Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects

Zhang, Jianqin; Wu, Chu-Xuan; Gao, Li; Du, Guanhua; Qin, Xuemei

doi:10.1016/bs.apha.2019.08.002

Cited by 252 publications

(189 citation statements)

References 71 publications

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“…As the main active substance of Hedysarum multijugum Maxim ., astragaloside IV has a variety of pharmacological effects, including anti-inflammatory, antifibrosis, antioxidative stress, antiasthma, antidiabetic, and immune regulation [ 47 ]. The signaling pathways involved include the EGFR-Nrf2 signaling pathway, NF- κ B signaling pathway, signaling pathway Nrf2 antioxidant signaling pathway, PI3K/Akt/mTOR signaling pathway, and many other signaling pathways [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…Oxidative Medicine and Cellular Longevity EGFR-Nrf2 signaling pathway, NF-κB signaling pathway, signaling pathway Nrf2 antioxidant signaling pathway, PI3K/Akt/mTOR signaling pathway, and many other signaling pathways [48]. Meanwhile, the further research (GO and pathway enrichment analysis) showed that the mechanism of MBHD to treat VD is mainly related to neuronal apoptosis, nitric oxide synthesis and metabolism, platelet activation, NF-κB signaling pathway-mediated inflammation, oxidative stress, angiogenesis, etc.…”

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confidence: 99%

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Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy

Yang

Zeng

et al. 2021

Oxidative Medicine and Cellular Longevity

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Objective. To explore the oxidative stress mechanism of modified Buyang Huanwu decoction (MBHD) in intervention of vascular dementia (VD) based on systems biology strategy. Methods. In this study, through the reverse virtual target prediction technology and transcriptomics integration strategy, the active ingredients and potential targets of MBHD treatment of VD were analyzed, and the drug-disease protein-protein interaction (PPI) network was constructed. Then, bioinformatics analysis methods are used for Gene Ontology (GO) enrichment analysis and pathway enrichment analysis, and finally find the core biological process. After that, in animal models, low-throughput technology is used to detect gene expression and protein expression of key molecular targets in oxidative stress-mediated inflammation and apoptosis signaling pathways to verify the mechanism of MBHD treatment of VD rats. Finally, the potential interaction relationship between MBHD and VD-related molecules is further explored through molecular docking technology. Results. There are a total of 54 MBHD components, 252 potential targets, and 360 VD genes. The results of GO enrichment analysis and pathway enrichment analysis showed that MBHD may regulate neuronal apoptosis, nitric oxide synthesis and metabolism, platelet activation, NF-κB signaling pathway-mediated inflammation, oxidative stress, angiogenesis, etc. Among them, SIRT1, NF-κB, BAX, BCL-2, CASP3, and APP may be important targets for MBHD to treat VD. Low-throughput technology (qRT-PCR/WB/immunohistochemical technology) detects oxidative stress-mediated inflammation and apoptosis-related signaling pathway molecules. The molecular docking results showed that 64474-51-7, cycloartenol, ferulic acid, formononetin, kaempferol, liquiritigenin, senkyunone, wallichilide, xanthinin, and other molecules can directly interact with NF-κB p65, BAX, BCL-2, and CASP3. Conclusion. The active compounds of MBHD interact with multiple targets and multiple pathways in a synergistic manner, and have important therapeutic effects on VD mainly by balancing oxidative stress/anti-inflammatory and antiapoptotic, enhancing metabolism, and enhancing the immune system.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy

Yang

Zeng

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…AP could inhibit mitochondrial-mediated apoptosis and reduce cell damage by mediating the PI3K/Akt/FoxO3a signaling pathway ( Lu and Yang, 2017 ); it could also decrease hepatocytes apoptosis caused by oxidative stress ( Liu, 2018b ). AS-IV dose-dependently inhibited the rise in apoptosis induced by oxidative stress in renal podocytes ( Xiao et al., 2013 ), and prevented human umbilical vein endothelial cell (HUVEC) apoptosis by inhibiting Nox4 expression through the Nox4/Smad2 pathway (H 2 O 2 -induced cell apoptosis) ( Ma et al., 2015 ; Zhang et al., 2020b ). Baicalein protected cardiomyocytes by decreasing oxidative stress, myocardial inflammatory responses and apoptosis associated with LPS-induced sepsis ( Lee et al., 2011 ).…”

Section: Mechanisms Of Tcm Function In Treating Covid-19mentioning

confidence: 99%

Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism

Zhang

et al. 2021

Phytomedicine

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Background Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), have won much praise of the world. Purpose This review aimed to summarize and discuss the essential role of TCM in protecting tissues from injuries associated with COVID-19, and accordingly to clarify the possible action mechanisms of TCM from the perspectives of anti-inflammatory, antioxidant and anti-apoptotic effects. Methods Electronic databases such as Pubmed, ResearchGate, Science Direct, Web of Science, medRixv and Wiley were used to search scientific literatures. Results The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhizaSalvia miltiorrhiza , and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis. Conclusion TCM could protect COVID-19 patients from tissue injuries, a protection that might be, at least partially, attributed to the anti-inflammatory, antioxidant and anti-apoptotic effects of the TCM under investigation. This review provides evidence and support for clinical treatment and novel drug research using TCM.

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“…Then we deleted the active ingredients without matched targets and selected the active ingredients from 6 herbs according to oral bioavailability (OB) and drug likeness (DL) values (OB≥30% and DL≥0.18). Eventually, 67 active ingredients such as quercetin, isorhamnetin, luteolin and kaempferol were discovered (Table.1), and they all have hepatoprotective, anti-in ammatory, antibacterial, analgesic and antitumor effects [26][27][28][29] . To further uncover the potential pharmacological mechanisms of Piwei-Peiyuan Decoction against GC, pathway analysis was conducted to explore the potential pathways affected by Peiwei-Peiyuan Decoction.…”

Section: Ingredients and Targets Analysismentioning

confidence: 99%

Network Pharmacology-Based Approach to Investigate the Mechanisms of Piwei-Peiyuan Decoction in the Treatment of Gastric Carcinoma

Pei¹,

Wen²,

Zheng³

et al. 2021

Preprint

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Purpose Piwei-Peiyuan Decoction is a traditional Chinese medicine decoction, which has shown promising treatment in gastric carcinoma. However, the molecular mechanisms of gastric carcinoma (GC) have not been systematically revealed yet. In this work, a network pharmacology research was conducted to analyze mechanisms of Piwei-Peiyuan Decoction, aiming to provide a basis for the development and application of new drugs in treatment of GC. Methods In this study, a network pharmacology approach was used to predict targets, construct network maps and analyze relevant signaling pathways. We discovered active chemical ingredients and their targets in the Piwei-Peiyuan Decoction by the TCMSP and ADME database. Then we found main targets of GC by GeneCards (https://www.genecards.org), OMIM (http://www.omim.org) and DRUGBANK (https://go.drugbank.com) databases. According to the information of ingredients and GC, a PPI network was performed by the String (https://string-db.org) database. And a targets-pathways interaction network was constructed by Cytoscape (version 3.7.2), a bioinformatics software used for data visualization and integration. Results Our result indicated that the main active ingredients of Piwei-Peiyuan Decoction in treating GC are Isorhamnetin, Kaempferol, Quercetin and Luteolin, and main active targets are CASP-3, MAPK1, MYC, AKT1, P53. We found the mechanism of Piwei-Peiyuan Decoction for treating GC is mainly to regulate PI3K-Akt signaling pathway, MAPK signaling pathway, Ras signaling pathway, IL-17 signaling pathway, HIF-1α signaling pathway to inhibit cell proliferation, promote apoptosis and then exert anti-cancer effects. Conclusion This study preliminarily analyzed the multi-component, multi-target and multi-path mechanism of Peiwei-Peiyuan Decoction in the treatment of gastric carcinoma, providing a theoretical basis for its clinical application.

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Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects

Cited by 252 publications

References 71 publications

Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy

Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy

Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism

Network Pharmacology-Based Approach to Investigate the Mechanisms of Piwei-Peiyuan Decoction in the Treatment of Gastric Carcinoma

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