linked to pre-weaning diarrhoea in mink

Cited by 75 publications

References 11 publications

Characterization and phylogenetic analysis of new bat astroviruses detected in Gabon, Central Africa

Characterization and phylogenetic analysis of new bat astroviruses detected in Gabon, Central Africa

Human Astroviruses

Detection of a Novel Astrovirus in Brain Tissue of Mink Suffering from Shaking Mink Syndrome by Use of Viral Metagenomics

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