A Review of Traditional Chinese Medicine, Buyang Huanwu Decoction for the Treatment of Cerebral Small Vessel Disease

Sun, Lei; Ye, Xuhui; Wang, Linlin; Yu, Jin; Wu, Yan; Wang, Minpeng; Dai, Lei

doi:10.3389/fnins.2022.942188

Cited by 5 publications

(2 citation statements)

References 107 publications

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“…A large number of studies show that the buyang huanwu soup, ginseng injection, ginseng wheat injection, ginseng pine nourishing heart capsule, ginseng dome glucose injection, etc. are effective for the treatment of brain-heart syndrome ( Li et al, 2016 ; Liu et al, 2016 ; Yang et al, 2016 ; Ji, 2020 ; Sun et al, 2022 ), and acupuncture from traditional medicine also has a positive effect on brain-heart syndrome ( Ya-jun et al, 2020 ; Liu et al, 2022 ). It has been shown that Edaravone is a novel free radical scavenger and antioxidant that is highly effective against a variety of acute cerebrovascular diseases and protects the cardiomyocytes of stroke patients ( Jiang et al, 2016 ).…”

Section: Advances In the Treatment Of Stroke-heart Syndromementioning

confidence: 99%

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

Wang

Peng²

2022

Front. Mol. Neurosci.

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Neurocardiology is an emerging field that studies the interaction between the brain and the heart, namely the effects of heart injury on the brain and the effects of brain damage on the heart. Acute ischemic stroke has long been known to induce heart damage. Most post-stroke deaths are attributed to nerve damage, and cardiac complications are the second leading cause of death after stroke. In clinical practice, the proper interpretation and optimal treatment for the patients with heart injury complicated by acute ischemic stroke, recently described as stroke-heart syndrome (SHS), are still unclear. Here, We describe a wide range of clinical features and potential mechanisms of cardiac complications after ischemic stroke. Autonomic dysfunction, microvascular dysfunction and coronary ischemia process are interdependent and play an important role in the process of cardiac complications caused by stroke. As a unique comprehensive view, SHS can provide theoretical basis for research and clinical diagnosis and treatment.

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Section: Advances In the Treatment Of Stroke-heart Syndromementioning

confidence: 99%

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

Wang

Peng²

2022

Front. Mol. Neurosci.

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“…Emerging studies have shown that various Chinese medicinal formulas exert therapeutic effects on CSVD. [ 43 ] In vivo animal experiments and clinical case-control studies have confirmed the effectiveness of Chinese medicine in the treatment of CSVD. [ 44 ] It is believed that Chinese medicine can be used as an effective supplement to the conventional treatment of CSVD.…”

Section: Discussionmentioning

confidence: 99%

Evidence-based evaluation of adjuvant therapy with Chinese medicine for cerebral small vessel disease: A systematic review and meta-analysis

Xu,

Chen,

et al. 2023

Medicine

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Background: As the population ages, the prevalence of cerebral small vessel disease (CSVD) steadily increases, resulting in a significant economic burden on society. In East Asian nations, Chinese medicine has been used extensively to teat CSVD and has been reported to improve the cognitive function of patients. The present study aimed to comprehensively assess the efficacy and safety of Chinese medicine as adjuvant therapy for CSVD. Methods: A literature search of the CNKI, Wanfang, VIP, SinoMed, Medline, Cochrane Library, and ChiCTR databases were searched for RCTs investigating the use of TCM as an adjuvant in the treatment of CSVD, published up to July 27, 2023, was performed. Based on the Cochrane Collaboration Network bias risk assessment criteria, Review Manager version 5.3 was used to perform a meta-analysis. Results: Meta-analysis of 27 RCTs, including 2554 subjects, revealed that the majority of the RCTs exhibited risk for ambiguous bias. The findings demonstrated that the use of Chinese medicine as an adjuvant treatment for CSVD effectively enhanced the cognitive function, as evidenced by improvements in the MMSE score (mean difference (MD) = 2.42, 95% confidence interval (CI) [1.79,3.17], P < .00001), MoCA score (MD = 2.39, 95% CI [1.78,2.99], P < .00001) and ADL score (MD = 4.13, 95% CI [1.74,6.51], P = .0007). Furthermore, the study also demonstrated the advantages of Chinese medicine adjuvant therapy in enhancing the Chinese medicine syndrome score (MD = −2.57, 95% CI [−3.31, −1.83], P < .00001), CRP (MD = −1.35, 95% CI [−2.27, −0.43], P = .004), Hcy (MD = −3.44,95% CI [−4.05, −2.83], P < .00001), and blood flow velocity (CBV) (MD = 1.37,95% CI [0.24,2.50], P = .02). Moreover, there was no statistical difference in the incidence of adverse reactions between the 2 groups. Conclusion: Findings of the present study indicate that the Chinese medicine, as an adjuvant to conventional treatment, appeared to be efficacious in enhancing cognitive function, reducing Chinese medicine syndrome score, improving blood biochemical markers, and improving cerebral blood flow perfusion in patients with CSVD, without any notable adverse reactions. However, it is imperative to validate these conclusions in future high-quality investigations.

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Comparative study on optimization of NADES extraction process by dual models and antioxidant activity of optimum extraction from Chuanxiong-Honghua

Zhou

et al. 2023

LWT

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A Review of Traditional Chinese Medicine, Buyang Huanwu Decoction for the Treatment of Cerebral Small Vessel Disease

Cited by 5 publications

References 107 publications

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

Evidence-based evaluation of adjuvant therapy with Chinese medicine for cerebral small vessel disease: A systematic review and meta-analysis

Comparative study on optimization of NADES extraction process by dual models and antioxidant activity of optimum extraction from Chuanxiong-Honghua

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