Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia

Luo, Yumin; Qin, Zhen; Hong, Zhen; Zhang, Xinmin; Ding, Ding; Fu, Jing; Zhang, Guoqing; Chen, Jun

doi:10.1016/j.neulet.2004.03.036

Cited by 192 publications

(138 citation statements)

References 17 publications

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“…In China, astragalus membranaceus was utilized for patients with chronic diseases and healthy individuals who wish to further improve vital functions (6). AS-IV, the primary pure saponin which is isolated from the root of astragalus membranaceus, was an effective compound with distinct pharmacological effects, including protecting against ischemic brain injury (6), lung inflammation (7), acute pancreatitis (8) and cardiac trauma (9).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of astragaloside IV on Parkinson disease models of mice and primary astrocytes

2017

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Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of astragaloside IV on Parkinson disease models of mice and primary astrocytes

2017

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“…The active herbal compounds may be flavonoids, saponins and lipids, and are extensively present in plants, fruits and vegetables (16,17). In fact, some herbal medicines may be potential therapeutics for oxidative disorders.…”

Section: Introductionmentioning

confidence: 99%

Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress

Cheung¹,

Lau²,

Shen³

et al. 2008

Int J Mol Med

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Abstract. Traditional medicines are clinically used to treat post-stroke disorders in China. In search of alternative medicines for post-stroke rehabilitation, we recently identified the heme oxygenase-1 (HO-1) pathway as a key mechanism underlying the biological activities of the ischemic stroke formulation ISF-1. This study was designed to further investigate ISF-1 for HO-1 induction in cultured human cells and corresponding cytoprotective effects against oxidative injury. A rat stroke model induced by middle cerebral artery occlusion was employed to verify the activity of ISF-1 in vivo. It was found that HO-1 expression was induced by ISF-1 in a dose-and time-dependent manner. Four ingredients from ISF-1 were identified to be responsible for HO-1 induction. The appropriate combinations of these active ingredients or purified compounds resulted in synergistic induction of HO-1 expression. A minimal HO-1-inducing formulation was prepared and showed significant cytoprotection against H 2 O 2 -induced oxidative stress. Collectively, the herbal formulation ISF-1 was capable of inducing HO-1 expression, in vitro and in vivo, offering a potential mechanism for post-stroke rehabilitation. This study may shed light on the development of mechanism-defined therapies based on traditional herbal remedies.

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“…Astragaloside IV [27], formononetin [28], ferulic acid [29] and ligustilide [30] are the main bioactive ingredients in the combined prescription of Danggui Buxue, and the former two compounds only exist in Radix Astragli and the latter two compounds in Radix Angelica Sinensis, respectively. The quantity of them is often taken as the norm for quality control of Danggui Buxue decoction and its compositions [31][32][33][34][35].…”

Section: Identification Of Astragaloside IV Formononetin Ferulic Acmentioning

confidence: 99%

Separation of compounds interacting with liposome membrane in combined prescription of traditional Chinese medicines with immobilized liposome chromatography

Sheng

Kong

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia

Cited by 192 publications

References 17 publications

Neuroprotective effects of astragaloside IV on Parkinson disease models of mice and primary astrocytes

Neuroprotective effects of astragaloside IV on Parkinson disease models of mice and primary astrocytes

Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress

Separation of compounds interacting with liposome membrane in combined prescription of traditional Chinese medicines with immobilized liposome chromatography

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