Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway

Qin, Xiude; Hua, Jun; Lin, Songjun; Zheng, Haotao; Wang, Jianjun; Li, Wei; Ke, Jin-ju; Cai, Hao

doi:10.1016/j.bbrc.2020.07.122

Cited by 39 publications

(17 citation statements)

References 21 publications

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“…Astragalus polysaccharides (APS), a group of bioactive compounds isolated from AR, possess multifarious effects in the central nervous system, such as anti-inflammatory, antioxidant, immunomodulating properties, which entitle this group of compounds with therapeutic effects on neurodegenerative diseases, particularly AD ( Liu Z et al, 2014 ; Zhao and Dong, 2016 ; Huang et al, 2017 ; Qin et al, 2020 ; Liu X et al, 2021 ), as shown in Table 3 . However, only a small number of studies tested their efficacy in combating AD.…”

Section: Potential Mechanisms Underlying the Therapeutic Effect Of Bi...mentioning

confidence: 99%

“…However, only a small number of studies tested their efficacy in combating AD. Qin et al (2020) studied the therapeutic effect of APS on APP/ PS1 mice which exhibited increased levels of Aβ, apoptosis, and impairment in spatial learning and memory. In addition, levels of Keap1, cytoplasmic Nrf2, and MDA were dramatically increased in these mice.…”

Section: Astragalus Polysaccharidesmentioning

confidence: 99%

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Astragalus mongholicus Bunge (Fabaceae): Bioactive Compounds and Potential Therapeutic Mechanisms Against Alzheimer’s Disease

Dong

Zhang

et al. 2022

Front. Pharmacol.

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Astragalus mongholicus Bunge (Fabaceae) (also known as Astragali radix-AR), a widely used herb by Traditional Chinese Medicine practitioners, possesses a wide range of pharmacological effects, and has been used to treat Alzheimer’s disease (AD) historically. Its bioactive compounds are categorized into four families: saponins, flavonoids, polysaccharides, and others. AR’s bioactive compounds are effective in managing AD through a variety of mechanisms, including inhibiting Aβ production, aggregation and tau hyperphosphorylation, protecting neurons against oxidative stress, neuroinflammation and apoptosis, promoting neural stem cell proliferation and differentiation and ameliorating mitochondrial dysfunction. This review aims to shed light upon the chemical constituents of AR and the mechanisms underlying the therapeutic effect of each compound in manging AD. Also presented are clinical studies which reported successful management of AD with AR and other herbs. These will be helpful for drug development and clinical application of AR to treat AD.

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Section: Potential Mechanisms Underlying the Therapeutic Effect Of Bi...mentioning

confidence: 99%

Section: Astragalus Polysaccharidesmentioning

confidence: 99%

Astragalus mongholicus Bunge (Fabaceae): Bioactive Compounds and Potential Therapeutic Mechanisms Against Alzheimer’s Disease

Dong

Zhang

et al. 2022

Front. Pharmacol.

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“…Modern pharmacological studies suggest that the active ingredients of Astragalus include astragalus polysaccharide, astragalus saponins, flavonoids calycosin, 3-hydroxy-9,10-dimethoxy pterostane, and astragaloside I, III, V. Astragalus polysaccharide is the main pharmacologically active ingredient in Astragalus . Studies have reported that it can suppress mitochondrial damage-mediated apoptosis ( Gao et al, 2021b ), modulate gut microbiota ( Zhuang et al, 2021 ), enhance immune response ( Zhou et al, 2021 ), alleviate cognitive impairment and β-amyloid accumulation via Nrf2 pathway ( Qin et al, 2020 ), enhance remyelination ( Ye et al, 2021 ), inhibit the formation of cerebral thrombosis ( Sun et al, 2020 ), protect neurons, and stabilize mitochondrial in a Parkinson disease (PD) mouse model ( Liu et al, 2018 ), and thus exhibit mitochondrial and anti-aging activity ( Li et al, 2012 ).…”

Section: Pharmacological Effects On the Active Ingredients Of Buyang ...mentioning

confidence: 99%

A Review of Traditional Chinese Medicine, Buyang Huanwu Decoction for the Treatment of Cerebral Small Vessel Disease

Sun

Wang

et al. 2022

Front. Neurosci.

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Cerebral small vessel disease (CSVD) is often referred to as “collaterals disease” in traditional Chinese medicine (TCM), and commonly includes ischemic and hemorrhagic CSVD. TCM has a long history of treating CSVD and has demonstrated unique efficacy. Buyang Huanwu Decoction (BHD) is a classical TCM formula that has been used for the prevention and treatment of stroke for hundreds of years. BHD exerts its therapeutic effects on CSVD through a variety of mechanisms. In this review, the clinical and animal studies on BHD and CSVD were systematically introduced. In addition, the pharmacological mechanisms, active components, and clinical applications of BHD in the treatment of CSVD were reviewed. We believe that an in-depth understanding of BHD, its pharmacological mechanism, disease-drug interaction, and other aspects will help in laying the foundation for its development as a new therapeutic strategy for the treatment of CSVD.

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“…Astragalus polysaccharide upregulates hepcidin and reduces iron overload in mice [ 38 ]. Moreover, Astragalus polysaccharide treatment significantly reduces apoptosis, regulates oxidative stress, and upregulates GSH peroxidase activity [ 39 ]. Calycosin is an effective monomer of RAP and can protect brain nerve cells from CIRI through antioxidant, antiapoptotic, anti-inflammatory, and autophagic activities [ 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

Roots of Astragalus propinquus Schischkin Regulate Transmembrane Iron Transport and Ferroptosis to Improve Cerebral Ischemia-Reperfusion Injury

Chen

Bao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. The dried roots of the Astragalus propinquus Schischkin (RAP) plant, as a traditional Chinese medicine, has been widely used to treat stroke, cerebral ischemia, qi deficiency, and hypertension. Buyang Huanwu decoction is traditionally used to treat stroke in China for more than 200 years and has a significant effect on cerebral ischemia, and RAP is monarch medicine of Buyang Huanwu decoction. Therefore, this study was designed to observe the regulatory effect of RAP on transmembrane iron transporters and ferroptosis-related factors in cerebral ischemia-reperfusion injury (CIRI) in rats. Methods. Middle cerebral artery occlusion (MCAO) was used to block blood flow in the blood supply area of the middle cerebral artery in seventy male SD rats to induce focal CIRI to establish a rat model of CIRI. RAP was administered to explore the regulatory effect of RAP on iron transmembrane transport under the condition of CIRI. The infarct size was measured using 2,3,5-triphenyl-tetrazolium chloride (TTC) staining, the pathological structure of brain tissue was observed by HE staining, and neuronal injury was evaluated by Nissl staining after treatment. Then, changes in the iron transporters ferritin (Fn), ferritin heavy chain (FHC), ferritin light chain (FLC), transferrin (Tf), transferrin receptor (TfR), divalent metal transporter 1 (DMT1), L-type calcium channel (LTCC), transient receptor potential canonical 6 (TRPC6), and ferroportin 1 (FPN1) were observed by immunohistochemistry staining (IHC) and Western blotting. The expression of key factors of ferroptosis, including the membrane sodium-dependent cystine/glutamate antiporter System Xc− (System Xc−) light chain subunit (XCT) and heavy chain subunit (SLC3A2), glutathione peroxidase 4 (GPX4), nuclear factor erythroid 2-related factor (NRF2), heme oxygenase-1 (HO-1), and iron-responsive element-binding protein 2 (IREB2) in the brain tissues of rats was assessed by Western blotting. RAP decreased the infarct size and neuronal injury after CIRI in rats. Similarly, RAP treatment regulated the expression of iron transporters. As such, RAP was able to reduce the expression of Fn, FHC, FLC, Tf, TfR, DMT1, and TRPC6 and increase the expression of FPN1 through a Tf/TfR-independent pathway after CIRI in rats. Conclusion. RAP stimulation inhibited ferroptosis by regulating the expression of the key ferroptosis factors XCT, SLC3A2, GPX4, NRF2, HO-1, and IREB2. In conclusion, RAP regulates transmembrane iron transport and ferroptosis to improve CIRI.

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Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway

Cited by 39 publications

References 21 publications

Astragalus mongholicus Bunge (Fabaceae): Bioactive Compounds and Potential Therapeutic Mechanisms Against Alzheimer’s Disease

Astragalus mongholicus Bunge (Fabaceae): Bioactive Compounds and Potential Therapeutic Mechanisms Against Alzheimer’s Disease

A Review of Traditional Chinese Medicine, Buyang Huanwu Decoction for the Treatment of Cerebral Small Vessel Disease

Roots of Astragalus propinquus Schischkin Regulate Transmembrane Iron Transport and Ferroptosis to Improve Cerebral Ischemia-Reperfusion Injury

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