Asthma Worsened by Benzoate Contained in Some Antiasthmatic Drugs

Balatsinou, Loukia; Gioacchino, G. Di; Sabatino, Giuseppe; Cavallucci, E.; Caruso, Raffaele; Gabriele, Elisabetta; Ramondo, S.; Giampaolo, Luca Di; Verna, N; Gioacchino, M. Di

doi:10.1177/039463200401700215

Cited by 12 publications

(14 citation statements)

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“…Mast cells are essential not only for allergies [10,11] but also for innate and acquired immunity, autoimmunity and inflammation [12][13][14][15][16]. They mediate all these processes through the release of various mediators: histamine, proteases (tryptase, chymase), proteoglycans and prostaglandin D2.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

et al. 2006

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Mast cells are involved in inflammatory processes and in allergic reactions where immunologic stimulation leads to degranulation and generation of numerous cytokines and inflammatory mediators. Mast cells have been proposed as an immune gate to the brain, as well as sensors of environmental and emotional stress, and are likely involved in neuropathologic processes such as multiple sclerosis. Among mast cell products, the protease tryptase could be associated with neurodegenerative processes through the activation of specific receptors (PARs) expressed in the brain, while interleukin (IL)-6 likely causes neurodegeneration and exacerbates dysfunction induced by other cytokines; or it could have a protective effect against demyelinisation. In this report we show that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from human mast cell (HMC)-1 cells. As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation.

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

et al. 2006

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“…The small size of our sample does not allow for definitive conclusions about the clinical features of the infants described by this scale of validation, even considering that some neurological impairments of language and concentration are detectable only after the 2nd year of corrected age (27). Though our study confirms that in FEA preterms the occurrence of DEHSI is quite frequent, an MR finding with overt features of a WM injury should be considered as a negative prognostic factor for the psychoneurobehavioural development (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) of the infant affected. Our observations, together with further follow-up studies, which reach school age, could confirm that DEHSI has clinical significance and cannot be considered simply an indicator of delayed WM maturation.…”

Section: Discussionmentioning

confidence: 60%

Excessively High Magnetic Resonance Signal in Preterm Infants and Neuropsychobehavioural Follow-up at 2 Years

Domizio

Barbante

Puglielli

et al. 2005

Int J Immunopathol Pharmacol

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The diffuse excessive high-signal intensity (DEHSI) findings in the T2 weighted scans of white matter (WM), besides the corresponding low signal in the T1 weighted images, are usually more evident around the periventricular regions. It is not clear whether the DEHSI should be considered as a diffuse WM injury rather than a sign of delayed maturation of the WM. Eighty nine preterm infants at the full-term equivalent age (FEA) were studied using conventional Magnetic Resonance (MR) imaging of the brain. Based on the MR findings, the infants studied were divided into three groups: the control group presenting normal WM, the DEHSI group and the group with other WM lesions. Ten newborns were not included in the statistical analysis because they presented evidence of precedent germinal matrix hemorrhage (GMH-IVH) which cannot be considered as WM lesions. Seventy nine infants were enrolled in a program of neuropsychobehavioural study follow-up until 24 months of age. Each infant was evaluated for those variables which mostly affect the occurrence of neuropsychomotor disability. In the DEHSI infant group, significantly lower mean pH and mean base excess (BE) values were found in comparison to controls, while the mean birth weight (BW) was significantly higher. No significant difference was observed between the mean 1st minute Apgar Score, mean birth gestational age (GA) and assisted ventilation mean duration of controls and DEHSI groups. Finally, no significant difference between the parameters studied was found by comparing the WM lesion infants group to the DEHSI infants one. Our observations, together with follow-up studies, even up to school age, confirm that DEHSI has a clinical significance and cannot be considered as a simple indicator of delayed WM maturation.

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“…A reduction in sphingolipid synthesis was associated with increased airway hyperractivity in children [40], which is congruent with the estimated sign of the sR AW effect on the intensity of the two sphingolipid metabolites. Benzoate preservatives have been linked to lung function-related phenotypes [1,43], and pyruvate and lactate (q-value = 0.23) levels have previously been associated with asthma [54,41].…”

Section: Simulation Resultsmentioning

confidence: 99%

“…Then the P values defined in Step (1) of Algorithm 4.1 are p g,k = 2Φ − z g,k 1/2 , where Φ is the probit function. We first note that n −1 ñ = P r g1 = 1 + o a.s. (1) where P r g1 = 1 > 0 by Lemma S6.1 and…”

Section: Assume the Following Holdmentioning

confidence: 93%

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Estimation and inference in metabolomics with non-random missing data and latent factors

McKennan

Ober

Nicolae

2019

Preprint

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High throughput metabolomics data are fraught with both non-ignorable missing observations and unobserved factors that influence a metabolite's measured concentration, and it is well known that ignoring either of these complications can compromise estimators. However, current methods to analyze these data can only account for the missing data or unobserved factors, but not both. We therefore developed MetabMiss, a statistically rigorous method to account for both non-random missing data and latent factors in high throughput metabolomics data. Our methodology does not require the practitioner specify a probability model for the missing data, and makes investigating the relationship between the metabolome and tens, or even hundreds, of phenotypes computationally tractable. We demonstrate the fidelity of MetabMiss's estimates using both simulated and real metabolomics data.

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Asthma Worsened by Benzoate Contained in Some Antiasthmatic Drugs

Cited by 12 publications

References 4 publications

Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

Excessively High Magnetic Resonance Signal in Preterm Infants and Neuropsychobehavioural Follow-up at 2 Years

Estimation and inference in metabolomics with non-random missing data and latent factors

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