Asthmatics With Gastroesophageal Reflux: Long Term Results of A Randomized Trial of Medical and Surgical Antireflux Therapies

Sontag, Stephen J.; O’Çonnell, Susan; Khandelwal, Sharad; Greenlee, H.; Schnell, Thomas; Nemchausky, Bernard A.; Chejfec, Gregorio; Miller, Todd Q.; Seidel, John; Sonnenberg, Amnon

doi:10.1111/j.1572-0241.2003.07503.x

Cited by 73 publications

(45 citation statements)

References 21 publications

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“…Asthmatic patients have been found to have a much greater risk of GERD-related symptoms than the general population [78]. Patients with GERD have a significantly higher risk of concurrent asthma compared with patients without GERD [79].…”

Section: Gastroesophageal Reflux Diseasementioning

confidence: 99%

Asthma-related comorbidities

Boulet¹,

Boulay²

2011

Expert Review of Respiratory Medicine

220

147

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Section: Gastroesophageal Reflux Diseasementioning

confidence: 99%

Asthma-related comorbidities

Boulet¹,

Boulay²

2011

Expert Review of Respiratory Medicine

220

147

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“…Endoscopic examination interpretation based on the established LA classification was used in a randomized trial of medical therapy and surgical anti-reflux therapies to study the long-term asthma outcome (Sontag et al 2003). Although the established LA classification is based on the extent of the apparent erosive mucosal breaks of grades A to D, it does not include grade M, which denotes the non-erosive minimal mucosal change (Kiesslich et al 2004;Nakamura et al 2005) of the "discoloring" type of reflux esophagitis (Hoshihara and Hashimoto 2000;Shimoyama et al 2005).…”

mentioning

confidence: 99%

High Prevalence of Gastroesophageal Reflux Disease with Minimal Mucosal Change in Asthmatic Patients

Shimizu

Dobashi

Kobayashi³

et al. 2006

Tohoku J. Exp. Med.

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It is known that the prevalence of gastroesophageal reflux disease (GERD) in asthmatic patients is high. Although an endoscopic diagnosis of GERD based on the established Los Angeles (LA) classification requires the detection of erosive mucosal breaks, there are patients with GERD who have prominent erythema of the esophageal membrane without erosive mucosal breaks. Non-erosive mucosal change denotes the minimal change of the discoloring type of reflux esophagitis. This study was undertaken to determine the prevalence of GERD in asthmatic patients using the LA classification with the inclusion of minimal change, compared to the prevalence determined using the established LA classification without minimal change. The presence of GERD in asthmatic patients (n = 78), non-asthmatic disease control patients (n = 56), and healthy subjects (n = 150) was evaluated by endoscopic examination. The frequency of GERD in asthmatic patients based on the LA classification with minimal change was higher (54/78, 69.2%) than in asthmatic patients based on the LA classification without minimal change (37/78, 47.4%) ( p < 0.05). The prevalence of GERD in asthmatic patients (69.2%) was higher than that in disease control patients (17/56, 30.4%) and healthy subjects (27/150, 18.0%) based on the LA classification with minimum change. These data indicate that asthmatic patients have a high frequency of GERD. In addition, without the inclusion of minimum change to the diagnosis of GERD, the prevalence of GERD appears to be underestimated in asthmatic patients. Therefore, physicians should carefully observe asthmatic patients with minimal change on endoscopy.

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“…The p-values for significant predictors are shown, ns indicates non-significance. The subscale Bronchitis is a calculated mean from items numbers 8,9,12,13,14,15 and 16 in the RASQ.…”

Section: Discussionmentioning

confidence: 99%

Airway symptoms and sleeping difficulties in operated and non-operated patients with gastroesophageal reflux disease

Johannessen

Petersen

Olberg

et al. 2012

Scandinavian Journal of Gastroenterology

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Asthmatics With Gastroesophageal Reflux: Long Term Results of A Randomized Trial of Medical and Surgical Antireflux Therapies

Abstract: In patients with both GER and asthma, antireflux surgery (but not medical therapy with ranitidine 150 mg t.i.d.) has minimal effect on pulmonary function, pulmonary medication requirements, or survival, but significantly improves asthma symptoms and overall clinical status.

Cited by 73 publications

References 21 publications

Asthma-related comorbidities

Asthma-related comorbidities

High Prevalence of Gastroesophageal Reflux Disease with Minimal Mucosal Change in Asthmatic Patients

Airway symptoms and sleeping difficulties in operated and non-operated patients with gastroesophageal reflux disease

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